2017
Mycosis Fungoides and Sezary Syndrome
Foss FM, Girardi M. Mycosis Fungoides and Sezary Syndrome. Hematology/Oncology Clinics Of North America 2017, 31: 297-315. PMID: 28340880, DOI: 10.1016/j.hoc.2016.11.008.Peer-Reviewed Original ResearchConceptsSkin-directed therapiesSezary syndromeLymph nodesMycosis fungoidesAllogeneic stem cell transplantationSystemic immunomodulatory agentsVisceral organ involvementSingle-agent chemotherapyStem cell transplantationPatch/plaqueHelper T cellsExtent of skinDiffuse erythrodermaBlood involvementOrgan involvementRefractory diseaseVisceral involvementResistant diseaseRare lymphomaCell transplantationImmunomodulatory agentsPlaque diseaseCurative strategiesT cellsDisease
2014
A Phase II trial of Belinostat (PXD101) in patients with relapsed or refractory peripheral or cutaneous T‐cell lymphoma
Foss F, Advani R, Duvic M, Hymes KB, Intragumtornchai T, Lekhakula A, Shpilberg O, Lerner A, Belt RJ, Jacobsen ED, Laurent G, Ben‐Yehuda D, Beylot‐Barry M, Hillen U, Knoblauch P, Bhat G, Chawla S, Allen LF, Pohlman B. A Phase II trial of Belinostat (PXD101) in patients with relapsed or refractory peripheral or cutaneous T‐cell lymphoma. British Journal Of Haematology 2014, 168: 811-819. PMID: 25404094, DOI: 10.1111/bjh.13222.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic AgentsDrug Administration ScheduleFemaleHistone Deacetylase InhibitorsHumansHydroxamic AcidsInfusions, IntravenousLymphoma, T-Cell, CutaneousLymphoma, T-Cell, PeripheralMaleMiddle AgedNeoplasm StagingRecurrenceSulfonamidesTreatment OutcomeYoung AdultConceptsCutaneous T-cell lymphomaPeripheral T-cell lymphomaObjective response rateT-cell lymphomaPrior systemic therapyStage IV diseaseSystemic therapyAdverse eventsTreatment-related serious adverse eventsRefractory peripheral T-cell lymphomaTreatment-related adverse eventsPan-histone deacetylase inhibitorInfusion site painSkin-directed therapiesGrade 4 thrombocytopeniaSerious adverse eventsPhase II trialJugular vein thrombosisAnti-angiogenic propertiesOpen labelII trialParalytic ileusPeripheral edemaPrimary endpointSite pain
2007
Efficacy and tolerability of currently available therapies for the mycosis fungoides and Sezary syndrome variants of cutaneous T-cell lymphoma
Whittaker SJ, Foss FM. Efficacy and tolerability of currently available therapies for the mycosis fungoides and Sezary syndrome variants of cutaneous T-cell lymphoma. Cancer Treatment Reviews 2007, 33: 146-160. PMID: 17275192, DOI: 10.1016/j.ctrv.2006.08.006.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaT-cell lymphomaMycosis fungoidesTherapeutic optionsPrimary cutaneous T-cell lymphomaSkin-directed therapiesAggressive clinical courseCurrent therapeutic optionsNon-Hodgkin lymphomaNovel therapeutic targetCritical unmet needWorld Health OrganizationCharacteristic clinicopathologicImmunologic changesCutaneous lymphomasDurable responsesSystemic therapyClinical courseDefinitive treatmentSezary syndromeImmunophenotypic featuresTreatment of cancerAvailable therapiesCell transplantationDisease progression
2006
Clinical Experience: Practical Management of Five Patients With Cutaneous T-Cell Lymphoma (CTCL)-Related Symptoms
Dummer R, Foss F, Dreno B, Bagot M. Clinical Experience: Practical Management of Five Patients With Cutaneous T-Cell Lymphoma (CTCL)-Related Symptoms. Seminars In Oncology 2006, 33: 26-32. PMID: 16516673, DOI: 10.1053/j.seminoncol.2005.12.020.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaSkin-directed therapiesEarly-stage diseasePatient-specific factorsT-cell lymphomaReferral centerStage diseaseSystemic therapyTopical chemotherapyTreatment algorithmTherapeutic optionsIndividual patientsLymphoma managementPatientsSpecialized therapiesTherapyBeam radiationChemotherapySymptomsPractical managementUVA irradiationSpecific factorsPhotopheresisLymphomaCarmustine