2015
Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential
Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC. Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential. Cell 2015, 160: 269-284. PMID: 25594183, PMCID: PMC4436082, DOI: 10.1016/j.cell.2014.11.042.Peer-Reviewed Original ResearchConceptsBone morphogenetic proteinStem cellsMarrow stromal cellsMesenchymal stem cellsGremlin-1Skeletal stem cellsTissue stem cellsFate-mapping experimentsStromal cellsMorphogenetic proteinsPostnatal skeletonBone developmentCell of originMesenchymal sheathCellsAdipocytesOsteoblastsExpressionBone marrowChondrocytesProteinBone remodelingPerisinusoidal spaceRemodelingFracture repair
2002
Repair of Bone Allograft Fracture Using Bone Morphogenetic Protein-2
Lee FY, Storer S, Hazan EJ, Gebhardt MC, Mankin HJ. Repair of Bone Allograft Fracture Using Bone Morphogenetic Protein-2. Clinical Orthopaedics And Related Research® 2002, 397: 119-126. PMID: 11953604, DOI: 10.1097/00003086-200204000-00017.Peer-Reviewed Original ResearchConceptsAllograft fractureNormal fracture healingFracture healingProtein 2Long-term clinical dataExtensive tumour surgeryBone morphogenetic protein-2Major revision surgeryMorphogenetic protein-2Experimental groupOnly fibrosisRadiographic unionNew bone formationRevision surgeryAdditional ratsClinical dataTumor surgeryBone allograftAllograft boneControl groupBiologic regulatorsOsteotomy siteFracture repairRecombinant human bone morphogenetic protein-2Adequate function
2000
Experimental model for allograft incorporation and allograft fracture repair
Lee F, Hazan E, Gebhardt M, Mankin H. Experimental model for allograft incorporation and allograft fracture repair. Journal Of Orthopaedic Research® 2000, 18: 303-306. PMID: 10815832, DOI: 10.1002/jor.1100180219.Peer-Reviewed Original ResearchConceptsAllograft incorporationFracture repairHost-donor interfaceSprague-Dawley ratsSkeletal defectsAdult LewisImmediate ambulationIntercalary allograftsRat modelHistological examinationOsteotomy healingKirschner wiresMuscle layerOsteotomy siteTransverse osteotomyExperimental modelHealing processAllograftsRepair processRepairAmbulation