2009
Targeting extracellular signal-regulated kinase (ERK) signaling has therapeutic implications for inflammatory osteolysis
Seo SW, Lee D, Minematsu H, Kim AD, Shin M, Cho SK, Kim DW, Yang J, Lee FY. Targeting extracellular signal-regulated kinase (ERK) signaling has therapeutic implications for inflammatory osteolysis. Bone 2009, 46: 695-702. PMID: 19895919, PMCID: PMC2823832, DOI: 10.1016/j.bone.2009.10.032.Peer-Reviewed Original ResearchConceptsInflammatory osteolysisInflammatory responseInnate immune responseExtracellular signal-regulated kinase (ERK) signalingImportant therapeutic targetM-CSF expressionSignal-regulated kinase 1/2 pathwaySignal-regulated kinase signalingExtracellular signal-regulated kinase 1/2 (ERK1/2) pathwayInhibition of ERKImmune responseTherapeutic implicationsTherapeutic targetOsteoclast precursorsKinase 1/2 pathwayM-CSFOsteolysisERK pathwayMacrophage colonyLPSERKERK signalsMitogen-activated protein kinase (MAPK) familyKinase signalingCell differentiation
2007
ERK Signaling Regulates Macrophage Colony‐Stimulating Factor Expression Induced by Titanium Particles in MC3T3.E1 Murine Calvarial Preosteoblastic Cells
SEO SW, LEE D, CHO SK, KIM AD, MINEMATSU H, AYDEMIR A, GELLER JA, MACAULAY W, YANG J, LEE F. ERK Signaling Regulates Macrophage Colony‐Stimulating Factor Expression Induced by Titanium Particles in MC3T3.E1 Murine Calvarial Preosteoblastic Cells. Annals Of The New York Academy Of Sciences 2007, 1117: 151-158. PMID: 18056041, DOI: 10.1196/annals.1402.027.Peer-Reviewed Original ResearchConceptsM-CSF expressionExtracellular signal-regulated kinase (ERK) pathwaySignal-regulated kinase pathwayPreosteoblastic cellsSignal transduction pathwaysSpecific ERK inhibitorReverse transcriptase-polymerase chain reactionEnzyme-linked immunosorbent assayPreosteoclast proliferationTransduction pathwaysKinase pathwayMolecular mechanismsMacrophage colony-stimulating factorCellular environmentERK inhibitorPeriprosthetic osteolysisM-CSF productionNuclear factor kappa beta ligandCell populationsBeta ligandSignificant clinical problemTranscriptase-polymerase chain reactionExpressionDose-dependent mannerColony-stimulating factor