Featured Publications
Locally delivered adjuvant biofilm‐penetrating antibiotics rescue impaired endochondral fracture healing caused by MRSA infection
Cahill SV, Kwon H, Back J, Lee I, Lee S, Alder KD, Hao Z, Yu KE, Dussik CM, Kyriakides T, Lee F. Locally delivered adjuvant biofilm‐penetrating antibiotics rescue impaired endochondral fracture healing caused by MRSA infection. Journal Of Orthopaedic Research® 2021, 39: 402-414. PMID: 33336805, DOI: 10.1002/jor.24965.Peer-Reviewed Original ResearchConceptsHigh-dose rifampinFracture healingMRSA infectionMethicillin-resistant Staphylococcus aureus osteomyelitisColony-forming unitsTissue bacterial loadStaphylococcus aureus osteomyelitisReactive bone formationRadiographic union scaleEndochondral fracture healingBacterial CFU countsPoor callus formationSoft callus formationTibia scoresRifampin therapyDevastating complicationMRSA colonizationClinical efficacyInfected fracturesTibial radiographsTreatment responseMurine modelIntramedullary pinOpen fracturesO stain
2020
Recalcitrant methicillin-resistant Staphylococcus aureus infection of bone cells: Intracellular penetration and control strategies
Yu K, Song L, Kang HP, Kwon HK, Back J, Lee FY. Recalcitrant methicillin-resistant Staphylococcus aureus infection of bone cells: Intracellular penetration and control strategies. Bone And Joint Research 2020, 9: 49-59. PMID: 32435455, PMCID: PMC7229311, DOI: 10.1302/2046-3758.92.bjr-2019-0131.r1.Peer-Reviewed Original ResearchMethicillin-resistant Staphylococcus aureus (MRSA) infectionsEarly antibiotic administrationHours of injuryStandard of careStaphylococcus aureus infectionBone resident cellsEffect of cefazolinBone Joint ResAntibiotic regimensAntibiotic administrationCombined administrationAntibiotic treatmentAureus infectionProtective effectSurgical preparationMRSA growthOpen fracturesPreparation agentsDetergent susceptibilityPrimary murine osteoblastsBacterial bioburdenMRSAColony formationRifampicinBone cells