2006
Mechanical Loading Differentially Regulates Membrane‐Bound and Soluble RANKL Availability in MC3T3‐E1 Cells
KIM DW, LEE H, KARMIN JA, LEE E, CHANG S, TOLCHIN B, LIN S, CHO SK, KWON A, AHN JM, LEE F. Mechanical Loading Differentially Regulates Membrane‐Bound and Soluble RANKL Availability in MC3T3‐E1 Cells. Annals Of The New York Academy Of Sciences 2006, 1068: 568-572. PMID: 16831954, DOI: 10.1196/annals.1346.054.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAnimalsBiomechanical PhenomenaCarrier ProteinsDNA, ComplementaryMembrane GlycoproteinsMiceOsteoblastsPhysical Conditioning, AnimalRANK LigandReceptor Activator of Nuclear Factor-kappa BWeight-Bearing
2005
Zoledronate induces apoptosis in cells from fibro‐cellular membrane of unicameral bone cyst (UBC)
Yu J, Chang S, Suratwala S, Chung W, Abdelmessieh P, Lee H, Yang J, Lee F. Zoledronate induces apoptosis in cells from fibro‐cellular membrane of unicameral bone cyst (UBC). Journal Of Orthopaedic Research® 2005, 23: 1004-1012. PMID: 15921873, DOI: 10.1016/j.orthres.2005.02.012.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisBone CystsCarrier ProteinsCell MembraneChemokine CXCL12Chemokines, CXCDiphosphonatesFlow CytometryHumansImidazolesImmunoblottingMembrane GlycoproteinsOsteoclastsRANK LigandReceptor Activator of Nuclear Factor-kappa BStromal CellsZoledronic AcidConceptsUnicameral bone cystsPeripheral blood mononuclear cellsBlood mononuclear cellsTrabecular bone cellsBone cystUBC cellsMononuclear cellsBone cellsZoledronate concentrationsIsolated peripheral blood mononuclear cellsImmunohisto/cytochemistryPercutaneous injection therapyAnti-resorptive agentsAnti-osteoclastogenic effectApoptotic fractionSTRO-1Potential therapeutic effectsPotential therapeutic roleEffect of zoledronateBenign cystic lesionsNitrogen-containing bisphosphonatesDose-dependent mannerOsteoclast-like cellsInjection therapyPathologic fractureμ-Calpain Regulates Receptor Activator of NF-κB Ligand (RANKL)-supported Osteoclastogenesis via NF-κB Activation in RAW 264.7 Cells*
Lee FY, Kim DW, Karmin JA, Hong D, Chang SS, Fujisawa M, Takayanagi H, Bigliani LU, Blaine TA, Lee HJ. μ-Calpain Regulates Receptor Activator of NF-κB Ligand (RANKL)-supported Osteoclastogenesis via NF-κB Activation in RAW 264.7 Cells*. Journal Of Biological Chemistry 2005, 280: 29929-29936. PMID: 15955824, DOI: 10.1074/jbc.m414600200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalpainCarrier ProteinsCell DifferentiationCell LineI-kappa B ProteinsMacrophagesMembrane GlycoproteinsMiceNF-kappa BNF-KappaB Inhibitor alphaOsteoclastsRANK LigandReceptor Activator of Nuclear Factor-kappa BConceptsRAW 264.7 cellsNF-kappaB activationReceptor activatorCalpain inhibitorsCell-permeable calpain inhibitorMatrix metalloproteinase-9Regulation of RANKLNF-κB activationNF-κB ligandNF-kappaB ligandMonocyte/macrophage progenitorsRole of calpainMurine RAW 264.7 cellsCell typesMetalloproteinase-9Osteoclastogenic markersCalpain activationResistant acidDecreased expressionOsteoclastogenesisRANKLCalpain activityMu-calpainInhibitorsActivation