2021
The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors?
Marx A, Chan JKC, Chalabreysse L, Dacic S, Detterbeck F, French CA, Hornick JL, Inagaki H, Jain D, Lazar AJ, Marino M, Marom EM, Moreira AL, Nicholson AG, Noguchi M, Nonaka D, Papotti MG, Porubsky S, Sholl LM, Tateyama H, Thomas de Montpréville V, Travis WD, Rajan A, Roden AC, Ströbel P. The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors? Journal Of Thoracic Oncology 2021, 17: 200-213. PMID: 34695605, DOI: 10.1016/j.jtho.2021.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaGerm CellsHumansLung NeoplasmsMediastinumThymus NeoplasmsWorld Health OrganizationConceptsThymic epithelial tumorsGerm cell tumorsCell tumorsMesenchymal neoplasmsWHO classificationEpithelial tumorsMediastinal germ cell tumorsLow tumor mutational burdenTumor mutational burdenNew tumor entityClear cell carcinomaPositron emission tomographyClassification of tumorsThymic EpithelialThymic carcinomaFifth editionB3 thymomaTargetable mutationsCell carcinomaMesenchymal tumorsMetaplastic thymomaImmunohistochemical characterizationClinical informationMutational burdenDiagnostic advances
2019
Distribution of Mediastinal Lesions Across Multi-Institutional, International, Radiology Databases
Roden AC, Fang W, Shen Y, Carter BW, White DB, Jenkins SM, Spears GM, Molina JR, Klang E, Segni M, Ackman JB, Sanchez EZ, Girard N, Shumeri E, Revel MP, Chassagnon G, Rubinowitz A, Dicks D, Detterbeck F, Ko JP, Falkson C, Sigurdson S, Segreto S, Del Vecchio S, Palmieri G, Ottaviano M, Marino M, Korst R, Marom EM. Distribution of Mediastinal Lesions Across Multi-Institutional, International, Radiology Databases. Journal Of Thoracic Oncology 2019, 15: 568-579. PMID: 31870881, DOI: 10.1016/j.jtho.2019.12.108.Peer-Reviewed Original ResearchConceptsMediastinal lesionsDistribution of lesionsBenign cystsMediastinal compartmentPositron emission tomography-computed tomographyEmission tomography-computed tomographyCommon mediastinal lesionsMulti-institutional cohortTomography-computed tomographyBenign mediastinal cystsParavertebral lesionsThymic carcinomaThymic hyperplasiaMediastinal massNeurogenic tumorsSurgical databaseMediastinal cystsRadiology databaseSingle institutionCommon lesionsMediastinal abnormalitiesDifferential diagnosisMediastinal noduleComputed tomographyDemographic data
2017
Indications for invasive mediastinal staging in patients with early non-small cell lung cancer staged with PET-CT
Gao SJ, Kim AW, Puchalski JT, Bramley K, Detterbeck FC, Boffa DJ, Decker RH. Indications for invasive mediastinal staging in patients with early non-small cell lung cancer staged with PET-CT. Lung Cancer 2017, 109: 36-41. PMID: 28577947, DOI: 10.1016/j.lungcan.2017.04.018.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungClinical Decision-MakingDiagnostic ImagingFemaleHumansLung NeoplasmsMaleMediastinumMiddle AgedNeoplasm MetastasisNeoplasm StagingPatient SelectionPositron Emission Tomography Computed TomographyPractice Guidelines as TopicRetrospective StudiesConceptsOccult N2 diseaseOccult N2 metastasesGround-glass componentInvasive mediastinal stagingCurative-intent therapyT2 tumorsN2 metastasisPET-CTInvasive stagingN2 diseaseT1 tumorsNegative predictive valueMediastinal stagingEarly non-small cell lung cancerExact testPredictive valueSolid tumorsNon-small cell lung cancerClinical stage I NSCLCN2 lymph nodesNode-negative NSCLCOccult nodal involvementPure-solid tumorsStage I NSCLCT1-2N0 disease
2014
Approaching the Patient with an Anterior Mediastinal Mass: A Guide for Clinicians
Carter BW, Marom EM, Detterbeck FC. Approaching the Patient with an Anterior Mediastinal Mass: A Guide for Clinicians. Journal Of Thoracic Oncology 2014, 9: s102-s109. PMID: 25396306, DOI: 10.1097/jto.0000000000000294.Peer-Reviewed Original ResearchA Modern Definition of Mediastinal Compartments
Carter BW, Tomiyama N, Bhora FY, de Christenson M, Nakajima J, Boiselle PM, Detterbeck FC, Marom EM. A Modern Definition of Mediastinal Compartments. Journal Of Thoracic Oncology 2014, 9: s97-s101. PMID: 25396318, DOI: 10.1097/jto.0000000000000292.Peer-Reviewed Original ResearchMeSH KeywordsConsensusDiagnosis, DifferentialHumansMediastinal NeoplasmsMediastinumTomography, X-Ray ComputedConceptsInternational Thymic Malignancy Interest GroupProspective clinical trialsLateral chest radiographsParavertebral compartmentMediastinal massClinical trialsDifferential diagnosisChest radiographsSurgical proceduresClinical classificationMediastinal compartmentClinical casesAnatomic boundariesArbitrary landmarksCompartmentsMediastinumBiopsyTranscervical Wedge Resection After Transcervical Extended Mediastinal Lymphadenectomy
Kim AW, Kull DR, Zieliski M, Boffa DJ, Detterbeck FC. Transcervical Wedge Resection After Transcervical Extended Mediastinal Lymphadenectomy. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2014, 9: 327-329. PMID: 25084246, DOI: 10.1097/imi.0000000000000079.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaFemaleHumansLung NeoplasmsLymph Node ExcisionMediastinumMiddle AgedNeckPneumonectomyConceptsSame anesthetic settingMediastinal lymphadenectomyWedge resectionM0 adenocarcinomaAnesthetic settingRight upper lobe wedge resectionTranscervical extended mediastinal lymphadenectomyAbsence of lymphPerioperative adverse eventsGround-glass opacitiesExtended mediastinal lymphadenectomyAtypical adenomatous hyperplasiaAdverse eventsLower lobectomyLung resectionCervical approachUpper lobeClinical stageGlass opacitiesLower lobeAdenomatous hyperplasiaPleural spaceResectionLymphadenectomyExcellent access
2012
The Fable of Babel and Building a Foundation for Quality
Detterbeck FC. The Fable of Babel and Building a Foundation for Quality. Journal Of Thoracic Oncology 2012, 7: 267-268. PMID: 22252560, DOI: 10.1097/jto.0b013e318243262a.Peer-Reviewed Original ResearchThoroughness of Mediastinal Staging in Stage IIIA Non-small Cell Lung Cancer
Vest MT, Tanoue L, Soulos PR, Kim AW, Detterbeck F, Morgensztern D, Gross CP. Thoroughness of Mediastinal Staging in Stage IIIA Non-small Cell Lung Cancer. Journal Of Thoracic Oncology 2012, 7: 188-195. PMID: 22134069, PMCID: PMC3253367, DOI: 10.1097/jto.0b013e318236ecbb.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiopsy, NeedleCarcinoma, Non-Small-Cell LungCohort StudiesComorbidityConfidence IntervalsGuideline AdherenceHumansLung NeoplasmsLymph NodesMediastinoscopyMediastinumMedicareMultivariate AnalysisNeoplasm StagingOdds RatioPositron-Emission TomographySEER ProgramSurvival AnalysisUnited StatesConceptsStage IIIA non-small cell lung cancerIIIA non-small cell lung cancerNon-small cell lung cancerInvasive stagingCell lung cancerMediastinal stagingLung cancerClinical stage IIIA non-small cell lung cancerEnd Results-Medicare databaseStage IIIA NSCLC patientsPositron emission tomography scanningPathologic lymph nodesIIIA NSCLC patientsMultivariable logistic regressionInvasive mediastinal stagingNSCLC patientsOlder patientsPatient characteristicsLymph nodesPatient factorsHistologic confirmationPractice patternsMedicare claimsMedicare beneficiariesPET scanning
2010
Classification of the Thoroughness of Mediastinal Staging of Lung Cancer
Detterbeck F, Puchalski J, Rubinowitz A, Cheng D. Classification of the Thoroughness of Mediastinal Staging of Lung Cancer. CHEST Journal 2010, 137: 436-442. PMID: 20133290, DOI: 10.1378/chest.09-1378.Books
2008
Management Algorithms for Stage IIIA Non–Small Cell Lung Cancer with N2 Node Involvement
Detterbeck F, Sukumar MS. Management Algorithms for Stage IIIA Non–Small Cell Lung Cancer with N2 Node Involvement. Thoracic Surgery Clinics 2008, 18: 437-441. PMID: 19086612, DOI: 10.1016/j.thorsurg.2008.08.006.Peer-Reviewed Original ResearchWhat to do with “Surprise” N2?: Intraoperative Management of Patients with Non-small Cell Lung Cancer
Detterbeck F. What to do with “Surprise” N2?: Intraoperative Management of Patients with Non-small Cell Lung Cancer. Journal Of Thoracic Oncology 2008, 3: 289-302. PMID: 18317073, DOI: 10.1097/jto.0b013e3181630ebd.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerMediastinal lymph node dissectionLymph node dissectionMediastinal lymph nodesPositive prognostic factorCell lung cancerAdjuvant therapyNode dissectionLung resectionLymph nodesMalignant involvementPrognostic factorsIntraoperative managementLung cancerPatientsConflicting dataResectionTherapyCancerDiseaseDissectionComprehensive review
2007
Integration of Mediastinal Staging Techniques for Lung Cancer
Detterbeck FC. Integration of Mediastinal Staging Techniques for Lung Cancer. Seminars In Thoracic And Cardiovascular Surgery 2007, 19: 217-224. PMID: 17983948, DOI: 10.1053/j.semtcvs.2007.07.011.Peer-Reviewed Original ResearchInvasive Mediastinal Staging of Lung Cancer ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition)
Detterbeck FC, Jantz MA, Wallace M, Vansteenkiste J, Silvestri GA. Invasive Mediastinal Staging of Lung Cancer ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition). CHEST Journal 2007, 132: 202s-220s. PMID: 17873169, DOI: 10.1378/chest.07-1362.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerLymph nodesInvasive stagingMediastinal nodesClinical stage I non-small cell lung cancerLung Cancer ACCP Evidence-Based Clinical Practice GuidelinesACCP Evidence-Based Clinical Practice GuidelinesStage I non-small cell lung cancerNeedle techniqueEvidence-based clinical practice guidelinesLeft upper lobe tumorsNormal-sized lymph nodesPositron emission tomography scanningPET scan findingsUpper lobe tumorsMediastinal lymph nodesCell lung cancerClinical practice guidelinesStaging of patientsInvasive mediastinal stagingHigher FN rateInvasive confirmationMediastinal infiltrationNode enlargementScan findings