Obesity-Linked PPARÎł S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3
Hall JA, Ramachandran D, Roh HC, DiSpirito JR, Belchior T, Zushin PH, Palmer C, Hong S, Mina AI, Liu B, Deng Z, Aryal P, Jacobs C, Tenen D, Brown CW, Charles JF, Shulman GI, Kahn BB, Tsai LTY, Rosen ED, Spiegelman BM, Banks AS. Obesity-Linked PPARÎł S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3. Cell Metabolism 2020, 32: 665-675.e6. PMID: 32941798, PMCID: PMC7543662, DOI: 10.1016/j.cmet.2020.08.016.Peer-Reviewed Original ResearchConceptsInsulin resistanceInsulin sensitivitySide effectsObesity-linked phosphorylationSignificant side effectsLigands of PPARÎłHyperinsulinemic-euglycemic clamp experimentsPromotes Insulin ResistanceDiabetogenic roleReceptor agonismGrowth differentiation factor 3Healthy miceBody weightMice revealsThiazolidinedionesClamp experimentsPPARÎłMiceInhibits BMPFamily membersFactor 3Putative targetsSerine 273Ectopic expressionBMP family members