miR-221/222 activate the Wnt/ÎČ-catenin signaling to promote triple-negative breast cancer
Liu S, Wang Z, Liu Z, Shi S, Zhang Z, Zhang J, Lin H. miR-221/222 activate the Wnt/ÎČ-catenin signaling to promote triple-negative breast cancer. Journal Of Molecular Cell Biology 2018, 10: 302-315. PMID: 30053090, DOI: 10.1093/jmcb/mjy041.Peer-Reviewed Original ResearchConceptsTriple-negative breast cancerWnt/ÎČ-cateninMiR-221/222 expressionTNBC cell linesBreast cancerMiR-221/222Î-cateninHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Progression of TNBCGrowth factor receptor 2Limited treatment optionsWnt/ÎČ-catenin activationNegative breast cancerFactor receptor 2Primary tumor samplesWnt/ÎČ-catenin signalingCell linesWnt3a treatmentMultiple negative regulatorsÎ-catenin activationÎ-catenin signalingPatient survivalPoor prognosisTreatment options