2024
Self-Assembled Fibroblast Growth Factor Nanoparticles as a Therapeutic for Oxidant-Induced Neuronal and Skin Cell Injury
Kumar S, Chu A, Theis T, Rastogi S, Costea D, Banerjee R, Das B, Yarmush M, Hsia H, Cohen R, Schachner M, Berthiaume F. Self-Assembled Fibroblast Growth Factor Nanoparticles as a Therapeutic for Oxidant-Induced Neuronal and Skin Cell Injury. ACS Applied Bio Materials 2024, 7: 5158-5170. PMID: 39038169, DOI: 10.1021/acsabm.4c00135.Peer-Reviewed Original ResearchSpinal cord injuryFGF-2Cell injuryTraumatic brain injurySkin wound healingResponses in vivoInflammatory response in vivoWound healingPressure woundsOxidant-mediated injuryFibroblast growth factor-2Growth factor 2Delayed injuryLocal inflammationNanoparticle sizeChronic skin woundsSecondary complicationsCultured neuronal cellsEndothelial cellsGrowth factorPromote neurite outgrowthCord injuryNeurological sensationsRecombinant fusion proteinNanoparticles
2019
Mouse Model of Pressure Ulcers After Spinal Cord Injury.
Kumar S, Tan Y, Yarmush ML, Dash BC, Hsia HC, Berthiaume F. Mouse Model of Pressure Ulcers After Spinal Cord Injury. Journal Of Visualized Experiments 2019 PMID: 30907872, DOI: 10.3791/58188.Peer-Reviewed Original ResearchConceptsSpinal cord injuryLevel of SCIPressure ulcersSCI miceCord injuryMouse modelComplete spinal cord injuryImpact of SCITraumatic spinal cord injuryComplete spinal cord transectionSpinal cord transectionAdult male miceRelevant mouse modelCord transectionIschemic areaMale miceTissue edemaPU developmentTherapeutic approachesAnimal modelsBony prominencesSuch woundsMiceSoft tissueHealing
2018
Impact of Complete Spinal Cord Injury on Healing of Skin Ulcers in Mouse Models
Kumar S, Yarmush ML, Dash BC, Hsia HC, Berthiaume F. Impact of Complete Spinal Cord Injury on Healing of Skin Ulcers in Mouse Models. Journal Of Neurotrauma 2018, 35: 815-824. PMID: 29160147, DOI: 10.1089/neu.2017.5405.Peer-Reviewed Original ResearchConceptsComplete spinal cord injurySpinal cord injuryPressure ulcersSCI miceSCI groupCord injuryMouse modelControl groupImpact of SCIExcisional woundsTraumatic spinal cord injuryAlpha-smooth muscle actinAdult male miceRelevant mouse modelLower blood vessel densitySuitable animal modelBlood vessel densityFull-thickness excisional woundsDynamics of skinBacks of miceIschemic areaMale miceTissue edemaSkin ulcersAnimal models