2024
Cellular therapeutics and immunotherapies in wound healing – on the pulse of time?
Huelsboemer L, Knoedler L, Kochen A, Yu C, Hosseini H, Hollmann K, Choi A, Stögner V, Knoedler S, Hsia H, Pomahac B, Kauke-Navarro M. Cellular therapeutics and immunotherapies in wound healing – on the pulse of time? Military Medical Research 2024, 11: 23. PMID: 38637905, PMCID: PMC11025282, DOI: 10.1186/s40779-024-00528-5.Peer-Reviewed Original ResearchConceptsStandard of careChronic wound healing disordersLocal wound irrigationWound healingChronic inflammatory microenvironmentFree flap techniqueWound healing disordersChronic woundsGenetic risk profilesPhysiological wound healingAdequate blood supplySurgical debridementFlap techniqueCellular therapyCurrent therapiesHealing disordersInflammatory microenvironmentWound irrigationNon-healing woundsCellular therapeuticsGeneral anesthesiaFormation of biofilmsWound debridementSkin graftsImmunotherapy
2023
Apoptosis recognition receptors regulate skin tissue repair in mice
Justynski O, Bridges K, Krause W, Forni M, Phan Q, Sandoval-Schaefer T, Carter K, King D, Hsia H, Gazes M, Vyce S, Driskell R, Miller-Jensen K, Horsley V. Apoptosis recognition receptors regulate skin tissue repair in mice. ELife 2023, 12: e86269. PMID: 38127424, PMCID: PMC10735221, DOI: 10.7554/elife.86269.Peer-Reviewed Original Research
2020
An in situ collagen‐HA hydrogel system promotes survival and preserves the proangiogenic secretion of hiPSC‐derived vascular smooth muscle cells
Dash BC, Duan K, Xing H, Kyriakides TR, Hsia HC. An in situ collagen‐HA hydrogel system promotes survival and preserves the proangiogenic secretion of hiPSC‐derived vascular smooth muscle cells. Biotechnology And Bioengineering 2020, 117: 3912-3923. PMID: 32770746, DOI: 10.1002/bit.27530.Peer-Reviewed Original ResearchSelf-Assembled Nanomaterials for Chronic Skin Wound Healing
Kang HJ, Chen N, Dash BC, Hsia HC, Berthiaume F. Self-Assembled Nanomaterials for Chronic Skin Wound Healing. Advances In Wound Care 2020, 10: 221-233. PMID: 32487014, PMCID: PMC8024239, DOI: 10.1089/wound.2019.1077.Peer-Reviewed Original ResearchConceptsSelf-assembled nanomaterialsDrug delivery capabilityNanomaterialsWound healing applicationsTunable mechanicsExcellent biocompatibilityMultifunctional propertiesPhysiochemical propertiesMultiple functionalitiesDelivery systemComplex multifunctional structuresDelivery capabilityHealing applicationsWound dressingsPropertiesMultifunctional structuresLow costChronic wound healing applicationsBiocompatibilityGrowth factor delivery systemEffective wound therapyMaterialsDegradationMechanismStructureA Dense Fibrillar Collagen Scaffold Differentially Modulates Secretory Function of iPSC-Derived Vascular Smooth Muscle Cells to Promote Wound Healing
Dash BC, Setia O, Gorecka J, Peyvandi H, Duan K, Lopes L, Nie J, Berthiaume F, Dardik A, Hsia HC. A Dense Fibrillar Collagen Scaffold Differentially Modulates Secretory Function of iPSC-Derived Vascular Smooth Muscle Cells to Promote Wound Healing. Cells 2020, 9: 966. PMID: 32295218, PMCID: PMC7226960, DOI: 10.3390/cells9040966.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsSmooth muscle cellsSecretory functionHuman-induced pluripotent stem cellsParacrine secretionMuscle cellsCollagen fibrillar densitiesSecretory factorsVascular regenerationWound healingTissue-engineered vascular graftsHealingVascular graftsStem cellsPluripotent stem cellsCollagen scaffoldsScaffold propertiesScaffold materialsCellsPromising strategyDisease modelingFibrillar densityRegenerative wound healingCytokinesGraftSafety of compression therapy for venous ulcer disease in the setting of congestive heart failure
Attaran RR, Cavanaugh A, Tsay C, Ahmad T, Chaar C, Persing S, Hsia H. Safety of compression therapy for venous ulcer disease in the setting of congestive heart failure. Phlebology The Journal Of Venous Disease 2020, 35: 556-560. PMID: 32028849, DOI: 10.1177/0268355520905178.Peer-Reviewed Original ResearchConceptsCongestive heart failureCongestive heart failure populationVenous ulcer diseaseHeart failure populationHeart failureCompression therapyUlcer diseaseFailure populationCongestive heart failure exacerbationStable congestive heart failureDiuretic dose increaseHeart failure exacerbationMainstay of treatmentHeart failure decompensationWound care centerLarge teaching hospitalRetrospective reviewCare centerPatient outcomesTeaching hospitalRegistry dataPatientsTherapyWeight gainCompression periodInduced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing
Gorecka J, Gao X, Fereydooni A, Dash BC, Luo J, Lee SR, Taniguchi R, Hsia HC, Qyang Y, Dardik A. Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing. Regenerative Medicine 2020, 15: 1277-1293. PMID: 32228292, PMCID: PMC7304438, DOI: 10.2217/rme-2019-0086.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsMuscle cellsDiabetic wound healingWound healingPro-angiogenic cytokinesMurine AdiposeStem cellsType macrophagesCollagen scaffoldsCultured mediumM2-type macrophagesCellsNumber of totalNew candidatesAngiogenesisNude miceDiabetic woundsPromising new candidateScaffoldsHealingCytokinesExpressionSecreteWoundsAdipose
2019
Evidence-Based Gardening: Using Palliative Approaches to Cure Complex Wounds.
Ching AH, Le N, Norwich-Cavanaugh A, Hsia HC. Evidence-Based Gardening: Using Palliative Approaches to Cure Complex Wounds. Annals Of Plastic Surgery 2019, 83: s45-s49. PMID: 31513065, DOI: 10.1097/sap.0000000000002100.Peer-Reviewed Original ResearchCan Nicotine Replacement Therapy Decrease Complications in Plastic Surgery?
Xu Z, Norwich-Cavanaugh A, Hsia HC. Can Nicotine Replacement Therapy Decrease Complications in Plastic Surgery? Annals Of Plastic Surgery 2019, 83: s55-s58. PMID: 31513067, DOI: 10.1097/sap.0000000000002095.Peer-Reviewed Original ResearchConceptsNicotine replacementHigh-level evidencePlastic surgery proceduresPostoperative periodSurgical patientsCessation therapyClinical outcomesCigarette smokingProspective studySmoking cessationAdverse outcomesDecrease complicationsClinical trialsEffective modalityOptimizing outcomesSurgery proceduresElectronic cigarettesPatient safetyPlastic surgeonsPlastic surgeryComplicationsPatientsOutcomesRiskModalitiesTargeting Fibrotic Signaling: A Review of Current Literature and Identification of Future Therapeutic Targets to Improve Wound Healing.
Hetzler PT, Dash BC, Guo S, Hsia HC. Targeting Fibrotic Signaling: A Review of Current Literature and Identification of Future Therapeutic Targets to Improve Wound Healing. Annals Of Plastic Surgery 2019, 83: e92-e95. PMID: 31246672, PMCID: PMC6851445, DOI: 10.1097/sap.0000000000001955.Peer-Reviewed Original ResearchConceptsTherapeutic targetAberrant wound healing processAppropriate physiologic responseMorbid disease processSurvival of myofibroblastsWound healingFibrotic signaling pathwaysTranscription factor/serum response factor (MRTF/SRF) pathwayFuture therapeutic targetsSmooth muscle actinFuture translational researchCurrent literatureFibrotic signalingTherapeutic optionsFibrotic lesionsTissue injuryWound healing processDisease processPhysiologic responsesSerum response factor pathwayMuscle actinFactor pathwayExcessive responseFibrosisTranslational researchClinical Value of Single-photon Emission Computed Tomography Combined With Computed Tomography for Sentinel Lymph Node Identification in Melanoma.
McGregor A, Kim S, Norwich-Cavanaugh A, Sun AH, Abbate DS, Hsia HC, Narayan D. Clinical Value of Single-photon Emission Computed Tomography Combined With Computed Tomography for Sentinel Lymph Node Identification in Melanoma. Annals Of Plastic Surgery 2019, 82: s192-s194. PMID: 30855387, DOI: 10.1097/sap.0000000000001895.Peer-Reviewed Original ResearchConceptsSPECT/CTSentinel lymph nodesLymph nodesIntraoperative findingsSingle photon emissionSentinel lymphSurgical approachComputed tomographyOperative planPreoperative SPECT/CTSentinel lymph node identificationDistant metastatic diseasePalpable lymph nodesRetrospective chart reviewSentinel node biopsyVeterans Affairs hospitalLymph node identificationIntraoperative lymphoscintigraphyNeck melanomaPrimary endpointChart reviewMetastatic diseaseNode biopsySLN identificationMelanoma patientsAn Algorithm for the Management of Residual Head and Neck Melanoma In Situ Using Topical Imiquimod: A Pilot Study.
Tsay C, Kim S, Norwich-Cavanaugh A, Hsia HC, Narayan D. An Algorithm for the Management of Residual Head and Neck Melanoma In Situ Using Topical Imiquimod: A Pilot Study. Annals Of Plastic Surgery 2019, 82: s199-s201. PMID: 30855388, DOI: 10.1097/sap.0000000000001840.Peer-Reviewed Original ResearchConceptsTopical imiquimodNeck melanomaSurgical excisionCure rateAtypical squamous cell carcinomaComparable cure ratesSquamous cell carcinomaDuration of treatmentLength of treatmentFrequency of treatmentStage T1aActive inflammationStandard therapyInitial biopsyResidual inflammationPatient adherencePositive marginsResidual diseaseCell carcinomaCertain patientsSkin biopsiesComplete excisionFunctional impairmentInclusion criteriaDifficult lesionsThe potential and limitations of induced pluripotent stem cells to achieve wound healing
Gorecka J, Kostiuk V, Fereydooni A, Gonzalez L, Luo J, Dash B, Isaji T, Ono S, Liu S, Lee SR, Xu J, Liu J, Taniguchi R, Yastula B, Hsia HC, Qyang Y, Dardik A. The potential and limitations of induced pluripotent stem cells to achieve wound healing. Stem Cell Research & Therapy 2019, 10: 87. PMID: 30867069, PMCID: PMC6416973, DOI: 10.1186/s13287-019-1185-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic woundsCell therapyStem cellsDiabetic foot ulcersCell typesWound healingInvasive harvesting techniquesAdult-derived stem cellsNormal skin architecturePluripotent stem cellsLimb ischemiaFoot ulcersLimited cell survivalSafety profileOnly cell typeAnimal modelsHuman studiesPotential treatmentPhysiologic responsesHealthy skinImmune rejectionAdvanced therapiesTranslational potentialUse of iPSCsSystemic factors
2018
Impact of Acellular Dermal Matrix on Postsurgical Wound Fluid Biomarkers in Prosthetic Breast Reconstruction
Hsia HC, Weaver MR, Schwarzbauer JE. Impact of Acellular Dermal Matrix on Postsurgical Wound Fluid Biomarkers in Prosthetic Breast Reconstruction. Annals Of Plastic Surgery 2018, 81: s89-s96. PMID: 29851721, DOI: 10.1097/sap.0000000000001495.Peer-Reviewed Original ResearchConceptsAcellular dermal matrixProsthetic breast reconstructionInitial postoperative periodBreast reconstructionDermal matrixPostoperative periodFluid biomarkersTime pointsBody mass indexSurgical wound fluidBreast reconstruction surgeryFluid samplesMatrix metalloproteinase activitySoft tissue reinforcementExtracellular matrix protein levelsPresent groupWound fluid samplesBiologic scaffoldsSingle surgeonMass indexSurgical drainsReconstruction surgeryCell proliferation activityBlinded fashionSimilar demographicsThe Impact of Microbial Communities on Wound Healing
Xu Z, Hsia HC. The Impact of Microbial Communities on Wound Healing. Annals Of Plastic Surgery 2018, 81: 113-123. PMID: 29746280, DOI: 10.1097/sap.0000000000001450.Peer-Reviewed Original ResearchConceptsWound healingVenous insufficiency ulcersHealth care systemClinical factorsDefinitive treatmentDiabetic footPressure ulcersMicrobiome findingsAcute woundsImproved healingEnormous burdenChronic woundsComparison of findingsWound microbiotaBacteriophage therapyCare systemWound microbiomeExact roleWoundsHealingMore studiesUlcersMicrobiome compositionMajor bacteriaMicrobiome
2017
Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer
Chakraborty D, Benham V, Bullard B, Kearney T, Hsia HC, Gibbon D, Demireva EY, Lunt SY, Bernard JJ. Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer. Oncogene 2017, 36: 6668-6679. PMID: 28783178, PMCID: PMC5709202, DOI: 10.1038/onc.2017.278.Peer-Reviewed Original ResearchConceptsAdipose tissueFibroblast growth factor-2 levelsGrowth factor-2 levelsFGFR-1Cancer prevention strategiesEpithelial cellsExcess adipose tissueTumor formationFactor 2 levelsVisceral adipose tissueNovel ex vivo systemSkin tumor formationObese human donorsNon-tumorigenic epithelial cellsSoft agarEx vivo systemGrowth factor receptorAdjuvant therapyEpithelial cell growthVisceral adiposityLevels of FGF2Obese individualsEpidemiological evidenceFibroblast growth factor receptorCancer risk
2016
On Beyond Lidocaine
Hsia HC. On Beyond Lidocaine. Annals Of Plastic Surgery 2016, 77: s66-s69. PMID: 26808738, DOI: 10.1097/sap.0000000000000709.Peer-Reviewed Original Research
2015
SDF‐1 liposomes promote sustained cell proliferation in mouse diabetic wounds
Olekson MA, Faulknor R, Bandekar A, Sempkowski M, Hsia HC, Berthiaume F. SDF‐1 liposomes promote sustained cell proliferation in mouse diabetic wounds. Wound Repair And Regeneration 2015, 23: 711-723. PMID: 26110250, DOI: 10.1111/wrr.12334.Peer-Reviewed Original ResearchConceptsStromal cell-derived factor-1Acellular dermisCell-derived factor-1Cell proliferationRestoration of skinChronic skin woundsImproved wound closurePersistent cell proliferationCommon complicationGranulation tissue thicknessIschemic tissueProper revascularizationDay 28Day 21Diabetic woundsSuch woundsWound closureSkin woundsDermisFactor 1Tissue thicknessWoundsProliferationLocal Anesthetic Use in Tumescent Liposuction
Paik AM, Daniali LN, Lee ES, Hsia HC. Local Anesthetic Use in Tumescent Liposuction. Annals Of Plastic Surgery 2015, 74: 145-151. PMID: 25590254, DOI: 10.1097/sap.0000000000000420.Peer-Reviewed Original Research
2014
The fate of internalized α5 integrin is regulated by matrix-capable fibronectin
Hsia HC, Nair MR, Corbett SA. The fate of internalized α5 integrin is regulated by matrix-capable fibronectin. Journal Of Surgical Research 2014, 191: 268-279. PMID: 25062814, PMCID: PMC4160403, DOI: 10.1016/j.jss.2014.05.084.Peer-Reviewed Original ResearchConceptsFibronectin matrix assemblyΑ5 integrinFibronectin matrixMatrix assemblySpecific lysine residuesMouse embryo fibroblast cellsEmbryo fibroblast cellsExtracellular spaceIntegrin turnoverCytoplasmic tailTissue-remodeling processesAbsence of fibronectinInternalized receptorsLysine residuesReceptor turnoverIntegrinsTissue remodelingUbiquitinationProtein levelsChinese hamsterFibroblast cellsFibronectin dimersWound repairRapid degradationFate