2019
Pioneers in Dermatology and Venereology: an interview with Prof. Irwin Braverman
Braverman I. Pioneers in Dermatology and Venereology: an interview with Prof. Irwin Braverman. Journal Of The European Academy Of Dermatology And Venereology 2019, 33: 2223-2224. PMID: 31779038, DOI: 10.1111/jdv.16040.Peer-Reviewed Original Research
2000
The Cutaneous Microcirculation
Braverman I. The Cutaneous Microcirculation. Journal Of Investigative Dermatology Symposium Proceedings 2000, 5: 3-9. PMID: 11147672, DOI: 10.1046/j.1087-0024.2000.00010.x.Peer-Reviewed Original ResearchConceptsLaser Doppler flowmetryDermal-subcutaneous junctionRed cell fluxDoppler flowmetryCutaneous microcirculationAscending arteriolesMicrovascular segmentsCell fluxHorizontal plexusLight microscopic featuresSmooth muscle cellsUpper horizontal plexusNormal physiologic stateRed blood cellsPapillary loopsPathogenetic mechanismsSkin biopsiesMicrovascular elementsSkin circulationSkin disordersMuscle cellsRetrograde flowArteriolesFlowmetryBlood cells
1999
Protective effects of erythema nodosum in coccidioidomycosis
Braverman I. Protective effects of erythema nodosum in coccidioidomycosis. The Lancet 1999, 353: 168. PMID: 9923870, DOI: 10.1016/s0140-6736(05)77213-5.Peer-Reviewed Original ResearchBiliary Tract Obstruction Secondary to Mycosis Fungoides: A Case Report
Madsen J, Tallini G, Glusac E, Salem R, Braverman I, Robert M. Biliary Tract Obstruction Secondary to Mycosis Fungoides: A Case Report. Journal Of Clinical Gastroenterology 1999, 28: 56-60. PMID: 9916670, DOI: 10.1097/00004836-199901000-00015.Peer-Reviewed Original ResearchConceptsExtrahepatic biliary treeMycosis fungoidesBiliary treeObstructive jaundiceCutaneous T-cell lymphomaMonoclonal T-cell populationMixed lymphocytic infiltratePrevious skin biopsiesBiliary tract obstructionT cell populationsT-cell lymphomaGene rearrangement studiesObstructive symptomsTract obstructionLiver involvementSurgical resectionIsolated involvementLymphocytic infiltrateEndoscopic examinationExtrahepatic ductsAtypical cellsCase reportSkin biopsiesFungoidesMultiple organs
1998
PURPLE (oops! Atrophie blanche) revisited.
Milstone L, Braverman I. PURPLE (oops! Atrophie blanche) revisited. JAMA Dermatology 1998, 134: 1634. PMID: 9875208, DOI: 10.1001/archderm.134.12.1634.Commentaries, Editorials and Letters
1997
The Cutaneous Microcirculation: Ultrastructure and Microanatomical Organization
Braverman I. The Cutaneous Microcirculation: Ultrastructure and Microanatomical Organization. Microcirculation 1997, 4: 329-340. PMID: 9329009, DOI: 10.3109/10739689709146797.Peer-Reviewed Original ResearchConceptsLaser Doppler flowmetryDermal-subcutaneous junctionRed cell fluxCutaneous microcirculationAscending arteriolesMicrovascular segmentsSkin biopsy specimensCell fluxHorizontal plexusLight microscopic featuresSmooth muscle cellsUpper horizontal plexusNormal physiological stateRed blood cellsPapillary loopsBiopsy specimensPathogenetic mechanismsDoppler flowmetryMicrovascular elementsSkin circulationSkin disordersAbility of LDFMuscle cellsRetrograde flowArteriolesTotal skin electron beam therapy followed by adjuvant psoralen/ultraviolet-A light in the management of patients with T1 and T2 cutaneous T-cell lymphoma (mycosis fungoides)
Quirós P, Jones G, Kacinski B, Braverman I, Heald P, Edelson R, Wilson L. Total skin electron beam therapy followed by adjuvant psoralen/ultraviolet-A light in the management of patients with T1 and T2 cutaneous T-cell lymphoma (mycosis fungoides). International Journal Of Radiation Oncology • Biology • Physics 1997, 38: 1027-1035. PMID: 9276369, DOI: 10.1016/s0360-3016(97)00127-2.Peer-Reviewed Original ResearchConceptsTotal skin electron beam therapyDisease-free survivalT2 patientsCrude relapse rateAdjuvant therapyOverall survivalElectron beam therapyRelapse rateEntire cohortMedian disease-free survivalCutaneous T-cell lymphomaBeam therapySalvage of recurrencesAdjuvant systemic therapyEarly-stage patientsManagement of patientsT-cell lymphomaTopical nitrogen mustardDays/weekCombination of therapiesGy/dayTreatments/weekPUVA patientsMedian followSalvage therapy
1996
Additional courses of total skin electron beam therapy in the treatment of patients with recurrent cutaneous T-cell lymphoma
Wilson L, Quiros P, Kolenik S, Heald P, Braverman I, Edelson R, Kacinski B. Additional courses of total skin electron beam therapy in the treatment of patients with recurrent cutaneous T-cell lymphoma. Journal Of The American Academy Of Dermatology 1996, 35: 69-73. PMID: 8682967, DOI: 10.1016/s0190-9622(96)90499-5.Peer-Reviewed Original ResearchConceptsTotal skin electron beam therapyCutaneous T-cell lymphomaRecurrent cutaneous T-cell lymphomaComplete responseT-cell lymphomaElectron beam therapySecond courseMedian disease-free intervalThird courseAdditional coursesBeam therapyDisease-free intervalTreatment of patientsAcceptable risk profileForm of therapyMedian doseMedian survivalMild erythemaPatientsInitial courseTherapyVariety of modalitiesRisk profileEntire groupLocalized radiationRegional vs Systemic Responses to Mental Stress: A Potential Mechanism for Non-Demand-Related Ischemia
Silverman D, Jotkowitz A, Gutter V, Braverman I, O'Connor T. Regional vs Systemic Responses to Mental Stress: A Potential Mechanism for Non-Demand-Related Ischemia. Microvascular Research 1996, 51: 396-399. PMID: 8992237, DOI: 10.1006/mvre.1996.0036.Peer-Reviewed Original Research
1995
Systemic chemotherapy and extracorporeal photochemotherapy for T3 and T4 cutaneous T-cell lymphoma patients who have achieved a complete response to total skin electron beam therapy
Wilson L, Licata A, Braverman I, Edelson R, Heald P, Feldman A, Kacinski B. Systemic chemotherapy and extracorporeal photochemotherapy for T3 and T4 cutaneous T-cell lymphoma patients who have achieved a complete response to total skin electron beam therapy. International Journal Of Radiation Oncology • Biology • Physics 1995, 32: 987-995. PMID: 7607973, DOI: 10.1016/0360-3016(95)00073-8.Peer-Reviewed Original ResearchConceptsTotal skin electron beam therapyDoxorubicin/cyclophosphamideCutaneous T-cell lymphoma patientsAdjuvant doxorubicin/cyclophosphamideT-cell lymphoma patientsExtracorporeal photochemotherapyComplete responseOverall survivalAdjuvant therapyElectron beam therapyAdjuvant regimenFree survivalCTCL patientsLymphoma patientsBeam therapyAddition of chemotherapyAdvanced stage CTCLClinical complete responseSystemic adjuvant therapyGood partial responseSignificant survival benefitBetter overall survivalRelapse-free survivalSoles of feetNontoxic regimenThe Golgi Association of Endothelial Nitric Oxide Synthase Is Necessary for the Efficient Synthesis of Nitric Oxide(∗)
Sessa W, Garca-Cardea G, Liu J, Keh A, Pollock J, Bradley J, Thiru S, Braverman I, Desai K. The Golgi Association of Endothelial Nitric Oxide Synthase Is Necessary for the Efficient Synthesis of Nitric Oxide(∗). Journal Of Biological Chemistry 1995, 270: 17641-17644. PMID: 7543089, DOI: 10.1074/jbc.270.30.17641.Peer-Reviewed Original ResearchConceptsHEK-293 cellsHeterologous expression systemEndothelial nitric oxide synthaseNovel GolgiGolgi associationExpression systemIntracellular signalsCultured endothelial cellsGolgiIntact blood vesselsEnzymeParticulate enzymeProteinEndothelial cellsCellsSynthaseNitric oxide synthaseOxide synthaseBlood vesselsCompartmentalizationNitric oxideTargetHypopigmented variant of mycosis fungoides: Demography, histopathology, and treatment of seven cases
Lambroza E, Cohen S, Phelps R, Lebwohl M, Braverman I, DiCostanzo D. Hypopigmented variant of mycosis fungoides: Demography, histopathology, and treatment of seven cases. Journal Of The American Academy Of Dermatology 1995, 32: 987-993. PMID: 7751470, DOI: 10.1016/0190-9622(95)91337-8.Peer-Reviewed Original ResearchConceptsMycosis fungoidesEpidermal atrophyVariant of MFTreatment of choiceMedian ageMononuclear cellsHistologic findingsBiopsy diagnosisComplete repigmentationDisease onsetTreatment outcomesMF variantDisease processNew casesYoung populationPrior reportsFungoidesPUVAPatientsAtrophyMicroscopic featuresHistopathologyTreatmentDark skinSkinMalignant melanoma and other second cutaneous malignancies in cutaneous T-cell lymphoma. The influence of additional therapy after total skin electron beam radiation.
Licata AG, Wilson LD, Braverman IM, Feldman AM, Kacinski BM. Malignant melanoma and other second cutaneous malignancies in cutaneous T-cell lymphoma. The influence of additional therapy after total skin electron beam radiation. JAMA Dermatology 1995, 131: 432-5. PMID: 7726585, DOI: 10.1001/archderm.131.4.432.Peer-Reviewed Original ResearchConceptsTotal skin electron beam therapyCutaneous T-cell lymphomaT-cell lymphomaSquamous cell carcinomaBasal cell carcinomaElectron beam therapyAdditional radiation therapyCell carcinomaCutaneous malignanciesOral psoralenAdditional therapyMalignant melanomaRadiation therapyBeam therapyTotal skin electron beam radiationFurther radiation therapyGroup of patientsNonmelanoma skin cancerAnecdotal case reportsPrevious large studiesTopical mechlorethamineHydrochloride therapyCase reportPatientsCarcinoma
1994
Unique and Uncommon Skin Signs of Systemic Diseases
Braverman I. Unique and Uncommon Skin Signs of Systemic Diseases. The Journal Of Dermatology 1994, 21: 929-934. PMID: 7868764, DOI: 10.1111/j.1346-8138.1994.tb03314.x.Peer-Reviewed Original ResearchInducibility and Expression of Microvascular Endothelial Adhesion Molecules in Lesional, Perilesional, and Uninvolved Skin of Psoriatic Patients
Petzelbauer P, Pober J, Keh A, Braverman I. Inducibility and Expression of Microvascular Endothelial Adhesion Molecules in Lesional, Perilesional, and Uninvolved Skin of Psoriatic Patients. Journal Of Investigative Dermatology 1994, 103: 300-305. PMID: 7521374, DOI: 10.1111/1523-1747.ep12394720.Peer-Reviewed Original ResearchConceptsVascular cell adhesion molecule-1Endothelial leukocyte adhesion molecule-1Lesional skinAdhesion molecule-1Psoriatic patientsEndothelial cellsUninvolved skinPerilesional skinMolecule-1Dermal microvasculatureCapillary loopsCell adhesion molecule-1Perivascular inflammatory infiltratesLeukocyte adhesion molecule-1VCAM-1 expressionTumor necrosis factorEndothelial adhesion moleculesMicrovascular endothelial cellsEndothelial cell expressionVenular endothelial cellsInflammatory infiltrateEpidermal involvementPsoriatic plaquesSuperficial plexusNecrosis factorSpatial Heterogeneity in Normal Skin Perfusion Recorded with Laser Doppler Imaging and Flowmetry
Wardell K, Braverman I, Silverman D, Nilsson G. Spatial Heterogeneity in Normal Skin Perfusion Recorded with Laser Doppler Imaging and Flowmetry. Microvascular Research 1994, 48: 26-38. PMID: 7990721, DOI: 10.1006/mvre.1994.1036.Peer-Reviewed Original ResearchImpact of non-CTCL dermatologic diagnoses and adjuvant therapies on cutaneous T-cell lymphoma patients treated with total skin electron beam radiation therapy
Wilson L, Cooper D, Goodrich A, Friedman N, Feldman A, Braverman I, Kacinski B. Impact of non-CTCL dermatologic diagnoses and adjuvant therapies on cutaneous T-cell lymphoma patients treated with total skin electron beam radiation therapy. International Journal Of Radiation Oncology • Biology • Physics 1994, 28: 829-837. PMID: 8138435, DOI: 10.1016/0360-3016(94)90102-3.Peer-Reviewed Original ResearchConceptsTotal skin electron beam therapySystemic adjuvant therapyRelapse-free survivalDoxorubicin/cyclophosphamide chemotherapyShorter relapse-free survivalElectron beam therapyAdjuvant therapyDermatologic diagnosesBeam therapyCyclophosphamide chemotherapyFollicular mucinosisOverall survivalT2 patientsExtracorporeal photopheresisLymphomatoid papulosisCutaneous relapseTotal skin electron beam radiation therapyCutaneous T-cell lymphoma patientsT-cell lymphoma patientsBetter relapse-free survivalClinical complete responseCohort of patientsElectron beam radiation therapyBeam radiation therapyAdjuvant chemotherapy
1993
Transformation in Cutaneous T-Cell Lymphoma
Braverman I, Redfern C. Transformation in Cutaneous T-Cell Lymphoma. Journal Of Investigative Dermatology 1993, 101: 249-251. PMID: 8370959, DOI: 10.1111/1523-1747.ep12365124.Peer-Reviewed Original ResearchCyclosporine treatment of refractory T‐cell lymphomas
Cooper D, Braverman I, Sarris A, Durivage H, Saidman B, Davis C, Hait W. Cyclosporine treatment of refractory T‐cell lymphomas. Cancer 1993, 71: 2335-2341. PMID: 8453556, DOI: 10.1002/1097-0142(19930401)71:7<2335::aid-cncr2820710727>3.0.co;2-d.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaPeripheral T-cell lymphomaRefractory T-cell lymphomaT-cell lymphomaMost patientsDisease progressionReinstitution of therapySubsequent graft rejectionPhase II trialT cell expansionT-cell neoplasmsTranscription of cytokinesCyclosporine treatmentClinical remissionII trialPrevious therapyRecurrent diseaseCsA administrationGraft rejectionRenal toxicityAntiinflammatory effectsRapid recurrenceTransplanted organsInterleukin-2Radiation therapy
1992
Human dermatosparaxis: a form of Ehlers-Danlos syndrome that results from failure to remove the amino-terminal propeptide of type I procollagen.
Smith L, Wertelecki W, Milstone L, Petty E, Seashore M, Braverman I, Jenkins T, Byers P. Human dermatosparaxis: a form of Ehlers-Danlos syndrome that results from failure to remove the amino-terminal propeptide of type I procollagen. American Journal Of Human Genetics 1992, 51: 235-44. PMID: 1642226, PMCID: PMC1682688.Peer-Reviewed Original ResearchConceptsAmino-terminal propeptideFragile skinType IConnective tissue disordersEhlers-Danlos syndromeLax jointsType VIIAffected animalsSkinChildrenCultured fibroblastsNormal cellsEhlers-Danlos syndrome type VIIPro alphaDisordersPropeptideAlphaDermatosparaxisProteolytic processingSepsisN-proteinaseCellsSyndromeCollagen fibrils