2024
Pancreatic Cancer Surveillance and Survival of High-Risk Individuals
Blackford A, Canto M, Dbouk M, Hruban R, Katona B, Chak A, Brand R, Syngal S, Farrell J, Kastrinos F, Stoffel E, Rustgi A, Klein A, Kamel I, Fishman E, He J, Burkhart R, Shin E, Lennon A, Goggins M. Pancreatic Cancer Surveillance and Survival of High-Risk Individuals. JAMA Oncology 2024, 10: 1087-1096. PMID: 38959011, PMCID: PMC11223057, DOI: 10.1001/jamaoncol.2024.1930.Peer-Reviewed Original ResearchHigh-risk individualsSurveillance of high-risk individualsScreening programPancreatic ductal adenocarcinomaScreening high-risk individualsPancreatic cancer surveillanceUS academic medical centersPopulation-based screeningConditional logistic regressionUS national dataCox proportional hazards regressionAcademic medical centerLead-time biasProportional hazards regressionYear of diagnosisControl patientsRisk regression modelCancer surveillanceComparative cohort studyMain OutcomesComparison cohortOverall survivalCohort studyHazards regressionNational dataRisk of Pancreatitis After Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Pancreatic Cystic Lesions: A Systematic Review and Meta-Analysis
Magahis P, Chhoda A, Berzin T, Farrell J, Wright D, Rizvi A, Hanscom M, Carr-Locke D, Sampath K, Sharaiha R, Mahadev S. Risk of Pancreatitis After Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Pancreatic Cystic Lesions: A Systematic Review and Meta-Analysis. The American Journal Of Gastroenterology 2024, 119: 2174-2186. PMID: 38976379, DOI: 10.14309/ajg.0000000000002942.Peer-Reviewed Original ResearchPancreatic cystic lesionsPancreatitis riskSystematic reviewEUS-TTNBRisk factorsCystic lesionsDerSimonian-Laird methodEnglish-language studiesEndoscopic ultrasound-guided fine-needle aspirationRandom-effects modelUltrasound-guided fine-needle aspirationRisk of post-procedure pancreatitisPredisposing characteristicsFine-needle-aspirationRisk of pancreatitisFine-needle aspirationPost-procedure pancreatitisLaird methodMeta-regressionSystematic searchPooled riskMeta-analyzedMeta-analysisPancreatitis eventsNeedle aspirationDisparities in race, ethnicity, sex, and age inclusion in pancreatic cancer screening studies: a systematic review and meta-analysis
Silva-Santisteban A, Hernandez Woodbine M, Noriega M, Rabinowitz L, Grimshaw A, Farrell J, Chhoda A, Sawhney M. Disparities in race, ethnicity, sex, and age inclusion in pancreatic cancer screening studies: a systematic review and meta-analysis. Gastrointestinal Endoscopy 2024, 100: 1-16.e20. PMID: 38432492, DOI: 10.1016/j.gie.2024.02.014.Peer-Reviewed Original ResearchCancer screening studyPopulation-based benchmarksPancreatic cancer screeningProportion of study participantsScreening studiesPancreatic cancer outcomesAge reportingInclusion of participantsMedian participant ageCancer screeningCancer outcomesStudy qualityWeb of Science Core CollectionNon-LatinoStudy participantsParticipant agePancreatic cancer studiesYear of publicationOvid MEDLINEGeneral populationSystematic reviewMeta-regressionSystematic searchScience Core CollectionOvid Embase
2023
Clinical predictive value of renalase in post-ERCP pancreatitis
Muniraj T, Desir G, Gorelick F, Guo X, Ciarleglio M, Deng Y, Jamidar P, Farrell J, Aslanian H, Laine L. Clinical predictive value of renalase in post-ERCP pancreatitis. Gastrointestinal Endoscopy 2023, 99: 822-825.e1. PMID: 38103747, DOI: 10.1016/j.gie.2023.12.020.Peer-Reviewed Original ResearchPost-ERCP pancreatitisRenalase levelsPlasma renalase levelsProspective cohort studyPotential clinical roleAcute experimental pancreatitisLongitudinal regression modelsPEP patientsPlasma renalaseCohort studyTertiary hospitalClinical roleExperimental pancreatitisRenalaseAbstractTextERCPPancreatitisFurther studiesAIMSRegression modelsUtility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms
Chhoda A, Sharma A, Sailo B, Tang H, Ruzgar N, Tan W, Ying L, Khatri R, Narayanan A, Mane S, De Kumar B, Wood L, Iacobuzio-Donahue C, Wolfgang C, Kunstman J, Salem R, Farrell J, Ahuja N. Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms. Clinical Epigenetics 2023, 15: 28. PMID: 36803844, PMCID: PMC9942382, DOI: 10.1186/s13148-023-01429-5.Peer-Reviewed Original ResearchConceptsPapillary mucinous neoplasmMalignant risk stratificationCACNA1G geneRisk stratificationMucinous neoplasmsBiomarker panelBackgroundIntraductal papillary mucinous neoplasmIntraductal papillary mucinous neoplasmEarly detectionPrevious case-control studyHigh-grade dysplasiaCase-control studyPancreatic cancer precursorsReceiver Operating Characteristic (ROC) curve analysisSignificant diagnostic challengeCross-sectional imagingCharacteristic curve analysisOperating Characteristic curve analysisG geneHigh diagnostic specificityPrior validation studiesSignificant procedural riskIPMN tissuesSurgical resectionAdvanced neoplasiaRacial, ethnic, and sex-based disparities among high-risk individuals undergoing pancreatic cancer surveillance.
Klute K, Lucas A, Brand R, Everett J, Farrell J, Hawthorne K, Kaul V, Kupfer S, Paiella S, Simeone D, Sussman D, Zogopoulos G, Kastrinos F, Katona B, Consortium A. Racial, ethnic, and sex-based disparities among high-risk individuals undergoing pancreatic cancer surveillance. Journal Of Clinical Oncology 2023, 41: 687-687. DOI: 10.1200/jco.2023.41.4_suppl.687.Peer-Reviewed Original ResearchHigh-risk individualsSex-based disparitiesFamilial pancreatic cancerPDAC surveillancePancreatic cancer surveillancePeutz-Jeghers syndromeRates of consentSex-based differencesMedian ageAshkenazi Jewish ancestryMulticenter studyProspective studyCancer surveillancePancreatic cancerFamily historyLarge cohortMelanoma syndromeHereditary pancreatitisEarly detection researchStudy participantsEarly detectionStudy periodGermline DNACohortPDACPancreatic imaging findings from the PRECEDE study: A large high-risk heritable cohort for pancreatic cancer.
Haimi I, Zogopoulos G, Dettwyler S, Everett J, Bi Y, Brand R, Chung D, Farrell J, Grossberg A, Kastrinos F, Katona B, Klute K, Kupfer S, Lucas A, Paiella S, Parmigiani G, Permuth J, Sears R, Sussman D, Simeone D, Consortium P. Pancreatic imaging findings from the PRECEDE study: A large high-risk heritable cohort for pancreatic cancer. Journal Of Clinical Oncology 2023, 41: 689-689. DOI: 10.1200/jco.2023.41.4_suppl.689.Peer-Reviewed Original ResearchHigh-risk individualsPancreatic ductal adenocarcinomaPathogenic germline variantsFamilial pancreatic cancerCohort 1Worrisome featuresPancreatic cancerMain pancreatic duct diameterSolid massPancreatic duct diameterStandardized image acquisitionPGV groupGermline testingDuct stricturesIncurable stageMultiple cystsPancreatic abnormalitiesStandardized data collection systemNeuroendocrine tumorsDuctal adenocarcinomaCommon abnormalityFamily historyBenign lesionsLethal cancersPDAC riskPrecision Medicine for Pancreas Cancer Treatment: A Multidisciplinary Challenge or Opportunity?
Farrell J, Robert M, Lacy J. Precision Medicine for Pancreas Cancer Treatment: A Multidisciplinary Challenge or Opportunity? Clinical Gastroenterology And Hepatology 2023, 21: 2740-2742. PMID: 36640803, DOI: 10.1016/j.cgh.2022.12.033.Peer-Reviewed Original Research
2022
Reply to S. Raoof
Dbouk M, Katona B, Brand R, Chak A, Syngal S, Farrell J, Kastrinos F, Stoffel E, Canto M, Goggins M. Reply to S. Raoof. Journal Of Clinical Oncology 2022, 41: 1147-1149. PMID: 36315911, PMCID: PMC9928686, DOI: 10.1200/jco.22.01915.Peer-Reviewed Original ResearchSURVEILLANCE OF HIGH-RISK INDIVIDUALS LEADS TO LOWER STAGE PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) AT DIAGNOSIS AND IMPROVED OVERALL AND DISEASE-SPECIFIC SURVIVAL
Blackford A, Canto M, Dbouk M, Kerdsirichairat T, Chak A, Brand R, Farrell J, Kastrinos F, Katona B, Rustgi A, Stoffel E, Syngal S, Klein A, Hruban R, Goggins M. SURVEILLANCE OF HIGH-RISK INDIVIDUALS LEADS TO LOWER STAGE PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) AT DIAGNOSIS AND IMPROVED OVERALL AND DISEASE-SPECIFIC SURVIVAL. Gastrointestinal Endoscopy 2022, 95: ab544-ab545. DOI: 10.1016/j.gie.2022.04.1334.Peer-Reviewed Original ResearchThe PRECEDE consortium: A longitudinal international cohort study of individuals with genetic risk or familial pancreatic cancer.
Zogopoulos G, Bi Y, Brand R, Chung D, Earl J, Farrell J, Graff J, Kastrinos F, Katona B, Klute K, Koptiuch C, Kupfer S, Kwon R, Lindberg J, Lowy A, Lucas A, Paiella S, Permuth J, Sears R, Simeone D, Consortium T. The PRECEDE consortium: A longitudinal international cohort study of individuals with genetic risk or familial pancreatic cancer. Journal Of Clinical Oncology 2022, 40: e16239-e16239. DOI: 10.1200/jco.2022.40.16_suppl.e16239.Peer-Reviewed Original ResearchPancreatic ductal adenocarcinomaPathogenic germline variantsFamilial pancreatic cancerCancer predisposition genesCohort studyPancreatic cancerClinical dataAnnual surveillanceEffective early detection strategiesHigh-quality clinical dataHigh-risk premalignant lesionsModifiers of riskInternational cohort studyProspective cohort studyEarly-stage diseaseOverall survival rateEarly detection strategiesEarly-stage cancerBlood sample collectionRelevant clinical populationContribution of heritabilityPenetrance of diseaseQuality clinical dataParticipants ages 18Germline testing1061: PANCREATIC CANCER STAGE IN THE MULTICENTER CANCER OF THE PANCREAS SCREENING COHORT
Dbouk M, Chak A, Brand R, Farrell J, Kastrinos F, Katona B, Rustgi A, Kwon R, Stoffel E, Syngal S, Shin E, Canto M, Goggins M. 1061: PANCREATIC CANCER STAGE IN THE MULTICENTER CANCER OF THE PANCREAS SCREENING COHORT. Gastroenterology 2022, 162: s-242-s-243. DOI: 10.1016/s0016-5085(22)60577-8.Peer-Reviewed Original ResearchMo1131: HIGHLY SPECIFIC PROMOTER METHYLATION MARKERS FOR MALIGANT STRATIFICATION OF INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS
Chhoda A, Sharma A, Tang H, Tan W, Sailo B, Peters N, Ying L, Ruzgar N, Kunstman J, Salem R, Farrell J, Ahuja N. Mo1131: HIGHLY SPECIFIC PROMOTER METHYLATION MARKERS FOR MALIGANT STRATIFICATION OF INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS. Gastroenterology 2022, 162: s-708. DOI: 10.1016/s0016-5085(22)61664-0.Peer-Reviewed Original ResearchTu1185: DOES CURRENT EVIDENCE SUPPORT CYST GROWTH RATE AS A WORRISOME FEATURE? A SYSTEMATIC REVIEW AND META-ANALYSIS
Singh S, Chhoda A, Vodusek Z, Khatri R, Gunderson C, McCarty T, Sharma P, Grimshaw A, Kunstman J, Sharma A, Ahuja N, Gonda T, Farrell J. Tu1185: DOES CURRENT EVIDENCE SUPPORT CYST GROWTH RATE AS A WORRISOME FEATURE? A SYSTEMATIC REVIEW AND META-ANALYSIS. Gastroenterology 2022, 162: s-907. DOI: 10.1016/s0016-5085(22)62148-6.Peer-Reviewed Original Research1147: DISPARITIES IN TIME TO TREATMENT INITIATION IN COLORECTAL CANCER IN THE US FROM 2004-2018: ANALYSIS OF THE NATIONAL CANCER DATABASE
Khatri R, Chhoda A, Sharma A, Farrell J, Ahuja N, Ehrlich A, Friedenberg F. 1147: DISPARITIES IN TIME TO TREATMENT INITIATION IN COLORECTAL CANCER IN THE US FROM 2004-2018: ANALYSIS OF THE NATIONAL CANCER DATABASE. Gastroenterology 2022, 162: s-270-s-271. DOI: 10.1016/s0016-5085(22)60641-3.Peer-Reviewed Original Research
2021
S1030 Prevalence and Predictors of Musculoskeletal Disorders Amongst Nurses and Technicians Assisting in ERCP
Mbachi C, Jamidar P, Muniraj T, Farrell J, , Campbell E, Aslanian H. S1030 Prevalence and Predictors of Musculoskeletal Disorders Amongst Nurses and Technicians Assisting in ERCP. The American Journal Of Gastroenterology 2021, 116: s489-s489. DOI: 10.14309/01.ajg.0000777652.16974.b4.Peer-Reviewed Original ResearchID: 3524866 ENDOSCOPIC ULTRASOUND - FINE NEEDLE BIOPSY (EUS-FNB) DERIVED HUMAN ORGANOID MODELS IN PANCREATIC CANCER: CLINICAL AND TECHNICAL PREDICTORS OF SUCCESS
Yoo J, Nair G, Shorr E, LaComb J, Kesar V, Foster G, Joshi N, Farrell J, Buscaglia J. ID: 3524866 ENDOSCOPIC ULTRASOUND - FINE NEEDLE BIOPSY (EUS-FNB) DERIVED HUMAN ORGANOID MODELS IN PANCREATIC CANCER: CLINICAL AND TECHNICAL PREDICTORS OF SUCCESS. Gastrointestinal Endoscopy 2021, 93: ab247-ab248. DOI: 10.1016/j.gie.2021.03.535.Peer-Reviewed Original ResearchID: 3527197 ENDOSCOPIC ULTRASOUND SHEAR WAVE ELASTOGRAPHY (SWE) FOR HIGH RISK INDIVIDUAL PANCREATIC CANCER SURVEILLANCE: A PILOT STUDY
Chhoda A, Merenda S, Farrell J. ID: 3527197 ENDOSCOPIC ULTRASOUND SHEAR WAVE ELASTOGRAPHY (SWE) FOR HIGH RISK INDIVIDUAL PANCREATIC CANCER SURVEILLANCE: A PILOT STUDY. Gastrointestinal Endoscopy 2021, 93: ab262-ab263. DOI: 10.1016/j.gie.2021.03.561.Peer-Reviewed Original ResearchID: 3522469 RISK OF COVID-19 TRANSMISSION AND OUTCOMES IN HEALTHCARE WORKERS PRESENT DURING GASTROINTESTINAL ENDOSCOPIC PROCEDURES: AN INTERNATIONAL MULTICENTER STUDY
Nair G, Yoo J, Vanella G, Angeletti S, Mauro A, Zingone F, Toma A, Pouillon L, Papanikolaou I, Boskoski I, Bronswijk M, Capurso G, Dilaghi E, Di Sabatino A, Savarino E, Fracasso P, Matteo M, Van Der Merwe S, Petrone M, Di Giulio E, Roelandt P, Arcidiacono P, Costamagna G, Farrell J. ID: 3522469 RISK OF COVID-19 TRANSMISSION AND OUTCOMES IN HEALTHCARE WORKERS PRESENT DURING GASTROINTESTINAL ENDOSCOPIC PROCEDURES: AN INTERNATIONAL MULTICENTER STUDY. Gastrointestinal Endoscopy 2021, 93: ab45-ab46. PMCID: PMC8149182, DOI: 10.1016/j.gie.2021.03.152.Peer-Reviewed Original ResearchSa293 ASSESSMENT OF PROGRESSION OF CHRONIC PANCREATITIS-LIKE LESIONS IN HIGH RISK INDIVIDUALS UNDERGOING PANCREATIC CANCER SURVEILLANCE
Chhoda A, Merenda S, Farrell J. Sa293 ASSESSMENT OF PROGRESSION OF CHRONIC PANCREATITIS-LIKE LESIONS IN HIGH RISK INDIVIDUALS UNDERGOING PANCREATIC CANCER SURVEILLANCE. Gastroenterology 2021, 160: s-473-s-474. DOI: 10.1016/s0016-5085(21)01836-9.Peer-Reviewed Original Research