2023
Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression
Jajosky R, Patel K, Allen J, Zerra P, Chonat S, Ayona D, Maier C, Morais D, Wu S, Luckey C, Eisenbarth S, Roback J, Fasano R, Josephson C, Manis J, Chai L, Hendrickson J, Hudson K, Arthur C, Stowell S. Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression. Blood 2023, 142: 1082-1098. PMID: 37363865, PMCID: PMC10541552, DOI: 10.1182/blood.2022018591.Peer-Reviewed Original ResearchConceptsAntibody-mediated immunosuppressionRBC alloantigensImmune responseFetal red blood cell antigensTarget antigenRed blood cell antigensRh immune globulinMaternal immune responseBlood cell antigensInclusion of antibodiesRBC removalAnti-RhD antibodiesAbility of antibodiesImmune globulinAntibody responseHemolytic diseaseRBC clearanceCell antigensFetal RBCsAntibody characteristicsAlloantigensSimilar interventionsAntibodiesAntigenPolyclonal antibody preparationPrior immunization against an intracellular antigen enhances subsequent red blood cell alloimmunization in mice
Jajosky R, Patel S, Wu S, Patel K, Covington M, Vallecillo-Zúniga M, Ayona D, Bennett A, Luckey C, Hudson K, Hendrickson J, Eisenbarth S, Josephson C, Zerra P, Stowell S, Arthur C. Prior immunization against an intracellular antigen enhances subsequent red blood cell alloimmunization in mice. Blood 2023, 141: 2642-2653. PMID: 36638335, PMCID: PMC10356576, DOI: 10.1182/blood.2022016588.Peer-Reviewed Original ResearchConceptsCD4 T cell responsesT cell responsesIntracellular antigensB cellsImmune primingRed blood cell alloimmunizationBlood cell alloantigensRate of alloimmunizationAdditional alloantibodiesAlloimmunization rateRBC alloantigensSubsequent transfusionsSame alloantigensPrior immunizationTransfusion recipientsDonor RBCsMouse modelNumerous antigensRBC antigensAlloantigensAlloimmunizationAntigenTransfusionAlloantibodiesRBCs
2015
Innate and adaptive immune responses to transfused alloantigens
Zimring J, Hudson K, Hendrickson J. Innate and adaptive immune responses to transfused alloantigens. Pathology 2015, 47: s41. DOI: 10.1097/01.pat.0000461433.20240.46.Peer-Reviewed Original ResearchInnate immune activationRed blood cellsImmune activationMurine modelToll-like receptor agonistsAdaptive immune responsesExposure of recipientsRBC alloantigensSubsequent transfusionsMultiple transfusionsRBC alloantibodiesRBC transfusionTLR agonistsReceptor agonistImmune responseMouse modelTransfusionHuman studiesInnate immunityAlloimmunisationAlloantigensBlood cellsSuch exposureRecipientsAgonistsInnate and adaptive immune responses to transfused alloantigens
Zimring J, Hudson K, Hendrickson J. Innate and adaptive immune responses to transfused alloantigens. Pathology 2015, 47: s34. DOI: 10.1097/01.pat.0000461421.80336.37.Peer-Reviewed Original ResearchInnate immune activationRed blood cellsImmune activationMurine modelToll-like receptor agonistsAdaptive immune responsesExposure of recipientsRBC alloantigensSubsequent transfusionsMultiple transfusionsRBC alloantibodiesRBC transfusionTLR agonistsReceptor agonistImmune responseMouse modelTransfusionHuman studiesInnate immunityAlloimmunisationAlloantigensBlood cellsSuch exposureRecipientsAgonists