2015
Antigen Density Impacts RBC Survival and Antigen Modulation Following Incompatible RBC Transfusion
Yoo J, Arthur C, Zerra P, Girard-Pierce K, Hendrickson J, Stowell S. Antigen Density Impacts RBC Survival and Antigen Modulation Following Incompatible RBC Transfusion. Blood 2015, 126: 2350. DOI: 10.1182/blood.v126.23.2350.2350.Peer-Reviewed Original ResearchIncompatible RBC transfusionHemolytic transfusion reactionsWild-type C57BL/6 miceRBC transfusionIncompatible transfusionsAntigen densityAntigen modulationFlow cytometric analysisKEL antigenRBC survivalKEL RBCsImmunized recipientsAntigen levelsCytometric analysisFatal hemolytic transfusion reactionRecipient WT miceChronic transfusion therapyTransfusion of RBCsNon-immunized miceLow antigen densityAntibody-mediated removalAlloimmunized individualsAdverse eventsDonor antigensPost transfusion
2014
Reticuloendothelial Saturation Dictates the Development of RBC Resistance to Antibody-Mediated Clearance Following Incompatible Transfusion
Arthur C, Mener A, Patel S, Rodrigues L, Xue C, Nickel R, Zimring J, Hendrickson J, Stowell S. Reticuloendothelial Saturation Dictates the Development of RBC Resistance to Antibody-Mediated Clearance Following Incompatible Transfusion. Blood 2014, 124: 1559. DOI: 10.1182/blood.v124.21.1559.1559.Peer-Reviewed Original ResearchIncompatible RBC transfusionRed blood cellsRBC transfusionInitial transfusionRBC clearanceAntigen modulationOld red blood cellsAntibody-mediated removalFlow cytometric analysisHOD antigenIncompatible transfusionsDetectable antigenRBC ageReticuloendothelial systemCytometric analysisPreferential clearanceAntibody-Mediated ClearanceRBC-specific antibodiesAntibody-opsonized cellsPhagocytic removalTransfused cellsC57BL/6 recipientsAntigen levelsFVB miceRecipient miceCD8+ T Cells Mediate Antibody-Independent Platelet Clearance Following Transfusion
Patel S, Arthur C, Rodrigues L, Xue C, Zimring J, Hendrickson J, Stowell S. CD8+ T Cells Mediate Antibody-Independent Platelet Clearance Following Transfusion. Blood 2014, 124: 596. DOI: 10.1182/blood.v124.21.596.596.Peer-Reviewed Original ResearchPlatelet-rich plasmaMajor histocompatibility complexNK cell depletionT cellsPlatelet clearanceC57BL/6 recipientsPlatelet transfusionsNK cellsCellular immunityCell depletionAnti-MHC antibodiesSubsequent blood transfusionDepletion of CD8Solid organ allograftsAnti-platelet antibodiesCD8 T cellsClearance of plateletsPlatelet transfusion therapyFlow cytometric analysisLater time pointsC57BL/6 donorsMHC alloantibodiesNK1.1 antibodyOrgan allograftsBlood transfusion
2013
Transfusion Of RBCs With Low-Density KEL Induces Tolerance To The KEL Antigen
Stowell S, Arthur C, Smith N, Girard-Pierce K, Zimring J, Hendrickson J. Transfusion Of RBCs With Low-Density KEL Induces Tolerance To The KEL Antigen. Blood 2013, 122: 1160. DOI: 10.1182/blood.v122.21.1160.1160.Peer-Reviewed Original ResearchKEL RBCsRBC transfusionAntibody formationKEL antigenDetectable IgMRBC alloimmunizationWestern blot analysisC57BL/6 recipientsAntigen densityDay 3RBC antigensDays post transfusionTransfusion of RBCsSubsequent responseBlot analysisFlow cytometric analysisAnalysis of serumCompatible RBCsRBC alloantigensRepeat transfusionPost transfusionAntigen levelsImmunological outcomesRBC exposureSpecific alloantibodiesStorage-Induced Clearance Of RBCs Following Transfusion Occurs Independent Of RBC Age
Arthur C, Smith N, Zimring J, Hendrickson J, Stowell S. Storage-Induced Clearance Of RBCs Following Transfusion Occurs Independent Of RBC Age. Blood 2013, 122: 792. DOI: 10.1182/blood.v122.21.792.792.Peer-Reviewed Original ResearchOld RBCsPost transfusionPositive RBCsEnhanced clearanceRBC ageCytometric analysisPreferential clearanceCitrate phosphate dextrose adenineDays post transfusionPercent of RBCsRBC removalRed blood cell storageClearance of RBCsFlow cytometric analysisTransfused RBCsB6 miceDonor RBCsTransfusionSenescent markersRBC clearanceGradual clearanceClearance phaseRapid clearanceClearanceStored RBCs