2018
Gadolinium Retention: A Research Roadmap from the 2018 NIH/ACR/RSNA Workshop on Gadolinium Chelates
McDonald R, Levine D, Weinreb J, Kanal E, Davenport M, Ellis J, Jacobs P, Lenkinski R, Maravilla K, Prince M, Rowley H, Tweedle M, Kressel H. Gadolinium Retention: A Research Roadmap from the 2018 NIH/ACR/RSNA Workshop on Gadolinium Chelates. Radiology 2018, 289: 517-534. PMID: 30204075, PMCID: PMC6209069, DOI: 10.1148/radiol.2018181151.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsContrast MediaGadoliniumHumansNational Institutes of Health (U.S.)RadiologyResearchSocieties, MedicalUnited StatesConceptsGadolinium retentionLong-term clinical manifestationsConstellation of symptomsGBCA exposureClinical manifestationsHuman tissuesSafety profileClinical diseaseInitial approvalClinical importanceGBCA administrationGreater riskBiologic activityVulnerable populationsStandardized studiesImaging modalitiesNational InstituteLinear GBCAsGBCAsSymptomsCurrent literatureDiseaseAdditional researchFuture research initiativesMedical information
2017
Negative Multiparametric Magnetic Resonance Imaging of the Prostate Predicts Absence of Clinically Significant Prostate Cancer on 12-Core Template Prostate Biopsy
Lu AJ, Syed JS, Nguyen KA, Nawaf CB, Rosoff J, Spektor M, Levi A, Humphrey PA, Weinreb JC, Schulam PG, Sprenkle PC. Negative Multiparametric Magnetic Resonance Imaging of the Prostate Predicts Absence of Clinically Significant Prostate Cancer on 12-Core Template Prostate Biopsy. Urology 2017, 105: 118-122. PMID: 28322902, DOI: 10.1016/j.urology.2017.01.048.Peer-Reviewed Original ResearchConceptsMultiparametric magnetic resonance imagingSignificant prostate cancerProstate cancerNegative predictive valueMagnetic resonance imagingSystematic TRUSNegative mpMRIProstate biopsyNegative multiparametric magnetic resonance imagingPredictive valueResonance imagingClinically Significant Prostate CancerDynamic contrast enhancement sequencesTemplate mapping biopsyPrior negative biopsySystematic prostate biopsyOverall cancer detectionProstate-specific antigenTemplate prostate biopsyProstate cancer detectionDiffusion-weighted imagingCancer detectionBiopsy naïveMapping biopsyProstate volume
2013
ACR guidance document on MR safe practices: 2013
Safety: P, Kanal E, Barkovich A, Bell C, Borgstede J, Bradley W, Froelich J, Gimbel J, Gosbee J, Kuhni‐Kaminski E, Larson P, Lester J, Nyenhuis J, Schaefer D, Sebek E, Weinreb J, Wilkoff B, Woods T, Lucey L, Hernandez D. ACR guidance document on MR safe practices: 2013. Journal Of Magnetic Resonance Imaging 2013, 37: 501-530. PMID: 23345200, DOI: 10.1002/jmri.24011.Peer-Reviewed Original Research
2001
MR Renography with Low-Dose Gadopentetate Dimeglumine: Feasibility
Lee V, Rusinek H, Johnson G, Rofsky N, Krinsky G, Weinreb J. MR Renography with Low-Dose Gadopentetate Dimeglumine: Feasibility. Radiology 2001, 221: 371-9. PMID: 11687678, DOI: 10.1148/radiol.2212010142.Peer-Reviewed Original ResearchConceptsRenal artery stenosisACE inhibitorsCreatinine levelsIntravenous injectionMedullary enhancementMR renographyAngiotensin converting enzyme (ACE) inhibitorsGadopentetate dimeglumineMR angiographyContrast material-enhanced MR angiographyElevated creatinine levelSerum creatinine levelsMaterial-enhanced MR angiographyConverting Enzyme InhibitorsGadolinium-enhanced MR angiographyRenographic findingsRenovascular diseaseRenal functionArtery stenosisRenal cortexPatientsEnzyme inhibitorsContrast materialClinical settingRenographyMR imaging as the sole preoperative imaging modality for right hepatectomy: a prospective study of living adult-to-adult liver donor candidates.
Lee V, Morgan G, Teperman L, John D, Diflo T, Pandharipande P, Berman P, Lavelle M, Krinsky G, Rofsky N, Schlossberg P, Weinreb J. MR imaging as the sole preoperative imaging modality for right hepatectomy: a prospective study of living adult-to-adult liver donor candidates. American Journal Of Roentgenology 2001, 176: 1475-82. PMID: 11373217, DOI: 10.2214/ajr.176.6.1761475.Peer-Reviewed Original ResearchConceptsLiver donor candidatesSole preoperative imaging modalityPreoperative imaging modalitiesRight hepatectomyDonor candidatesExtrahepatic abnormalitiesConventional angiographyMR imagingPreoperative imaging testsRight lobe transplantationSuccessful right hepatectomyHepatic venous anatomyImaging modalitiesMR angiographic findingsIntrahepatic biliary anatomyBasis of MRMR imaging findingsMR imaging examinationsT2-weighted imagingMeasurements of rightFeasibility of MRCholangiography findingsAngiographic findingsHepatic arteryImaging findingsDevelopment, standardization, and testing of a lexicon for reporting contrast‐enhanced breast magnetic resonance imaging studies
Ikeda D, Hylton N, Kinkel K, Hochman M, Kuhl C, Kaiser W, Weinreb J, Smazal S, Degani H, Viehweg P, Barclay J, Schnall M. Development, standardization, and testing of a lexicon for reporting contrast‐enhanced breast magnetic resonance imaging studies. Journal Of Magnetic Resonance Imaging 2001, 13: 889-895. PMID: 11382949, DOI: 10.1002/jmri.1127.Peer-Reviewed Original ResearchConceptsLesion typeUnweighted kappa statisticClinical historyInternal enhancement characteristicsBreast densityBreast MRIBreast magnetic resonance imaging (MRI) examinationsInterobserver agreementMagnetic resonance imaging examinationsMagnetic resonance imaging studyKappa statisticsRadiology Breast ImagingResonance imaging studyModerate interobserver agreementEnhancement characteristicsBreast MRI studiesMass lesionRim enhancementImaging examinationsAmerican CollegeMRI reportingMRI studiesMRI experienceImaging studiesLike enhancementVolumetric mangafodipir trisodium-enhanced cholangiography to define intrahepatic biliary anatomy.
Lee V, Rofsky N, Morgan G, Teperman L, Krinsky G, Berman P, Weinreb J. Volumetric mangafodipir trisodium-enhanced cholangiography to define intrahepatic biliary anatomy. American Journal Of Roentgenology 2001, 176: 906-8. PMID: 11264075, DOI: 10.2214/ajr.176.4.1760906.Peer-Reviewed Original ResearchDynamic contrast-enhanced three-dimensional MR imaging of liver parenchyma: source images and angiographic reconstructions to define hepatic arterial anatomy.
Lavelle M, Lee V, Rofsky N, Krinsky G, Weinreb J. Dynamic contrast-enhanced three-dimensional MR imaging of liver parenchyma: source images and angiographic reconstructions to define hepatic arterial anatomy. Radiology 2001, 218: 389-94. PMID: 11161151, DOI: 10.1148/radiology.218.2.r01fe31389.Peer-Reviewed Original Research
2000
Efficacy and safety of mangafodipir trisodium (MnDPDP) injection for hepatic MRI in adults: Results of the U.S. Multicenter phase III clinical trials. Efficacy of early imaging
Federle M, Chezmar J, Rubin D, Weinreb J, Freeny P, Schmiedl U, Brown J, Borrello J, Lee J, Semelka R, Mattrey R, Dachman A, Saini S, Harms S, Mitchell D, Anderson M, Halford H, Bennett W, Young S, Rifkin M, Gay S, Ballerini R, Sherwin P, Robison R. Efficacy and safety of mangafodipir trisodium (MnDPDP) injection for hepatic MRI in adults: Results of the U.S. Multicenter phase III clinical trials. Efficacy of early imaging. Journal Of Magnetic Resonance Imaging 2000, 12: 689-701. PMID: 11050638, DOI: 10.1002/1522-2586(200011)12:5<689::aid-jmri5>3.0.co;2-z.Peer-Reviewed Original ResearchConceptsUnenhanced magnetic resonance imagingMagnetic resonance imagingMangafodipir trisodium injectionFinal diagnosisMulticenter phase III clinical trialContrast-enhanced computed tomography examinationPhase III clinical trialsContrast-enhanced magnetic resonance imagingInjection of MnDPDPPatient's final diagnosisHepatic magnetic resonance imagingComputed tomography examinationEnhanced magnetic resonance imagingFocal liver diseaseAdditional diagnostic informationFocal liver lesionsLiver diseaseEarly imagingMRI evaluationHepatic massClinical trialsTomography examinationIntravenous administrationPatient managementRadiologic diagnosisPelvic arteriovenous malformations: gadolinium-enhanced three-dimensional MR angiography findings
Candamio M, Lee V, Rofsky N, Krinsky G, Weinreb J. Pelvic arteriovenous malformations: gadolinium-enhanced three-dimensional MR angiography findings. European Radiology 2000, 10: 1257-1260. PMID: 10939485, DOI: 10.1007/s003300000329.Peer-Reviewed Original ResearchSafety and Efficacy of Mangafodipir Trisodium (MnDPDP) Injection for Hepatic MRI in Adults: Results of the U.S. Multicenter Phase III Clinical Trials (Safety)
Federle M, Chezmar J, Rubin D, Weinreb J, Freeny P, Semelka R, Brown J, Borrello J, Lee J, Mattrey R, Dachman A, Saini S, Harmon B, Fenstermacher M, Pelsang R, Harms S, Mitchell D, Halford H, Anderson M, Johnson C, Francis I, Bova J, Kenney P, Klippenstein D, Foster G, Turner D, Stillman A, Nelson R, Young S, Patt R, Rifkin M, Seltzer S, Gay S, Robison R, Sherwin P, Ballerini R. Safety and Efficacy of Mangafodipir Trisodium (MnDPDP) Injection for Hepatic MRI in Adults: Results of the U.S. Multicenter Phase III Clinical Trials (Safety). Journal Of Magnetic Resonance Imaging 2000, 12: 186-197. PMID: 10931579, DOI: 10.1002/1522-2586(200007)12:1<186::aid-jmri21>3.0.co;2-2.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal PainAdultAgedAged, 80 and overCardiovascular DiseasesContrast MediaDiagnosis, DifferentialEdetic AcidFemaleHumansImage EnhancementInjections, IntravenousLiver CirrhosisLiver NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedPainPregnancyPyridoxal PhosphateRisk AssessmentSensitivity and SpecificityVomitingConceptsMagnetic resonance imagingMangafodipir trisodium injectionAdverse eventsMulticenter phase III clinical trialContrast-enhanced computed tomography examinationPhase III clinical trialsUnenhanced magnetic resonance imagingInjection of MnDPDPInjection-associated discomfortSerious adverse eventsShort-term safetyHepatic magnetic resonance imagingComputed tomography examinationSignificant short-term riskShort-term riskFocal liver lesionsClinical trialsTomography examinationLaboratory valuesLiver lesionsResonance imagingVital signsPatientsMnDPDPInjectionHepatic MR Imaging with a Dynamic Contrast-enhanced Isotropic Volumetric Interpolated Breath-hold Examination: Feasibility, Reproducibility, and Technical Quality
Lee V, Lavelle M, Rofsky N, Laub G, Thomasson D, Krinsky G, Weinreb J. Hepatic MR Imaging with a Dynamic Contrast-enhanced Isotropic Volumetric Interpolated Breath-hold Examination: Feasibility, Reproducibility, and Technical Quality. Radiology 2000, 215: 365-72. PMID: 10796909, DOI: 10.1148/radiology.215.2.r00ma16365.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdultAgedAged, 80 and overCohort StudiesContrast MediaFeasibility StudiesFemaleFollow-Up StudiesGadolinium DTPAHepatic ArteryHepatic VeinsHumansImage EnhancementImage Processing, Computer-AssistedLiverLiver DiseasesMagnetic Resonance ImagingMaleMiddle AgedPortal VeinQuality ControlReproducibility of ResultsRespirationVena Cava, InferiorConceptsContrast materialMagnetic resonance imaging examinationsPatient underwent repeatVascular anatomic variantsDynamic contrastPortal venous phaseArterial dominanceUnderwent repeatVenous anatomyAnatomic variantsImaging examinationsTest bolusTest doseVenous phaseArterial phaseRepeat studyHepatic MRGadopentetate dimeglumineGradient-echo imagingTechnical qualityEnhanced acquisitionMaximal enhancementBreath-hold imagesOriginal studyAngiotensin-converting enzyme inhibitor-enhanced phase-contrast MR imaging to measure renal artery velocity waveforms in patients with suspected renovascular hypertension.
Lee V, Rofsky N, Ton A, Johnson G, Krinsky G, Weinreb J. Angiotensin-converting enzyme inhibitor-enhanced phase-contrast MR imaging to measure renal artery velocity waveforms in patients with suspected renovascular hypertension. American Journal Of Roentgenology 2000, 174: 499-508. PMID: 10658731, DOI: 10.2214/ajr.174.2.1740499.Peer-Reviewed Original Research
1999
A multisite phase III study of the safety and efficacy of a new manganese chloride‐based gastrointestinal contrast agent for MRI of the abdomen and pelvis
Small W, DeSimone‐Macchi D, Parker J, Sukerkar A, Hahn P, Rubin D, Zelch J, Kuhlman J, Outwater E, Weinreb J, Brown J, de Lange E, Woodward P, Arildsen R, Foster G, Runge V, Aisen A, Muroff L, Thoeni R, Parisky Y, Tanenbaum L, Totterman S, Herfkens R, Knudsen J, Laster R, Duerinckx A, Stillman A, Spritzer C, Saini S, Rofsky N, Bernardino M. A multisite phase III study of the safety and efficacy of a new manganese chloride‐based gastrointestinal contrast agent for MRI of the abdomen and pelvis. Journal Of Magnetic Resonance Imaging 1999, 10: 15-24. PMID: 10398973, DOI: 10.1002/(sici)1522-2586(199907)10:1<15::aid-jmri3>3.0.co;2-x.Peer-Reviewed Original ResearchConceptsGastrointestinal contrast agentAdverse eventsSite investigatorsGastrointestinal tract side effectsPatient diagnosisBlinded readersMore adverse eventsPhase III studyInflammatory bowel diseaseGroup of patientsPeptic ulcer diseaseML of placeboT2-weighted MRI scansMultisite clinical trialContrast agentsOral contrast agentAdditional diagnostic informationPlacebo patientsOral agentsIII studyBowel diseaseUlcer diseaseGastrointestinal pathologyLaboratory changesPhysical examinationSingle-Dose Breath-hold Gadolinium-enhanced Three-dimensional MR Angiography of the Renal Arteries
Lee V, Rofsky N, Krinsky G, Stemerman D, Weinreb J. Single-Dose Breath-hold Gadolinium-enhanced Three-dimensional MR Angiography of the Renal Arteries. Radiology 1999, 211: 69-78. PMID: 10189455, DOI: 10.1148/radiology.211.1.r99ap4869.Peer-Reviewed Original ResearchConceptsArterial enhancement ratioVenous enhancementRenal arteryTiming examinationContrast materialVascular enhancementMR angiographyBreath holdingContrast material administrationMagnetic resonance angiographyBreath-hold gadoliniumThree-dimensional magnetic resonance angiographyThree-dimensional MR angiographyRenal MR angiographyTest doseArterial enhancementResonance angiographyGadopentetate dimeglumineMaterial administrationAngiographyGradient-echo imagingEnhancement ratioSignificant differencesArteryAorta
1998
The effects of apnea on timing examinations for optimization of gadolinium-enhanced MRA of the thoracic aorta and arch vessels.
Krinsky G, Kaminer E, Lee V, Rofsky N, Weinreb J. The effects of apnea on timing examinations for optimization of gadolinium-enhanced MRA of the thoracic aorta and arch vessels. Journal Of Computer Assisted Tomography 1998, 22: 677-81. PMID: 9754096, DOI: 10.1097/00004728-199809000-00001.Peer-Reviewed Original ResearchConceptsEffects of apneaThoracic aortaGadolinium-enhanced 3D MR angiographyMR angiographyFree breathingArch vesselsTiming examinationGadolinium-enhanced MR angiographyProximal neckIndividual patientsArterial enhancementApneaBranch vesselsGadolinium contrast agentCirculation timePatientsVenous enhancementRespiratory patternLow dosesBreathingAortaAxial imagesMR angiogramsSignificant differencesExamination
1997
Peripheral vascular disease evaluated with reduced-dose gadolinium-enhanced MR angiography.
Rofsky N, Johnson G, Adelman M, Rosen R, Krinsky G, Weinreb J. Peripheral vascular disease evaluated with reduced-dose gadolinium-enhanced MR angiography. Radiology 1997, 205: 163-9. PMID: 9314979, DOI: 10.1148/radiology.205.1.9314979.Peer-Reviewed Original ResearchConceptsPeripheral vascular diseaseGadolinium-enhanced MR angiographyDigital subtraction angiographyVascular diseaseMR angiographyGadopentetate dimeglumineLower extremity peripheral vascular diseasePeripheral vascular areasExtent of diseaseMR angiography findingsGadolinium-enhanced magnetic resonance angiographyMagnetic resonance angiographyConventional digital subtraction angiographyStandard of referenceAngiography findingsMost patientsLess stenosisTreatment optionsLower extremitiesDSA findingsVascular areaAngiographyAnatomic segmentsAnatomic areasContrast materialGadolinium-enhanced body MR venography with subtraction technique.
Lebowitz J, Rofsky N, Krinsky G, Weinreb J. Gadolinium-enhanced body MR venography with subtraction technique. American Journal Of Roentgenology 1997, 169: 755-8. PMID: 9275892, DOI: 10.2214/ajr.169.3.9275892.Peer-Reviewed Original ResearchSuppression of venous signal in time-of-flight MR angiography of the lower extremities after administration of gadopentetate dimeglumine.
Rofsky N, Purdy D, Johnson G, DeCorato D, Earls J, Krinsky G, Weinreb J. Suppression of venous signal in time-of-flight MR angiography of the lower extremities after administration of gadopentetate dimeglumine. Radiology 1997, 202: 177-82. PMID: 8988209, DOI: 10.1148/radiology.202.1.8988209.Peer-Reviewed Original ResearchConceptsGadopentetate dimeglumineLower extremitiesMR angiographyPeripheral vascular diseaseVenous signalDistal lower extremityMR angiogramsGadopentetate dimeglumine administrationStudent's t-testFlight MR angiographyAdult patientsAngiography timeVascular diseaseFlight MR angiogramsGradient echo sequenceAdministrationDimegluminePatientsAngiographyT-testAngiogramsExtremitiesMuscle tissueVenous suppressionImaging sectionsThoracic aorta: comparison of gadolinium-enhanced three-dimensional MR angiography with conventional MR imaging.
Krinsky G, Rofsky N, DeCorato D, Weinreb J, Earls J, Flyer M, Galloway A, Colvin S. Thoracic aorta: comparison of gadolinium-enhanced three-dimensional MR angiography with conventional MR imaging. Radiology 1997, 202: 183-93. PMID: 8988210, DOI: 10.1148/radiology.202.1.8988210.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAorta, ThoracicAortic Aneurysm, ThoracicAortic CoarctationAortic DiseasesAortic DissectionContrast MediaDrug CombinationsFemaleGadoliniumGadolinium DTPAHumansImage Processing, Computer-AssistedInfant, NewbornMagnetic Resonance AngiographyMagnetic Resonance ImagingMaleMeglumineMiddle AgedOrganometallic CompoundsPentetic AcidRetrospective StudiesConceptsThoracic aortic diseaseThree-dimensional MR angiographyConventional MR imagingMR angiographyIntramural hematomaAortic dissectionAortic diseaseVessel diseaseMR imagingFindings of surgeryChronic aortic dissectionThoracic MR imagingComparison of gadoliniumMagnetic resonance angiographyThree-dimensional magnetic resonance angiographyDiagnosis of aneurysmConsecutive patientsAngiographyResonance angiographyMR examinationsGadopentetate dimeglumineReader B.DiseaseGradient echo sequenceConventional MR