P12.10.B HYPOKINETIC MOVEMENT DISORDERS FOLLOWING ADOPTIVE IMMUNOTHERAPY WITH BCMA-DIRECTED CAR T-CELLS: A CONSECUTIVE CASE SERIES
Gudera J, Baehring J, Fulbright R, Dietrich J, Karschnia P. P12.10.B HYPOKINETIC MOVEMENT DISORDERS FOLLOWING ADOPTIVE IMMUNOTHERAPY WITH BCMA-DIRECTED CAR T-CELLS: A CONSECUTIVE CASE SERIES. Neuro-Oncology 2024, 26: v68-v68. PMCID: PMC11485477, DOI: 10.1093/neuonc/noae144.223.Peer-Reviewed Original ResearchChimeric antigen receptorCAR-T cellsChimeric antigen receptor T cellsB-cell maturation antigenT cellsParkinsonism-like symptomsChimeric antigen receptor T-cell productsMovement disordersCirculating CAR T cellsHypokinetic movement disordersOn-target/off-tumor toxicityPatient died of sepsisCare of affected patientsRefractory multiple myelomaMedian follow-upConsecutive case seriesT cell productionDegree of suspicionBasal ganglia hypometabolismDiffusion-weighted sequencesMovement symptomsHead of the caudate nucleusAdoptive immunotherapyPatient diedSystemic immunosuppressionNeurological complications of medical therapies in haematological malignancies
Baehring J, Soussain C. Neurological complications of medical therapies in haematological malignancies. 2024, 109-122. DOI: 10.1093/med/9780198884903.003.0008.Peer-Reviewed Original ResearchChimeric antigen receptorStem cell transplantationHaematological malignanciesCell transplantationMedical therapyNeurological complicationsAssociated with posterior reversible encephalopathy syndromeAllogeneic stem cell transplantationGraft-versus-host diseasePosterior reversible encephalopathy syndromeRisk of opportunistic infectionsCerebrospinal fluidHaematopoietic stem cell transplantationCentral nervous system involvementComplications of medical therapySpectrum of neurological complicationsT-cell therapyGraft-versus-hostTumor lysis syndromeReversible encephalopathy syndromeDural sinus thrombosisNervous system involvementBispecific monoclonal antibodyAdaptive immune systemSpecific to patients