P12.10.B HYPOKINETIC MOVEMENT DISORDERS FOLLOWING ADOPTIVE IMMUNOTHERAPY WITH BCMA-DIRECTED CAR T-CELLS: A CONSECUTIVE CASE SERIES
Gudera J, Baehring J, Fulbright R, Dietrich J, Karschnia P. P12.10.B HYPOKINETIC MOVEMENT DISORDERS FOLLOWING ADOPTIVE IMMUNOTHERAPY WITH BCMA-DIRECTED CAR T-CELLS: A CONSECUTIVE CASE SERIES. Neuro-Oncology 2024, 26: v68-v68. PMCID: PMC11485477, DOI: 10.1093/neuonc/noae144.223.Peer-Reviewed Original ResearchChimeric antigen receptorCAR-T cellsChimeric antigen receptor T cellsB-cell maturation antigenT cellsParkinsonism-like symptomsChimeric antigen receptor T-cell productsMovement disordersCirculating CAR T cellsHypokinetic movement disordersOn-target/off-tumor toxicityPatient died of sepsisCare of affected patientsRefractory multiple myelomaMedian follow-upConsecutive case seriesT cell productionDegree of suspicionBasal ganglia hypometabolismDiffusion-weighted sequencesMovement symptomsHead of the caudate nucleusAdoptive immunotherapyPatient diedSystemic immunosuppressionParkinsonism Following Chimeric Antigen Receptor T Cell Therapy
Gudera J, Baehring J, Karschnia P. Parkinsonism Following Chimeric Antigen Receptor T Cell Therapy. JAMA Neurology 2024, 81 PMID: 39133506, DOI: 10.1001/jamaneurol.2024.2506.Peer-Reviewed Original Research