2001
Dynamic molecular modeling of pathogenic mutations in the spectrin self-association domain
Zhang Z, Weed S, Gallagher P, Morrow J. Dynamic molecular modeling of pathogenic mutations in the spectrin self-association domain. Blood 2001, 98: 1645-1653. PMID: 11535493, DOI: 10.1182/blood.v98.6.1645.Peer-Reviewed Original ResearchConceptsSelf-association domainPoint mutationsHuman sequenceDrosophila alpha-spectrinDynamic molecular modelingHuman erythrocyte spectrinCytoskeletal functionSpecific point mutationsConservative substitutionsPrimary sequenceConformational rearrangementsAlpha-spectrinHelical regionHydrophilic residuesAmino acidsMutationsSpectrinSalt bridgeErythrocyte spectrinStructural consequencesPathogenic mutationsRepeat unitsMolecular modelingSequenceStructural disruptionSpectrin Oligomerization is Cooperatively Coupled to Membrane Assembly: A Linkage Targeted by Many Hereditary Hemolytic Anemias?
Giorgi M, Cianci C, Gallagher P, Morrow J. Spectrin Oligomerization is Cooperatively Coupled to Membrane Assembly: A Linkage Targeted by Many Hereditary Hemolytic Anemias? Experimental And Molecular Pathology 2001, 70: 215-230. PMID: 11418000, DOI: 10.1006/exmp.2001.2377.Peer-Reviewed Original Research
1986
Abnormal spectrin in hereditary elliptocytosis.
Marchesi S, Knowles W, Morrow J, Bologna M, Marchesi V. Abnormal spectrin in hereditary elliptocytosis. Blood 1986, 67: 141-51. PMID: 3940543, DOI: 10.1182/blood.v67.1.141.bloodjournal671141.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnemia, Hemolytic, CongenitalElliptocytosis, HereditaryFemaleHumansMaleMiddle AgedPolymersSpectrinTrypsinConceptsClinical expressionHemolytic anemiaSubset of patientsRare hemolytic anemiaAlpha iAlpha II domainAlpha subunitHereditary pyropoikilocytosisFunctional resultsSpectrin alpha subunitHereditary elliptocytosisHematologic diseasesAnemiaMild elliptocytosisAbnormal spectrinSeverityPresent studyKD peptideExpressionD-peptidesFrequent occurrenceSpectrin self-association