2023
A generalizable new figure of merit for dose optimization in dual energy cone beam CT scanning protocols
Li C, Zhou L, Deng J, Wu H, Wang R, Wang F, Yao K, Chen C, Niu T, Zhang Y. A generalizable new figure of merit for dose optimization in dual energy cone beam CT scanning protocols. Physics In Medicine And Biology 2023, 68: 185021. PMID: 37619587, DOI: 10.1088/1361-6560/acf3cd.Peer-Reviewed Original ResearchLiver cancer risk quantification through an artificial neural network based on personal health data
Ataei A, Deng J, Muhammad W. Liver cancer risk quantification through an artificial neural network based on personal health data. Acta Oncologica 2023, 62: 495-502. PMID: 37211681, DOI: 10.1080/0284186x.2023.2213445.Peer-Reviewed Original ResearchConceptsNational Health Interview SurveyLiver cancer riskHealth dataCancer riskHealth Interview SurveyHepatocellular carcinomaPersonal health dataHigh-risk populationLiver cancerInterview SurveyReceiver operating characteristic curveArea under the receiver operating characteristic curveCancer-related deathsPrimary liver cancerHealthOvarian cancerTherapeutic optionsMalignant diseaseTest cohortEarly detectionAggressive progressionRiskCancerCharacteristic curveLiverLong-term survival and second malignant tumor prediction in pediatric, adolescent, and young adult cancer survivors using Random Survival Forests: a SEER analysis
Zhang I, Hart G, Qin B, Deng J. Long-term survival and second malignant tumor prediction in pediatric, adolescent, and young adult cancer survivors using Random Survival Forests: a SEER analysis. Scientific Reports 2023, 13: 1911. PMID: 36732358, PMCID: PMC9894907, DOI: 10.1038/s41598-023-29167-x.Peer-Reviewed Original ResearchConceptsYoung adult cancer survivorsAdult cancer survivorsRandom survival forestCancer survivorsFirst diagnosisFirst tumor diagnosisHigh-risk individualsProportional hazards modelAverage C-indexU.S. Surveillance EpidemiologyLong-term survivalTime-dependent areaTime-dependent AUCPotential clinical valueSurvival analysis studyMalignancy prediction modelSurvival forestsSEER analysisSecond malignanciesSurveillance EpidemiologySecond tumorC-indexConcordance indexClinical valuePhysician burden
2020
Impact of radiation source activity on short- and long-term outcomes of cervical carcinoma patients treated with high-dose-rate brachytherapy: A retrospective cohort study
Li C, Li X, You J, Liang B, Su X, Huang Y, Chen Y, Hu Q, Deng J, Wang H, Pu Y, Liu H, Ma Y, Wang W, Wu H, Zhang Y. Impact of radiation source activity on short- and long-term outcomes of cervical carcinoma patients treated with high-dose-rate brachytherapy: A retrospective cohort study. Gynecologic Oncology 2020, 159: 365-372. PMID: 32933759, DOI: 10.1016/j.ygyno.2020.08.037.Peer-Reviewed Original ResearchConceptsMetastatic recurrence-free survivalLocal recurrence-free survivalCervical carcinoma patientsRecurrence-free survivalLong-term outcomesCarcinoma patientsPatient outcomesRetrospective cohort studyShort-term outcomesMedian followCohort studyIridium-192 sourceSubgroup analysisSurvival timeRate brachytherapyStage IDay 199PatientsPractice patterns and recommendations for pediatric image‐guided radiotherapy: A Children's Oncology Group report
Hua C, Vern‐Gross T, Hess CB, Olch AJ, Alaei P, Sathiaseelan V, Deng J, Ulin K, Laurie F, Gopalakrishnan M, Esiashvili N, Wolden SL, Krasin MJ, Merchant TE, Donaldson SS, FitzGerald TJ, Constine LS, Hodgson DC, Haas‐Kogan D, Mahajan A, Laack NN, Marcus KJ, Taylor PA, Ahern VA, Followill DS, Buchsbaum JC, Breneman JC, Kalapurakal JA. Practice patterns and recommendations for pediatric image‐guided radiotherapy: A Children's Oncology Group report. Pediatric Blood & Cancer 2020, 67: e28629. PMID: 32776500, PMCID: PMC7774502, DOI: 10.1002/pbc.28629.Peer-Reviewed Original ResearchConceptsChildren's Oncology GroupImage-guided radiotherapyOncology GroupPractice patternsOncology disciplinesChildren's Oncology Group reportPaediatric radiotherapy patientsTreatment modalitiesExpert guidelinesDose reductionRadiotherapy patientsPractice recommendationsSetup correctionAdaptive therapyRadiotherapyImage guidanceReportMember surveyGroup ReportPatientsTherapyClinicians
2019
Predicting breast cancer risk using personal health data and machine learning models
Stark GF, Hart GR, Nartowt BJ, Deng J. Predicting breast cancer risk using personal health data and machine learning models. PLOS ONE 2019, 14: e0226765. PMID: 31881042, PMCID: PMC6934281, DOI: 10.1371/journal.pone.0226765.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast cancer risk predictionCancer riskCancer risk predictionGail modelBreast cancer risk prediction toolsCancer risk prediction toolsPositive breast cancer casesHormone replacement therapyRisk stratification toolRisk predictionRisk prediction toolsHealth dataBreast cancer casesPersonal health dataStratification toolReplacement therapyLeading causeBreast cancerCancer casesInvasive proceduresBCRATDeLong testLogistic regressionEarly breast cancer detectionScoring colorectal cancer risk with an artificial neural network based on self-reportable personal health data
Nartowt BJ, Hart GR, Roffman DA, Llor X, Ali I, Muhammad W, Liang Y, Deng J. Scoring colorectal cancer risk with an artificial neural network based on self-reportable personal health data. PLOS ONE 2019, 14: e0221421. PMID: 31437221, PMCID: PMC6705772, DOI: 10.1371/journal.pone.0221421.Peer-Reviewed Original ResearchConceptsNational Health Interview SurveyUnited States Preventative Services Task ForceColorectal cancerPredictive valueDiagnosis of CRCColorectal cancer riskHealth Interview SurveyHigh-risk categoryNegative predictive valuePositive predictive valueMultivariable prediction modelHealth dataUSPSTF guidelinesRisk score methodCRC riskFamily historyCancer riskHigh riskAge 50Individual prognosisLower riskPersonal health dataClinical applicabilityInterview SurveyCancer
2018
Development and Validation of a Multiparameterized Artificial Neural Network for Prostate Cancer Risk Prediction and Stratification
Roffman DA, Hart GR, Leapman MS, Yu JB, Guo FL, Ali I, Deng J. Development and Validation of a Multiparameterized Artificial Neural Network for Prostate Cancer Risk Prediction and Stratification. JCO Clinical Cancer Informatics 2018, 2: 1-10. PMID: 30652591, PMCID: PMC6873987, DOI: 10.1200/cci.17.00119.Peer-Reviewed Original ResearchConceptsProstate Cancer Risk PredictionCancer risk predictionPositive predictive valueProstate cancerRisk predictionPredictive valueHistory of strokeHigh-risk subgroupsBody mass indexCancer risk stratificationHealth informationPersonal health informationPrimary prostate cancerYears of ageDiabetes statusRisk stratificationSmoking statusMass indexCancer populationHeart diseaseExercise habitsCancer riskHigh riskCutoff valueAdult survey dataA multi-parameterized artificial neural network for lung cancer risk prediction
Hart GR, Roffman DA, Decker R, Deng J. A multi-parameterized artificial neural network for lung cancer risk prediction. PLOS ONE 2018, 13: e0205264. PMID: 30356283, PMCID: PMC6200229, DOI: 10.1371/journal.pone.0205264.Peer-Reviewed Original ResearchConceptsLung cancer risk predictionHistory of strokeNon-invasive clinical toolLung cancer riskHealth informationPersonal health informationNon-cancer casesCancer risk predictionRisk stratificationSmoking statusHeart diseaseExercise habitsHispanic ethnicityLung cancer detectionCancer riskClinical toolAdult dataRisk predictionModest sensitivityCancer detectionAUCHigh specificitySpecificityHypertensionAsthmaImaging Dose, Cancer Risk and Cost Analysis in Image-guided Radiotherapy of Cancers
Zhou L, Bai S, Zhang Y, Ming X, Zhang Y, Deng J. Imaging Dose, Cancer Risk and Cost Analysis in Image-guided Radiotherapy of Cancers. Scientific Reports 2018, 8: 10076. PMID: 29973695, PMCID: PMC6031630, DOI: 10.1038/s41598-018-28431-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBone Marrow CellsBrainChildChild, PreschoolCone-Beam Computed TomographyCost-Benefit AnalysisFemaleHumansInfantLungMaleMiddle AgedMonte Carlo MethodNeoplasmsPhantoms, ImagingRadiation DosageRadiotherapy DosageRadiotherapy, Image-GuidedRisk FactorsThoraxYoung AdultConceptsCancer riskAssociated cancer riskImage-guided radiotherapyImaging proceduresLifetime attributable riskImaging dosesAverage lifetime attributable riskRadiological imaging proceduresRed bone marrowRetrospective studyCancer patientsLung cancerAttributable riskCancer incidenceBilling codesIndividual patientsBone marrowBrain cancerImage guidance proceduresPelvic scanPatientsCancerOrgan dosesRadiotherapyDosesPredicting non-melanoma skin cancer via a multi-parameterized artificial neural network
Roffman D, Hart G, Girardi M, Ko CJ, Deng J. Predicting non-melanoma skin cancer via a multi-parameterized artificial neural network. Scientific Reports 2018, 8: 1701. PMID: 29374196, PMCID: PMC5786038, DOI: 10.1038/s41598-018-19907-9.Peer-Reviewed Original ResearchConceptsNon-melanoma skin cancerFamily historySkin cancerUVR exposureHistory of strokePotential predictive parametersNon-cancer casesFamily history informationUltraviolet radiation exposureDiabetic statusSmoking statusHeart diseaseRisk factorsExercise habitsHispanic ethnicityPredictive parametersAdult survey dataEarly detectionRadiation exposureROC curveHealth informationPersonal health informationNovel associationsCancerExposure
2017
Personalized and Conscientious Medical Imaging: To Image or Not to Image
Deng J. Personalized and Conscientious Medical Imaging: To Image or Not to Image. JAMA Oncology 2017, 3: 443-444. PMID: 27466980, PMCID: PMC5857946, DOI: 10.1001/jamaoncol.2016.2220.Peer-Reviewed Original ResearchAdvances in the Decision to Image or Not to Image—Reply
Deng J, Kim JJ. Advances in the Decision to Image or Not to Image—Reply. JAMA Oncology 2017, 3: 565. PMID: 27930759, PMCID: PMC5858581, DOI: 10.1001/jamaoncol.2016.4849.Peer-Reviewed Original ResearchA measurement-based generalized source model for Monte Carlo dose simulations of CT scans
Ming X, Feng Y, Liu R, Yang C, Zhou L, Zhai H, Deng J. A measurement-based generalized source model for Monte Carlo dose simulations of CT scans. Physics In Medicine And Biology 2017, 62: 1759-1776. PMID: 28079526, PMCID: PMC5857954, DOI: 10.1088/1361-6560/aa5911.Peer-Reviewed Original ResearchConceptsMonte Carlo dose simulationsGeneralized source modelEnergy spectrumFluence distributionDose profilesCentral axis percent depth dose curvePercent depth dose curvesDose simulationsDepth dose curvesMonte Carlo user codeSource distributionBeam inputDose curvesFilm measurementsCTDI phantomCT scannerOutput factorsAbsolute dose comparisonsMonte Carlo simulationsDose distributionSource modelCarlo simulationsCircular sourceGE LightspeedScanner specifications
2016
Radiation-induced heart disease in lung cancer radiotherapy
Ming X, Feng Y, Yang C, Wang W, Wang P, Deng J. Radiation-induced heart disease in lung cancer radiotherapy. Medicine 2016, 95: e5051. PMID: 27741117, PMCID: PMC5072944, DOI: 10.1097/md.0000000000005051.Peer-Reviewed Original ResearchConceptsRadiation-induced heart diseaseLung cancer radiotherapyLung cancer patientsPotential risk factorsCancer radiotherapyCancer patientsCardiac toxicityHeart diseaseRisk factorsRadiation treatmentLung cancer survivorsLate side effectsHistory of heartTypes of cancerCardiac complicationsCrude incidencePulmonary diseaseBetter prognosisLobar locationBenign diseaseCancer survivorsLung cancerTreatment modalitiesPatient prognosisBreast cancerNovel Technologies for Improved Treatment Outcome and Patient Safety in Cancer Radiotherapy
Deng J, Feng Y, Ma C, Yin FF. Novel Technologies for Improved Treatment Outcome and Patient Safety in Cancer Radiotherapy. BioMed Research International 2016, 2016: 3016454. PMID: 27034929, PMCID: PMC4791494, DOI: 10.1155/2016/3016454.Peer-Reviewed Original ResearchEnergy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study
Zhang Y, Feng Y, Ming X, Deng J. Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study. BioMed Research International 2016, 2016: 7319843. PMID: 26977413, PMCID: PMC4763028, DOI: 10.1155/2016/7319843.Peer-Reviewed Original ResearchConceptsIMRT plansPediatric brain tumorsNovel treatment modalitiesNormal tissue sparingDifferent tumor sitesDosimetric gainLung cancerTreatment modalitiesIndividual patientsBrain tumorsTissue sparingIMRT techniqueTumor sitePersonalized carePhoton radiotherapyThyroid lesionsDose distributionIntegral doseRadiotherapy treatmentInverse planning systemPatientsRadiotherapyFeasibility studyModern radiotherapy treatmentsClinical IMRT plans
2015
Intermediate Megavoltage Photon Beams for Improved Lung Cancer Treatments
Zhang Y, Feng Y, Ahmad M, Ming X, Zhou L, Deng J. Intermediate Megavoltage Photon Beams for Improved Lung Cancer Treatments. PLOS ONE 2015, 10: e0145117. PMID: 26672752, PMCID: PMC4682946, DOI: 10.1371/journal.pone.0145117.Peer-Reviewed Original ResearchConceptsDosimetric benefitsPotential dosimetric benefitsTarget coverageComparable target coverageLung cancer patientsLung cancer treatmentBetter target coverageCurrent treatment approachesImproved tumor coverageNormal tissue dosesTumor dose coverageLung cancer radiotherapyAdjacent critical structuresCritical structuresLung doseCancer patientsLung cancerThin patientsLung volumeLung tumorsDose coverageTreatment approachesPatientsReduced dosesTumor coverageCardiac Exposure in the Dynamic Conformal Arc Therapy, Intensity-Modulated Radiotherapy and Volumetric Modulated Arc Therapy of Lung Cancer
Ming X, Feng Y, Liu H, Zhang Y, Zhou L, Deng J. Cardiac Exposure in the Dynamic Conformal Arc Therapy, Intensity-Modulated Radiotherapy and Volumetric Modulated Arc Therapy of Lung Cancer. PLOS ONE 2015, 10: e0144211. PMID: 26630566, PMCID: PMC4667972, DOI: 10.1371/journal.pone.0144211.Peer-Reviewed Original ResearchConceptsDynamic conformal arc therapyLung cancer patientsIntensity-modulated radiotherapyIrradiated heart volumeCardiac exposureHeart distanceConformal arc therapyCancer patientsHeart volumeArc therapyHeart doseCardiac diseaseLong-term cardiac toxicityMean heart doseMean heart dosesRight lung tumorLung cancer treatmentVolumetric Modulated Arc TherapyRadiotherapy treatment modalitiesInstitutional review boardLung cancer radiotherapyHeart dosesHeart sparingCardiac complicationsHodgkin's diseaseIn Reply to Wang et al
Zhang Y, Feng Y, Zhang Y, Ming X, Yu J, Carlson D, Kim J, Deng J. In Reply to Wang et al. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: 211-213. PMID: 26279038, DOI: 10.1016/j.ijrobp.2015.04.010.Peer-Reviewed Original Research