1999
Global variation of a 40-bp VNTR in the 3′-untranslated region of the dopamine transporter gene (SLC6A3)
Kang A, Palmatier M, Kidd K. Global variation of a 40-bp VNTR in the 3′-untranslated region of the dopamine transporter gene (SLC6A3). Biological Psychiatry 1999, 46: 151-160. PMID: 10418689, DOI: 10.1016/s0006-3223(99)00101-8.Peer-Reviewed Original Research
1997
Homozygosity by descent for a rare mutation in the myophosphorylase gene is associated with variable phenotypes in a Druze family with McArdle disease.
Iyengar S, Kalinsky H, Weiss S, Korostishevsky M, Sadeh M, Zhao Y, Kidd K, Bonne-Tamir B. Homozygosity by descent for a rare mutation in the myophosphorylase gene is associated with variable phenotypes in a Druze family with McArdle disease. Journal Of Medical Genetics 1997, 34: 391. PMID: 9152836, PMCID: PMC1050946, DOI: 10.1136/jmg.34.5.391.Peer-Reviewed Original Research
1995
Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with tourette syndrome
Gelernter J, Rao P, Pauls D, Hamblin M, Sibley D, Kidd K. Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with tourette syndrome. Genomics 1995, 26: 207-209. PMID: 7601444, DOI: 10.1016/0888-7543(95)80202-w.Peer-Reviewed Original ResearchConceptsGenetic linkageSomatic cell hybridsInteresting candidate genesPairwise linkage analysisCell hybridsNovel serotonin receptorCandidate genesChromosome 10Linkage analysisSouthern blotGenesExtended pedigreesLOD scoreReceptor geneLociGenetic polymorphismsHTR7PolymorphismReceptorsLIPED computer programDNALinkageHybridizationNeuropsychiatric disordersPedigree
1993
A hypervariable segment in the human dopamine receptor D4 (DRD4) gene
Lichter J, Barr C, Kennedy J, Van Tol H, Kidd K, Livak K. A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Human Molecular Genetics 1993, 2: 767-773. PMID: 8353495, DOI: 10.1093/hmg/2.6.767.Peer-Reviewed Original ResearchConceptsHuman dopamine receptor D4 geneAmino acid sequenceThird cytoplasmic loopNumber of repeatsPutative third cytoplasmic loopFunctional proteinsCytoplasmic loopAcid sequenceRepeat regionDifferent repeatsHypervariable segmentDifferent haplotypesRepeatsDopamine receptor D4 geneUnrelated chromosomesNovel polymorphismsD4 geneGenesProteinHuman dopamine D4 receptorPolymorphic variantsSequencePolymorphismChromosomesReceptors
1991
Coupled amplification and sequencing of genomic DNA.
Ruano G, Kidd K. Coupled amplification and sequencing of genomic DNA. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 2815-2819. PMID: 1672768, PMCID: PMC51330, DOI: 10.1073/pnas.88.7.2815.Peer-Reviewed Original ResearchDrift, admixture, and selection in human evolution: a study with DNA polymorphisms.
Bowcock A, Kidd J, Mountain J, Hebert J, Carotenuto L, Kidd K, Cavalli-Sforza L. Drift, admixture, and selection in human evolution: a study with DNA polymorphisms. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 839-843. PMID: 1992475, PMCID: PMC50909, DOI: 10.1073/pnas.88.3.839.Peer-Reviewed Original ResearchConceptsDNA polymorphismsEqual evolutionary ratesRandom genetic driftEvolutionary ratesGenetic driftEvolutionary analysisNatural selectionGenetic markersHuman evolutionGene frequenciesEarly admixtureHuman differentiationEvolutionary modelsPolymorphismHigh variationLow variationGenetic polymorphismsMeasures of variationGenesPopulationSpeciesObserved distributionDifferentiationVariationSelection
1990
Report of the DNA committee and catalogues of cloned and mapped genes and DNA polymorphisms (Part 1 of 14)
Williamson R, Bowcock A, Kidd K, Pearson P, Schmidtke J, Chan H, Chipperfield M, Cooper D, Hewitt J, Lewitter F, Maidak B, Quitt M, Ricciuti F, Track R, Tolley M, Trumper S, Walley A. Report of the DNA committee and catalogues of cloned and mapped genes and DNA polymorphisms (Part 1 of 14). Cytogenetic And Genome Research 1990, 55: 457-472. PMID: 2073845, DOI: 10.1159/000133027.Peer-Reviewed Original Research
1989
Direct haplotyping of chromosomal segments from multiple heterozygotes via allele-specific PCR amplification
Ruano G, Kidd K. Direct haplotyping of chromosomal segments from multiple heterozygotes via allele-specific PCR amplification. Nucleic Acids Research 1989, 17: 8392-8392. PMID: 2573038, PMCID: PMC334997, DOI: 10.1093/nar/17.20.8392.Peer-Reviewed Original Research
1988
The human “interferon-β2/hepatocyte stimulating factor/interleukin-6” gene: DNA polymorphism studies and localization to chromosome 7p21
Bowcock A, Kidd J, Lathrop G, Daneshvar L, May L, Ray A, Sehgal P, Kidd K, Cavalli-Sforza L. The human “interferon-β2/hepatocyte stimulating factor/interleukin-6” gene: DNA polymorphism studies and localization to chromosome 7p21. Genomics 1988, 3: 8-16. PMID: 2906047, DOI: 10.1016/0888-7543(88)90152-8.Peer-Reviewed Original ResearchConceptsHybridoma growth factorChromosome 7 markersPolymorphic MspI siteDNA polymorphism studiesBase pair substitutionsDNA replicationDNA insertionFifth exonGene productsProtein responseEnzyme MspIAT dinucleotidesVariety of haplotypesBglI polymorphismFactor/interleukinGenesLinkage disequilibriumMspI sitePolymorphic sitesPair substitutionsMspILinkage studiesFactor 2Polymorphism studiesKbTyrosine hydroxylase maps to the short arm of chromosome 11 proximal to the insulin and HRAS1 loci
Xue F, Kidd J, Pakstis A, Castiglione C, Mallet J, Kidd K. Tyrosine hydroxylase maps to the short arm of chromosome 11 proximal to the insulin and HRAS1 loci. Genomics 1988, 2: 288-293. PMID: 2906039, DOI: 10.1016/0888-7543(88)90016-x.Peer-Reviewed Original ResearchAn MPO cDNA clone identifies an RFLP with PstI
Miki T, Weil S, Rosner G, Reid M, Kidd K. An MPO cDNA clone identifies an RFLP with PstI. Nucleic Acids Research 1988, 16: 1649-1649. PMID: 2894639, PMCID: PMC336369, DOI: 10.1093/nar/16.4.1649.Peer-Reviewed Original ResearchMolecular genetics of an autosomal dominant form of torsion dystonia.
Kramer P, Ozelius L, Brin M, Fahn S, Kidd K, Gusella J, Breakefield X. Molecular genetics of an autosomal dominant form of torsion dystonia. Advances In Neurology 1988, 50: 57-66. PMID: 2899954.Peer-Reviewed Original Research
1987
Early Onset (Under Age 30 Years) and Panic Disorder as Markers for Etiologic Homogeneity in Major Depression
Price R, Kidd K, Weissman M. Early Onset (Under Age 30 Years) and Panic Disorder as Markers for Etiologic Homogeneity in Major Depression. JAMA Psychiatry 1987, 44: 434-440. PMID: 3472494, DOI: 10.1001/archpsyc.1987.01800170048008.Peer-Reviewed Original ResearchConceptsEarly onsetMajor depressionPanic disorderLate-onset depressionPrevalence of depressionElevation of riskFamilies of probandsYale Family StudyEtiologic homogeneityHigh riskPatterns of transmissionOlder age cohortsRestriction of analysisDepressionPopulation ratesFamily studiesProbandsOnsetDisordersAge cohortsRiskGenetic modelsSample sizeCohortPrevalenceSearching for Major Genes for Psychiatric Disorders
Kidd K. Searching for Major Genes for Psychiatric Disorders. Novartis Foundation Symposia 1987, 130: 184-196. PMID: 2894929, DOI: 10.1002/9780470513507.ch11.Peer-Reviewed Original ResearchConceptsPsychiatric disordersManic-depressive illnessMajor psychiatric disordersGenetic linkage studiesDepressive illnessAetiological factorsLinkage studiesNeurochemical complexityCommon disorderBiochemical abnormalitiesFamilial clusteringMajor genetic componentGenetic factorsDisordersRestriction fragment length polymorphismReasonable evidenceFragment length polymorphismLength polymorphismGenetic componentEvidenceCandidate genesIllnessAbnormalitiesSuspicionBrain
1986
DNA polymorphisms for the nerve growth factor receptor gene exclude its role in familial dysautonomia.
Breakefield X, Ozelius L, Bothwell M, Chao M, Axelrod F, Kramer P, Kidd K, Lanahan A, Johnson D, Ross A. DNA polymorphisms for the nerve growth factor receptor gene exclude its role in familial dysautonomia. Molecular Biology & Medicine 1986, 3: 483-94. PMID: 2886891.Peer-Reviewed Original ResearchConceptsNerve growth factor receptor geneGrowth factor receptor geneFactor receptor geneReceptor geneExcellent genetic markerAshkenazic Jewish populationPolymorphic restriction sitesDNA polymorphismsFamilial dysautonomiaGenetic markersBeta subunitLinkage analysisGenesRestriction sitesChromosome 17qAutosomal recessive modeAllelesPossible roleRecessive modeAffected individualsNeuronal factorsPolymorphismNGF actionCentimorgansMore membersLinkage Analysis in a Family with Dominantly Inherited Torsion Dystonia: Exclusion of the Pro-Opiomelanocortin and Glutamic Acid Decarboxylase Genes and Other Chromosomal Regions Using DNA Polymorphisms
Breakefield X, Bressman S, Kramer P, Ozelius L, Moskowitz C, Tanzi R, Brin M, Hobbs W, Kaufman D, Tobin A, Kidd K, Fahn S, Gusella J. Linkage Analysis in a Family with Dominantly Inherited Torsion Dystonia: Exclusion of the Pro-Opiomelanocortin and Glutamic Acid Decarboxylase Genes and Other Chromosomal Regions Using DNA Polymorphisms. Journal Of Neurogenetics 1986, 3: 159-175. PMID: 3016220, DOI: 10.3109/01677068609106846.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedChildChild, PreschoolChromosome DeletionChromosome MappingCloning, MolecularDNADNA Restriction EnzymesDystonia Musculorum DeformansFemaleGenesGenes, DominantGenetic LinkageGlutamate DecarboxylaseHumansLymphocytesMaleMiddle AgedPedigreePolymorphism, GeneticPro-OpiomelanocortinConceptsLinkage analysisGlutamic acid decarboxylase geneRestriction fragment length polymorphismDecarboxylase geneDNA sequencesMode of inheritanceChromosomal regionsDNA polymorphismsFragment length polymorphismDefective geneLod score methodGenesDNA probesLength polymorphismLymphoblast linesInheritanceDisease statesAutosomal dominant modeGene penetranceSequenceFamilyPolymorphismGenomeAcid decarboxylaseRequisite assumptions
1985
Linkage relationships of the gene for the β subunit of nerve growth factor (NGFB) with other chromosome 1 marker loci
Darby J, Kidd J, Pakstis A, Sparkes R, Cann H, Ferrell R, Gerhard D, Riccardi V, Egeland J, Shooter E, Cavalli-Sforza L, Kidd K. Linkage relationships of the gene for the β subunit of nerve growth factor (NGFB) with other chromosome 1 marker loci. Cytogenetic And Genome Research 1985, 39: 158-160. PMID: 4006521, DOI: 10.1159/000132127.Peer-Reviewed Original Research
1984
Identification of a recent recombination event within the human beta-globin gene cluster.
Gerhard D, Kidd K, Kidd J, Egeland J, Housman D. Identification of a recent recombination event within the human beta-globin gene cluster. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 7875-7879. PMID: 6096866, PMCID: PMC392255, DOI: 10.1073/pnas.81.24.7875.Peer-Reviewed Original ResearchConceptsBeta-globin gene clusterHuman beta-globin gene clusterGene clusterRecombination eventsChromosome 11DNA sequence polymorphismsRecent recombination eventsGenetic recombination eventsMeiotic crossingDNA regionsDNA markersC-Ha-rasSequence polymorphismsReference pedigreesCrossover eventsOncogene c-Ha-rasPreproparathyroid hormoneSegment 12PedigreeD11S12HaplotypesInheritanceClustersRegionHot spots
1980
Alternative genetic models for the analysis of complex traits.
Kidd K, Gladstien K. Alternative genetic models for the analysis of complex traits. Progress In Clinical And Biological Research 1980, 46: 407-35. PMID: 7022462.Peer-Reviewed Original Research
1978
Research Designs for the Study of Gene-Environment Interactions in Psychiatric Disorders: Report of a Foundations Fund for Research in Psychiatry Panel
Kidd K, Matthysee S. Research Designs for the Study of Gene-Environment Interactions in Psychiatric Disorders: Report of a Foundations Fund for Research in Psychiatry Panel. JAMA Psychiatry 1978, 35: 925-932. PMID: 678045, DOI: 10.1001/archpsyc.1978.01770320019001.Peer-Reviewed Original ResearchConceptsGenetic variantsUnrelated individualsIndividual genetic variantsGenetic variationDifferent genetic variantsExtended pedigreesGenetic heterogeneityGene-environment interactionsGenetic hypothesisPhenotypeDiagnostic phenotypesFamilyGeneticsVariantsTraitsIndividual susceptibilitySpecific hypothesesSuch studiesHypothesisEnvironmental contributionsPedigreeGenotypesSusceptibility