Degradation Signal Masking by Heterodimerization of MATα2 and MATa1 Blocks Their Mutual Destruction by the Ubiquitin-Proteasome Pathway
Johnson P, Swanson R, Rakhilina L, Hochstrasser M. Degradation Signal Masking by Heterodimerization of MATα2 and MATa1 Blocks Their Mutual Destruction by the Ubiquitin-Proteasome Pathway. Cell 1998, 94: 217-227. PMID: 9695950, DOI: 10.1016/s0092-8674(00)81421-x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceCysteine EndopeptidasesDimerizationDiploidyFungal ProteinsHaploidyIntramolecular TransferasesLipoproteinsMating FactorMolecular Sequence DataMultienzyme ComplexesMutationPeptidesPheromonesProteasome Endopeptidase ComplexProtein Structure, SecondarySaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsUbiquitinsConceptsUbiquitin-proteasome pathwayDegradation signalCoiled-coil interactionsAlpha haploid cellsRegulated turnoverMultiprotein complexesHaploid cellsPathway substrateTranscription factorsExtensive mutagenesisProteolytic signalMolecular mechanismsCell typesHeterodimerizationSuch regulationCritical determinantPathwayAlpha2MATa1MATα2Signal maskingRepressorHaploidsSaccharomycesMutagenesisUbiquitin-Dependent Degradation of Transcription Regulators
Hochstrasser M, Kornitzer D. Ubiquitin-Dependent Degradation of Transcription Regulators. 1998, 279-302. DOI: 10.1007/978-1-4899-1922-9_9.Peer-Reviewed Original ResearchTranscription factorsTranscription regulatorsBacterial transcription factorsYeast transcription factorUbiquitin-dependent degradationUbiquitin-proteasome pathwayActivity of proteinsTranscription factor c-FosMain regulatory proteinTranscription initiationCellular proteinsRegulatory proteinsC-MycProteinMost cellsRegulatorIntracellular levelsExamples of degradationC-fosRapid modulationPathwayNumerous levelsEukaryotesMATα2Σ32