2024
Controversy in mechanotransduction – the role of endothelial cell–cell junctions in fluid shear stress sensing
X S, Aitken C, Mehta V, Tardajos-Ayllon B, Serbanovic-Canic J, Zhu J, Miao B, Tzima E, Evans P, Fang Y, Schwartz M. Controversy in mechanotransduction – the role of endothelial cell–cell junctions in fluid shear stress sensing. Journal Of Cell Science 2024, 137: jcs262348. PMID: 39143856, PMCID: PMC11423816, DOI: 10.1242/jcs.262348.Peer-Reviewed Original ResearchShear stress sensingFluid shear stressFluid flowCell-cell contactShear stressCell-cell adhesionStress sensingCell-cell junctionsEndothelial cell-cell junctionsEC alignmentRegulates vascular developmentAdhesion receptorsCell typesEndothelial cellsFlowSingle cellsVascular developmentShearAdhesionContact
2007
Induction of Vascular Permeability: βPIX and GIT1 Scaffold the Activation of Extracellular Signal-regulated Kinase by PAK
Stockton R, Reutershan J, Scott D, Sanders J, Ley K, Schwartz MA. Induction of Vascular Permeability: βPIX and GIT1 Scaffold the Activation of Extracellular Signal-regulated Kinase by PAK. Molecular Biology Of The Cell 2007, 18: 2346-2355. PMID: 17429073, PMCID: PMC1877103, DOI: 10.1091/mbc.e06-07-0584.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCapillary PermeabilityCattleCell Cycle ProteinsCells, CulturedEndothelial CellsEnzyme ActivationExtracellular Signal-Regulated MAP KinasesGuanine Nucleotide Exchange FactorsHumansInflammationLipopolysaccharidesLungMiceP21-Activated KinasesPeptidesProtein Serine-Threonine KinasesRho Guanine Nucleotide Exchange FactorsConceptsP21-activated kinaseMitogen-activated protein kinase kinaseEndothelial cell-cell junctionsExtracellular signal-regulated kinaseCell-cell junctionsProtein kinase kinaseMyosin light chain phosphorylationLight chain phosphorylationSignal-regulated kinaseCell-permeant peptideActivation of ERKKinase kinaseExtracellular signalsPAK functionChain phosphorylationCritical regulatorKinaseCell contractilityCell typesCultured endothelial cellsPhosphorylationMouse lung injury modelMyosin phosphorylationEndothelial cellsGIT1
2003
Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl
Truong T, Sun G, Doorly M, Wang JY, Schwartz MA. Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 10281-10286. PMID: 12928501, PMCID: PMC193552, DOI: 10.1073/pnas.1635435100.Peer-Reviewed Original ResearchConceptsC-Abl/p73 pathwayDNA damageIntegrin ligationC-AblDNA damage-induced apoptosisC-Abl tyrosine kinaseCell adhesionExtracellular matrixDamage-induced apoptosisP73 pathwayCertain cell typesP53-negative tumor cellsProapoptotic transcription factorTranscription factorsTyrosine kinaseApoptotic responseDifferential utilizationCell typesDifferent tumor cell linesTumor cell linesTumor cellsP53 levelsCell linesSecond pathwayCell killing
2002
Integrins regulate the apoptotic response to DNA damage through modulation of p53
Lewis JM, Truong TN, Schwartz MA. Integrins regulate the apoptotic response to DNA damage through modulation of p53. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 3627-3632. PMID: 11904424, PMCID: PMC122574, DOI: 10.1073/pnas.062698499.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesApoptosisCaspase 3CaspasesCell AdhesionCell SurvivalChromosome AberrationsCyclin-Dependent Kinase Inhibitor p16DNA DamageFibroblastsHumansIntegrinsMelanomaMiceMutationNuclear ProteinsOrgan SpecificityProto-Oncogene ProteinsProto-Oncogene Proteins c-mdm2Radiation, IonizingSarcomaTumor Cells, CulturedTumor Suppressor Protein p14ARFTumor Suppressor Protein p53ConceptsTumor cellsTherapy-resistant tumorsModulation of p53Susceptible tumor cellsDNA damageLevels of p53Low p53 levelsApoptosis of cellsTherapy resistanceAntiintegrin antibodiesCancer cellsP53 levelsSurvival of cellsP53Nonadherent cellsCell typesSurvivalApoptotic responseCellsP19 ARFApoptosisChromosomal instabilityFibroblastic cell typesDamageChemotherapy
1997
Integrins, adhesion and apoptosis
Meredith J, Schwartz M. Integrins, adhesion and apoptosis. Trends In Cell Biology 1997, 7: 146-150. PMID: 17708932, DOI: 10.1016/s0962-8924(97)01002-7.Peer-Reviewed Original ResearchInsulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo.
Brooks P, Klemke R, Schon S, Lewis J, Schwartz M, Cheresh D. Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. Journal Of Clinical Investigation 1997, 99: 1390-1398. PMID: 9077549, PMCID: PMC507955, DOI: 10.1172/jci119298.Peer-Reviewed Original ResearchConceptsAlpha v beta 5Integrin alpha v beta 5Beta 5Growth factor-mediated signalsInsulin-like growth factor receptorSpontaneous pulmonary metastasesTumor cell metastasisMultiple tumor cell typesGrowth factor receptorIntegrin ligationCell motilityAdhesion proteinsTumor cell interactionsFunctional cooperationTumor cell growthCytokine receptorsTumor cell typesPulmonary metastasesCell typesCell metastasisCell growthMultiple tumor typesMetastatic cascadeTumor cellsFactor receptor
1994
Immunolocalization of anion exchanger AE2 and cation exchanger NHE-1 in distinct adjacent cells of gastric mucosa
Stuart-Tilley A, Sardet C, Pouyssegur J, Schwartz M, Brown D, Alper S. Immunolocalization of anion exchanger AE2 and cation exchanger NHE-1 in distinct adjacent cells of gastric mucosa. American Journal Of Physiology 1994, 266: c559-c568. PMID: 8141271, DOI: 10.1152/ajpcell.1994.266.2.c559.Peer-Reviewed Original ResearchConceptsBasolateral membraneExchanger proteinParietal cellsExchanger NHE-1Isoform-specific antibodiesMucous neck cellsNHE-1Secretory machineryTransporter proteinsNeck cellsMolecular identityHigh abundanceMucous cellsCarbonic anhydrase IICell typesAnion exchanger 2Cellular dispositionProteinAnion exchanger AE2Surface mucous cellsMorphological evidenceAdjacent cellsBand 3Exchanger 2Mucous neckIntegrins as Signal Transducing Receptors
Schwartz M. Integrins as Signal Transducing Receptors. 1994, 33-47. DOI: 10.1016/b978-0-08-091729-0.50007-3.Peer-Reviewed Original ResearchSignal transducing receptorsExtracellular matrixProtein kinase CCell functionIntracellular second messengerRole of integrinsCytoskeletal organizationInositol lipidsCell shapeSecond messengerKinase CAnchorage-dependent cellsSuch messengersCell typesContact of cellsOnly adhesionIntegrinsMessengerActivation of plateletsCellsCytoskeletonRecent dataReceptorsAdhesionDifferentiation
1993
The extracellular matrix as a cell survival factor.
Meredith J, Fazeli B, Schwartz M. The extracellular matrix as a cell survival factor. Molecular Biology Of The Cell 1993, 4: 953-961. PMID: 8257797, PMCID: PMC275725, DOI: 10.1091/mbc.4.9.953.Peer-Reviewed Original ResearchConceptsCell survival factorExtracellular matrixCell typesSurvival factorCell deathTyrosine phosphatase inhibitor sodium orthovanadateCell suicide pathwayRapid cell deathSuicide pathwayECM interactionsDNA degradationHuman endothelial cellsSodium orthovanadateCell growthPCDNucleus fragmentationTRPM-2Cell morphologyVascular cell adhesion molecule-1Class I histocompatibility antigenCell viabilityGrowth factorSpecific hormonesEndothelial cellsPotential role