Mathieu Bakhoum, MD, PhD
Assistant Professor of Ophthalmology and Visual ScienceCards
About
Research
Overview
Medical Research Interests
Publications
2024
Retinal Ischemic Perivascular Lesions Are Associated With Stroke in Individuals With Atrial Fibrillation
Bakhoum C, Au A, Bousquet E, Matesva M, Singer M, Jayaraj C, Romero‐Morales V, Somisetty S, Santina A, Bajar B, DeMaria A, Goldbaum M, Meadows J, Spatz E, Sarraf D, Bakhoum M. Retinal Ischemic Perivascular Lesions Are Associated With Stroke in Individuals With Atrial Fibrillation. Journal Of The American Heart Association 2024, 13: e035079. PMID: 39190603, PMCID: PMC11646541, DOI: 10.1161/jaha.123.035079.Peer-Reviewed Original ResearchStandardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop
Chew E, Burns S, Abraham A, Bakhoum M, Beckman J, Chui T, Finger R, Frangi A, Gottesman R, Grant M, Hanssen H, Lee C, Meyer M, Rizzoni D, Rudnicka A, Schuman J, Seidelmann S, Tang W, Adhikari B, Danthi N, Hong Y, Reid D, Shen G, Oh Y. Standardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop. Nature Reviews Cardiology 2024, 22: 47-63. PMID: 39039178, DOI: 10.1038/s41569-024-01060-8.Peer-Reviewed Original ResearchPrimary care dataMicrovascular diseaseDiverse at-risk populationsCardiovascular diseaseRetinal biomarkersOphthalmic imaging techniqueRisk of cardiovascular diseaseRetinal microvascular diseaseIndividual-level riskAt-risk populationsMacrovascular risk factorsSystemic vascular bedsDevelopment of microvascular diseaseCoronary artery diseaseHealth workersCare dataLifestyle factorsMonitoring of systemic diseasesRetinal imaging biomarkersNational HeartVascular dementiaBlood InstituteHeart failureMultidisciplinary networkSystemic diseaseSystems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
Trogdon M, Abbott K, Arang N, Lande K, Kaur N, Tong M, Bakhoum M, Gutkind J, Stites E. Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation. Npj Systems Biology And Applications 2024, 10: 75. PMID: 39013872, PMCID: PMC11252164, DOI: 10.1038/s41540-024-00400-1.Peer-Reviewed Original ResearchConceptsSignaling networksMathematical models of biochemical reaction networksModels of biochemical reaction networksG-proteinCell signaling networksDisease-causing mutationsComputational systems biologyBiochemical reaction networksDownstream pathway activationSignaling phenotypeSystems biologyBioinformatics analysisGPCR signalingMutationsCo-occurring mutationsOncogenic mutationsPathway activationDiscovery toolPathwayReaction networkSignalCYSLTR2 mutationsDiscoveryPhenotypeMutually-exclusiveRetinal Ischemic Perivascular Lesions Are Associated With Myocardial Infarction in Patients With Coronary Artery Disease
Bousquet E, Santina A, Au A, Somisetty S, Abraham N, Voichanski S, Estawro R, Fouad Y, Romero-Morales V, Bakhoum M, Sarraf D. Retinal Ischemic Perivascular Lesions Are Associated With Myocardial Infarction in Patients With Coronary Artery Disease. American Journal Of Ophthalmology 2024, 264: 224-228. PMID: 38552932, DOI: 10.1016/j.ajo.2024.03.017.Peer-Reviewed Original ResearchCoronary artery diseaseSD-OCTBody mass indexMyocardial infarctionAssociated with MIMacular spectral-domain optical coherence tomographyMass indexPerivascular lesionsSpectral-domain optical coherence tomographyArtery diseaseSmoking statusMultivariate logistic regression analysisMedical management of coronary artery diseaseManagement of coronary artery diseaseOptical coherence tomographyNon-MI groupHistory of MIAssociated with myocardial infarctionLogistic regression analysisPotential clinical utilityConsecutive patientsOCT scansCoherence tomographyOdds ratioMedical management
2023
Differentiating Lupus Nephritis Classes Using Peripheral Blood DNA Methylation
Bakhoum C, Faulkner S, Ix J, Moledina D, Bakhoum M. Differentiating Lupus Nephritis Classes Using Peripheral Blood DNA Methylation. Journal Of The American Society Of Nephrology 2023, 34: 243-243. DOI: 10.1681/asn.20233411s1243b.Peer-Reviewed Original Research
Clinical Care
Overview
Mathieu Bakhoum, MD, PhD, is an ophthalmologist who specializes in vitreoretinal surgery. At Yale Eye Center, Dr. Bakhoum treats patients with complex retinal diseases such as age-related macular degeneration, diabetic retinopathy, retinal detachment, epiretinal membrane, and retinal artery and vein occlusions.
As an assistant professor of ophthalmology and visual science at Yale School of Medicine, Dr. Bakhoum aims to improve the diagnosis and treatment of eye diseases, particularly focusing on uveal melanoma and systemic diseases detectable through the retina. His studies have identified new mechanisms of cancer cell aggression and the potential of retinal biomarkers to indicate cardiovascular diseases, enabling earlier interventions and better patient outcomes.
Dr. Bakhoum received his medical and doctorate degrees from the University of Texas Medical Branch. He completed his residency at Nassau University Medical Center and The University of Texas Medical Branch, followed by a fellowship in vitreoretinal surgery at the University of California, San Diego School of Medicine.
In addition to his clinical and research roles, Dr. Bakhoum teaches courses in ophthalmology and actively mentors students, residents, and fellows, fostering an environment of learning and inquiry. He has contributed to numerous publications in top-tier journals and presented at national and international conferences.
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Board Certifications
Ophthalmology
- Certification Organization
- AB of Ophthalmology
- Original Certification Date
- 2020
Yale Medicine News
News
News
- July 11, 2024Source: Yale Ventures
11 Yale Projects Receive Awards from the Colton Center for Autoimmunity
- May 11, 2023
Dr. Mathieu Bakhoum Receives Award for R21 Grant from the NEI for a Project of Pterygium Progression
- April 25, 2023
Mathieu Bakhoum, MD, PhD, Awarded Major Grant from the Department of Defense
- November 03, 2022
Mathieu Bakhoum, MD Recipient of Grant from Connecticut Lions Eye Research Foundation
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