2025
Genomic Landscape of Late-Stage Gastric Cancer: Analysis From KEYNOTE-059, KEYNOTE-061, and KEYNOTE-062 Studies
Janjigian Y, Cecchini M, Shitara K, Enzinger P, Wainberg Z, Chau I, Satoh T, Lee J, Nebozhyn M, Loboda A, Kobie J, Vajdi A, Shih C, Cristescu R, Cao Z. Genomic Landscape of Late-Stage Gastric Cancer: Analysis From KEYNOTE-059, KEYNOTE-061, and KEYNOTE-062 Studies. JCO Precision Oncology 2025, 9: e2400456. PMID: 40117530, PMCID: PMC11949223, DOI: 10.1200/po-24-00456.Peer-Reviewed Original ResearchConceptsTumor mutational burdenHomologous recombination deficiencyMicrosatellite instability-highGenomic characteristicsChromosomal instabilityKEYNOTE-062Late-stage GCKEYNOTE-059KEYNOTE-061Molecular subtypesAsian originWhole-exome sequencingGastric cancerSubtype prevalenceEpstein-Barr virus-positiveHomologous recombination deficiency scoresPretreatment tumor samplesWES dataGene expression signaturesCancer Genome AtlasMicrosatellite instability-high subtypeRNA sequencingGenomic landscapeEarly-stage GCGenomic alterations
2024
Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting
Prosz A, Sahgal P, Huffman B, Sztupinszki Z, Morris C, Chen D, Börcsök J, Diossy M, Tisza V, Spisak S, Likasitwatanakul P, Rusz O, Csabai I, Cecchini M, Baca Y, Elliott A, Enzinger P, Singh H, Ubellaker J, Lazaro J, Cleary J, Szallasi Z, Sethi N. Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting. Npj Precision Oncology 2024, 8: 87. PMID: 38589664, PMCID: PMC11001913, DOI: 10.1038/s41698-024-00561-6.Peer-Reviewed Original ResearchNucleotide excision repairGastric cancer cell linesNucleotide excision repair-deficientPlatinum chemotherapyHR deficiencyCancer cell linesPARP inhibitorsHomologous recombinationGenome sequence dataSensitivity to platinum chemotherapySingle-cell RNA sequencingCell linesHR-deficient cancersDNA repair pathwaysSensitivity to cisplatinRad51 foci assaysMutational signature analysisSequence dataGenomic featuresWhole exomeInduce apoptosisRNA sequencingGastroesophageal adenocarcinomaRepair pathwaysHRD score