Insights Into the Molecular and Cellular Underpinnings of Cutaneous T Cell Lymphoma.
Yumeen S, Girardi M. Insights Into the Molecular and Cellular Underpinnings of Cutaneous T Cell Lymphoma. The Yale Journal Of Biology And Medicine 2020, 93: 111-121. PMID: 32226341, PMCID: PMC7087059.Peer-Reviewed Original ResearchConceptsGenomic copy number alterationsSingle nucleotide variantsCutaneous T-cell lymphomaCellular underpinningsJAK-STAT activationT-cell lymphomaT lymphocytesCopy number alterationsCTCL cellsSeries of alterationsWhole-exome sequencingCell lymphomaApoptosis resistanceNucleotide variantsOncogenic behaviorPathophysiology of CTCLSkin-homing T lymphocytesT cell activationCell expansionNumber alterationsCTCL pathogenesisGenetic alterationsGenomic alterationsCell-mediated immunityTherapeutic discovery