2006
Hormonal Regulation of Nuclear Permeability* ♦
O'Brien EM, Gomes DA, Sehgal S, Nathanson MH. Hormonal Regulation of Nuclear Permeability* ♦. Journal Of Biological Chemistry 2006, 282: 4210-4217. PMID: 17158097, PMCID: PMC2835336, DOI: 10.1074/jbc.m606300200.Peer-Reviewed Original ResearchConceptsProtein kinase CNuclear permeabilityGene transcriptionNuclear envelopeSecond messengerKinase CPhotoactivatable green fluorescent proteinCertain G protein-coupled receptorsG protein-coupled receptorsActivate protein kinase CCytosolic Ca2Protein-coupled receptorsGreen fluorescent proteinTargeting sequenceTranscription factorsRegulatory moleculesNuclear membraneFluorescent proteinPassage of moleculesIntranuclear eventsNovel mechanismShort-term regulationHormonal regulationTranscriptionRegulation
2001
Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia
Dranoff J, Masyuk A, Kruglov E, LaRusso N, Nathanson M. Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. AJP Gastrointestinal And Liver Physiology 2001, 281: g1059-g1067. PMID: 11557527, DOI: 10.1152/ajpgi.2001.281.4.g1059.Peer-Reviewed Original ResearchConceptsP2Y receptor subtypesP2Y receptorsReceptor subtypesIntrahepatic bile duct unitsATP receptorsBile duct epitheliumMultiple P2Y receptor subtypesRat bile duct epitheliaBile duct unitsImportant regulatorLuminal ATPLuminal perfusionMolecular subtypesBile secretionDuct epitheliumBasolateral additionExtracellular nucleotidesDuctular secretionSubtypesCytosolic Ca2Duct unitsRT-PCRCholangiocytesReceptorsSecretionStimulation of ATP secretion in the liver by therapeutic bile acids
NATHANSON M, BURGSTAHLER A, MASYUK A, LaRUSSO N. Stimulation of ATP secretion in the liver by therapeutic bile acids. Biochemical Journal 2001, 358: 1-5. DOI: 10.1042/bj3580001.Peer-Reviewed Original ResearchBile duct epitheliumUrsodeoxycholic acidBile acidsSecretory disordersATP receptorsPerfusion of ATPBile duct segmentsEndogenous ATPTherapeutic bile acidsSecretion of ATPNumber of disordersMechanism of actionBile flowPharmacological activationPharmacological meansTherapeutic benefitElectrolyte secretionDelivery of ATPATP secretionCystic fibrosisOnly agentATP releaseBileCytosolic Ca2Liver
1999
Expression and subcellular localization of the ryanodine receptor in rat pancreatic acinar cells
LEITE M, DRANOFF J, Ling G, NATHANSON M. Expression and subcellular localization of the ryanodine receptor in rat pancreatic acinar cells. Biochemical Journal 1999, 337: 305-309. DOI: 10.1042/bj3370305.Peer-Reviewed Original ResearchPancreatic acinar cellsNon-excitable cell typesCell typesCell types resultsAcinar cellsNon-excitable cellsRyanodine receptorSubcellular localizationPolarized epitheliumReverse transcription-PCRRat pancreatic acinar cellsTrisphosphate receptorCo-ordinated releaseType 2 RyRExcitable cellsRelease pathwayTranscription-PCRPrincipal Ca2Release channelApical regionCytosolic Ca2CellsFundamental roleRyRsPropagation of Ca2
1998
Novel paracrine signaling mechanism in the ocular ciliary epithelium
Hirata K, Nathanson M, Sears M. Novel paracrine signaling mechanism in the ocular ciliary epithelium. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 8381-8386. PMID: 9653195, PMCID: PMC20984, DOI: 10.1073/pnas.95.14.8381.Peer-Reviewed Original ResearchConceptsNonpigmented cell layerCiliary epithelial bilayerAlpha1-adrenergic antagonist prazosinBeta-adrenergic antagonist propranololPigmented cell layerGap junction blocker octanolBeta-adrenergic agonist isoproterenolCell layerEpithelial bilayerEndogenous adenylyl cyclaseGap junctionsCell spreadOcular ciliary epitheliumAntagonist prazosinAqueous humor secretionAntagonist propranololCiliary bodyAgonist isoproterenolParacrine pathwaysAdrenergic stimulationNovel paracrineCytosolic Ca2Lucifer YellowCiliary epitheliumAdenylyl cyclase
1997
Intercellular Calcium Signaling in Liver
Nathanson M, Fallon M, Burgstahler A, Mennone A, Schlosser S, Gonzalez C, Sáez J. Intercellular Calcium Signaling in Liver. Series Of The Centro De Estudios Científicos 1997, 469-481. DOI: 10.1007/978-1-4899-1795-9_27.Peer-Reviewed Original ResearchGap junctionsGap junction expressionIntercellular calcium signalingDiverse cell functionsExcitable cell typesBile secretionIsolated cell systemImportant second messengerJunction expressionCytosolic Ca2Experimental modelHormonal stimulationCell functionPhysiological circumstancesCalcium signalingIntercellular signalingHepatocytesSecond messengerOrgan-level responsesPreliminary evidenceLiverCell typesCai2Inositol 1Signaling
1994
Effects of protein kinase C and cytosolic Ca2+ on exocytosis in the isolated perfused rat liver
Bruck R, Nathanson M, Roelofsen H, Boyer J. Effects of protein kinase C and cytosolic Ca2+ on exocytosis in the isolated perfused rat liver. Hepatology 1994, 20: 1032-1040. PMID: 7927205, DOI: 10.1002/hep.1840200436.Peer-Reviewed Original ResearchConceptsProtein kinase CKinase CApical exocytosisRegulation of exocytosisProtein kinase C inhibitor HHorseradish peroxidase concentrationCytosolic Ca2ExocytosisCell typesInhibitor HProtein kinase C activator phorbol dibutyrateHorseradish peroxidase excretionPhorbol dibutyrateCa2Rat liverRelative importanceNet excretionPeroxidase concentrationsHepatocytesCellular and subcellular calcium signaling in gastrointestinal epithelium
Nathanson M. Cellular and subcellular calcium signaling in gastrointestinal epithelium. Gastroenterology 1994, 106: 1349-1364. PMID: 8174894, DOI: 10.1016/0016-5085(94)90030-2.Peer-Reviewed Original ResearchConceptsCell typesCritical second messengerEpithelial cell typesEpithelial cellsIndividual epithelial cellsPolarized epitheliumSecond messengerMechanism of Ca2Polarized structureGastrointestinal tractProlonged elevationGastrointestinal epitheliumCell populationsSubcellular calciumSubcellular Ca2Cytosolic Ca2Digestive systemCellsFurther levelCa2EpitheliumSuch signalsSignalingMessengerPancreas
1993
Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes
Beuers U, Nathanson M, Boyer J. Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes. Gastroenterology 1993, 104: 604-612. PMID: 8425704, DOI: 10.1016/0016-5085(93)90433-d.Peer-Reviewed Original ResearchConceptsEffect of TUDCATauroursodeoxycholic acidAdministration of TUDCAIP3-independent mechanismCytosolic free calciumIP3-sensitive Ca2Trihydroxy bile acidsCholestatic disordersHepatocyte secretionTreatment periodExtracellular Ca2Bile acidsTaurolithocholic acidMumol/Rat hepatocytesFree calciumBasal levelsTransient increaseCytosolic Ca2Levels of inositolFree mediumPhysiological concentrationsIsolated rat hepatocytesHepatocytesFourfold increase
1992
Effects of Ca2+ agonists on cytosolic Ca2+ in isolated hepatocytes and on bile secretion in the isolated perfused rat liver
Nathanson M, Gautam A, Bruck R, Isales C, Boyer J. Effects of Ca2+ agonists on cytosolic Ca2+ in isolated hepatocytes and on bile secretion in the isolated perfused rat liver. Hepatology 1992, 15: 107-116. PMID: 1727785, DOI: 10.1002/hep.1840150119.Peer-Reviewed Original ResearchConceptsBile flowPerfusion pressureBile secretionCytosolic Ca2Rat liverProtein kinase CIonophore-induced increaseBromo-A23187Hepatic vasoconstrictionVasodilator papaverineProtein kinase C inhibitor HExtracellular Ca2Kinase CSecretionLiverVasopressinAgonist vasopressinBenzohydroquinoneEffect of Ca2HepatocytesActivate protein kinase CInhibitor HTwo-thirdsIsolated hepatocytesSensitive photoprotein aequorin