2019
Detecting FLI1 Fusion by Immunohistochemistry (IHC) Stain in Prostatic Adenocarcinoma
Xu K, Budhai A, Pattarkine R, Zhong M. Detecting FLI1 Fusion by Immunohistochemistry (IHC) Stain in Prostatic Adenocarcinoma. American Journal Of Clinical Pathology 2019, 152: s72-s73. DOI: 10.1093/ajcp/aqz113.087.Peer-Reviewed Original ResearchIHC stainsProstate cancerProstatic adenocarcinomaERG fusionNext-generation sequencingProstate adenocarcinoma casesTMA slidesE26 transformation-specific familyCommon genetic alterationsTissue microarray constructionAdenocarcinoma casesIHC stainingImmunohistochemistry stainsPositive casesMRNA level increasesTumor cellsNuclear stainingTCGA dataGenetic alterationsNontumor cellsSection slidesAdenocarcinomaCancerSurrogate testStain
2018
334 Whole Exome Sequencing of End Stage Renal Disease Associated Papillary Renal Cell Carcinoma (PRCCs)
Farooq T, Saeed F, Zhang D, Huang W, Yin C, Zhong M. 334 Whole Exome Sequencing of End Stage Renal Disease Associated Papillary Renal Cell Carcinoma (PRCCs). American Journal Of Clinical Pathology 2018, 149: s144-s144. DOI: 10.1093/ajcp/aqx127.333.Peer-Reviewed Original ResearchEnd-stage renal diseasePapillary renal cell carcinomaRenal cell carcinomaSporadic papillary renal cell carcinomasWhole-exome sequencingCell carcinomaExome sequencingSurgical pathology databaseSporadic renal cell carcinomaSpecific genetic alterationsParaffin-embedded tissuesGenomic DNARenal diseasePathology databaseCarcinomaProfile levelsGene mutationsGenetic mutationsGenetic alterationsFrequent mutationsMolecular changesSingle nucleotide variantsTargeted sequencingHuge overlapRNA kit
2001
Transformation of Cells Overexpressing a Tyrosine Kinase by Phospholipase D1 and D2
Joseph T, Wooden R, Bryant A, Zhong M, Lu Z, Foster D. Transformation of Cells Overexpressing a Tyrosine Kinase by Phospholipase D1 and D2. Biochemical And Biophysical Research Communications 2001, 289: 1019-1024. PMID: 11741292, DOI: 10.1006/bbrc.2001.6118.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorTransformation of cellsTyrosine kinaseElevated tyrosine kinase activityElevated expressionTyrosine kinase activityGTPase cascadeMembrane microdomainsPhospholipase D activityTransform cellsPLD genesGrowth factor receptorC-SrcMitogenic signalsGene productsDownstream targetsKinase activityOncogenic signalingPhospholipase D1PLD2Common genetic alterationsHuman cancersKinaseMalignant phenotypeGenetic alterations