2003
Ectopic LTαβ Directs Lymphoid Organ Neogenesis with Concomitant Expression of Peripheral Node Addressin and a HEV-restricted Sulfotransferase
Drayton DL, Ying X, Lee J, Lesslauer W, Ruddle NH. Ectopic LTαβ Directs Lymphoid Organ Neogenesis with Concomitant Expression of Peripheral Node Addressin and a HEV-restricted Sulfotransferase. Journal Of Experimental Medicine 2003, 197: 1153-1163. PMID: 12732657, PMCID: PMC2193975, DOI: 10.1084/jem.20021761.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEnzyme InductionImmunohistochemistryLymphoid TissueLymphotoxin-alphaLymphotoxin-betaMembrane ProteinsMiceMice, TransgenicSulfotransferasesConceptsHigh endothelial venulesPeripheral node addressinLymphoid organogenesisLT-alphaB cell compartmentalizationMucosal addressin cell adhesion moleculeAlpha betaLymph node functionB-cell areasAntigen presenting cellsLymphoid neogenesisPancreatic infiltratesPNAd expressionLymphoid chemokinesFDC networksMononuclear infiltrateAlpha micePresenting cellsEndothelial venulesCell adhesion moleculeCell accumulationLT-betaAdhesion moleculesNode functionPancreata
1997
Distinct Roles in Lymphoid Organogenesis for Lymphotoxins α and β Revealed in Lymphotoxin β–Deficient Mice
Koni P, Sacca R, Lawton P, Browning J, Ruddle N, Flavell R. Distinct Roles in Lymphoid Organogenesis for Lymphotoxins α and β Revealed in Lymphotoxin β–Deficient Mice. Immunity 1997, 6: 491-500. PMID: 9133428, DOI: 10.1016/s1074-7613(00)80292-7.Peer-Reviewed Original ResearchConceptsMesenteric lymph nodesLT alpha-deficient miceAlpha-deficient miceFollicular dendritic cellsBeta-deficient miceLymph nodesDendritic cellsDeficient miceLymphoid organogenesisTumor necrosis factor receptor type ILTbeta-deficient micePeripheral lymph nodesReceptor type ISplenic germinal centersLymphotoxin βPeyer's patchesGerminal centersLymphotoxin alphaLT-alphaLT alpha3Lymphotoxin αMiceUnidentified receptorType IAlpha