Kap-ÎČ2/Transportin mediates ÎČ-catenin nuclear transport in Wnt signaling
Hwang WY, Kostiuk V, GonzĂĄlez DP, Lusk CP, Khokha M. Kap-ÎČ2/Transportin mediates ÎČ-catenin nuclear transport in Wnt signaling. ELife 2022, 11: e70495. PMID: 36300792, PMCID: PMC9665845, DOI: 10.7554/elife.70495.Peer-Reviewed Original ResearchConceptsNuclear transport receptorsÎ-catenin nuclear transportNuclear transportÎ-cateninExcessive WntÎ-catenin nuclear importHeterologous model systemsÎ-catenin accumulatesPrimary embryonic axisNuclear transport machineryRan-dependent mannerNuclear localization signalTCF/LEF reporterPY-NLSNuclear importLocalization signalTransport machineryTransport receptorsResponsive genesEmbryonic developmentEmbryonic axisWnt signalingKey effectorsDirect bindingHuman diseases