Featured Publications
Single-Cell Analysis Reveals a Hair Follicle Dermal Niche Molecular Differentiation Trajectory that Begins Prior to Morphogenesis
Gupta K, Levinsohn J, Linderman G, Chen D, Sun TY, Dong D, Taketo MM, Bosenberg M, Kluger Y, Choate K, Myung P. Single-Cell Analysis Reveals a Hair Follicle Dermal Niche Molecular Differentiation Trajectory that Begins Prior to Morphogenesis. Developmental Cell 2018, 48: 17-31.e6. PMID: 30595533, PMCID: PMC6361530, DOI: 10.1016/j.devcel.2018.11.032.Peer-Reviewed Original ResearchConceptsDermal condensatesSingle-cell RNA sequencingUnbiased single-cell RNA sequencingWnt/β-catenin signalingΒ-catenin signalingTranscriptional statesDifferentiation trajectoriesAppendage morphogenesisRNA sequencingHF morphogenesisCellular eventsRecent progenyCell differentiationMorphogenesisClusters of cellsMolecular differencesDistinctive populationCell analysisCellsDifferentiationHF developmentProgenySignalingDC cellsSequencing
2019
A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease
Sun Q, Lee W, Mohri Y, Takeo M, Lim CH, Xu X, Myung P, Atit RP, Taketo MM, Moubarak RS, Schober M, Osman I, Gay DL, Saur D, Nishimura EK, Ito M. A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease. Nature Communications 2019, 10: 5023. PMID: 31685822, PMCID: PMC6828673, DOI: 10.1038/s41467-019-12733-1.Peer-Reviewed Original ResearchConceptsMouse modelNovel mouse modelMelanoma progression modelDeadly skin cancerAnimal modelsSkin cancerBona fide sourceAdvanced stageMelanoma inductionMalignant transformationHuman melanomaMelanomaGene signatureAnagen onsetMolecular profilingMelanoma initiationMelanocyte stem cellsNormal WntStem cellsProgression modelHuman diseasesRecent studiesCancerDiseaseProgression
2018
Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing
Lim CH, Sun Q, Ratti K, Lee SH, Zheng Y, Takeo M, Lee W, Rabbani P, Plikus MV, Cain JE, Wang DH, Watkins DN, Millar S, Taketo MM, Myung P, Cotsarelis G, Ito M. Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing. Nature Communications 2018, 9: 4903. PMID: 30464171, PMCID: PMC6249328, DOI: 10.1038/s41467-018-07142-9.Peer-Reviewed Original ResearchConceptsSonic hedgehog pathwayMechanisms of scarringHair follicle neogenesisHF neogenesisFibrotic repairScarring woundsMurine skinShh overexpressionWound repairHair follicle regenerationWound healingFollicle neogenesisHedgehog pathwayDermal papillaWnt activationFibrosisWoundsScarringHealingSignal activationNeogenesisActivation resultsMammalian woundsActivationFollicle regeneration
2015
Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool
Mesa KR, Rompolas P, Zito G, Myung P, Sun TY, Brown S, Gonzalez DG, Blagoev KB, Haberman AM, Greco V. Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool. Nature 2015, 522: 94-97. PMID: 25849774, PMCID: PMC4457634, DOI: 10.1038/nature14306.Peer-Reviewed Original Research