2024
National Patterns of Hospital Admission Versus Home Recovery Following Mastectomy for Breast Cancer
Kim L, Moore M, Schneider E, Canner J, Ayyala H, Chen J, Anant P, Graetz E, Lynch M, Zanieski G, Gillego A, Valero M, Proussaloglou E, Berger E, Golshan M, Greenup R, Park T. National Patterns of Hospital Admission Versus Home Recovery Following Mastectomy for Breast Cancer. Annals Of Surgical Oncology 2024, 1-12. PMID: 39322830, DOI: 10.1245/s10434-024-16107-w.Peer-Reviewed Original ResearchHR patientsLymph nodesRate of neoadjuvant chemotherapyHospital admissionNational patterns of careEmergency departmentDecrease wound complicationsNeoadjuvant chemo-Hospital re-admissionNeoadjuvant chemotherapyIn-hospital admissionRate of reconstructionPerioperative outcomesPostoperative hematomaComplication ratePostoperative complicationsWound complicationsHome recoveryPatterns of careBreast cancerMastectomyEmergency room visitsMultivariate analysisComplicationsPatientsImpact of Financial Costs on Patients' Fertility Preservation Decisions: An Examination of Qualitative Data from Female Young Adults with Cancer and Oncology Providers
Dorfman C, Stalls J, Shelby R, Arthur S, Acharya K, Davidson B, Corbett C, Greenup R. Impact of Financial Costs on Patients' Fertility Preservation Decisions: An Examination of Qualitative Data from Female Young Adults with Cancer and Oncology Providers. Journal Of Adolescent And Young Adult Oncology 2024, 13: 502-513. PMID: 38294823, DOI: 10.1089/jayao.2023.0108.Peer-Reviewed Original ResearchFertility preservation decisionsFertility preservationImpact of financial costsFemale young adultsYoung adultsFamily building goalsHistory of cancerPreservation decisionsInsurance coverageOncology providersProviders expressed concernsCancer patientsComprehensive cancer centerReproductive ageCancer CenterNational Cancer Institute-designated comprehensive cancer centerCancer Institute-designated comprehensive cancer centerReproductive specialistsPatientsBuilding goalsCancer
2023
Racioethnic differences in missing data in the national cancer database: A window into inequities in cancer care.
Raman V, Migaly J, Greenup R, Tong B, Fayanju O. Racioethnic differences in missing data in the national cancer database: A window into inequities in cancer care. Journal Of Clinical Oncology 2023, 41: e18502-e18502. DOI: 10.1200/jco.2023.41.16_suppl.e18502.Peer-Reviewed Original ResearchNational Cancer DatabaseHispanic patientsCancer careClinical stagingWhite patientsCancer DatabaseTreatment statusTreatment documentationMultivariable logistic regression modelGuideline-concordant careMultivariable logistic regressionDiagnosis of cancerNon-Hispanic whitesLogistic regression modelsRace/ethnicityPrimary outcomeLung cancerObservational studyStudy populationPatientsStage ILogistic regressionPearson's ChiCompleteness of dataStudy of cancerSurgery in the Setting of Metastatic Breast Cancer
Plichta J, Taskindoust M, Greenup R. Surgery in the Setting of Metastatic Breast Cancer. Current Breast Cancer Reports 2023, 15: 37-47. DOI: 10.1007/s12609-023-00476-4.Peer-Reviewed Original ResearchMetastatic breast cancerSurvival benefitBreast cancerSurgical resectionPrimary tumorSelect patient groupsPotential survival benefitPrimary breast tumorsLocoregional treatmentMetastatic diseaseMost patientsPatient groupProspective studyRetrospective studySelect subgroupClinical scenariosBreast tumorsResectionTumorsCancerLimited benefitSurgeryPatientsMixed resultsDiseaseModifiable Barriers and Facilitators for Breast Cancer Care: A Thematic Analysis of Patient and Provider Perspectives
Fayanju O, Greenup R, Zafar S, Hyslop T, Hwang E, Fish L. Modifiable Barriers and Facilitators for Breast Cancer Care: A Thematic Analysis of Patient and Provider Perspectives. Journal Of Surgical Research 2023, 284: 269-279. PMID: 36610386, PMCID: PMC10020986, DOI: 10.1016/j.jss.2022.11.074.Peer-Reviewed Original ResearchConceptsBreast cancer treatmentBreast cancerModifiable barriersCancer treatmentProvider perspectivesSurgical oncology careBreast cancer careAdvanced practice providersSingle health systemModifiable contributorOncologic careModifiable factorsOncology careCancer careTreatment receiptPatients' perceptionsStage 0Practice providersCare receiptPatientsExemplar quotesThematic analysisSuboptimal communicationHealth systemTreatment costs
2022
Genetic testing in privately insured women with surgically treated breast cancer
Dinan M, Pitafi S, Greenup R, Long J, Gross C. Genetic testing in privately insured women with surgically treated breast cancer. Breast Cancer Research And Treatment 2022, 198: 177-181. PMID: 36542252, DOI: 10.1007/s10549-022-06829-4.Peer-Reviewed Original ResearchConceptsBreast cancerGenetic testingRoutine breast cancer careBRCA1/BRCA2 genetic testingHormone receptor statusBreast cancer careInvasive breast cancerBRCA2 genetic testingReceptor statusWomen 50Cancer careAge 45Family historyOlder womenInsurer databaseYoung womenCancerWomenCoverage policiesUnclear implicationsPatientsSurgeryPurposeRatesYearsPrevalence
2020
Missing data in breast cancer: Relationship with survival in national databases.
Plichta J, Rushing C, Lewis H, Blazer D, Hyslop T, Greenup R. Missing data in breast cancer: Relationship with survival in national databases. Journal Of Clinical Oncology 2020, 38: e19114-e19114. DOI: 10.1200/jco.2020.38.15_suppl.e19114.Peer-Reviewed Original ResearchOverall survivalNational Cancer RegistryTumor variablesCancer RegistryBreast cancerLarge national cancer registryCox proportional hazards modelInvasive breast cancerPatterns of careInclusion/exclusion criteriaTreatment variablesProportional hazards modelRate of deathWorse OSOncology outcomesN stageOS differenceExclusion criteriaOutcome studiesHazards modelPatientsNCDBSurgery dataGreater riskNational database
2018
The Clinical Significance of Breast-only and Node-only Pathologic Complete Response (pCR) After Neoadjuvant Chemotherapy (NACT)
Fayanju O, Ren Y, Thomas S, Greenup R, Plichta J, Rosenberger L, Tamirisa N, Force J, Boughey J, Hyslop T, Hwang E. The Clinical Significance of Breast-only and Node-only Pathologic Complete Response (pCR) After Neoadjuvant Chemotherapy (NACT). Annals Of Surgery 2018, 268: 591-601. PMID: 30048319, PMCID: PMC6496955, DOI: 10.1097/sla.0000000000002953.Peer-Reviewed Original ResearchConceptsPathologic complete responseImproved overall survivalNeoadjuvant chemotherapyOverall survivalComplete responseBreast cancerHuman epidermal growth factor receptor 2 (HER2) statusEpidermal growth factor receptor 2 statusCox proportional hazards modelHormone receptorsNode-positive patientsTriple-negative diseaseKaplan-Meier curvesBreast cancer patientsMultivariate logistic regressionProportional hazards modelAnatomic extentCancer patientsReceptor subtypesClinical significanceHazards modelTumor subtypesPatientsBreastLogistic regression
2017
Pathologic Complete Response After Neoadjuvant Chemotherapy and Long-Term Outcomes Among Young Women With Breast Cancer.
Spring L, Greenup R, Niemierko A, Schapira L, Haddad S, Jimenez R, Coopey S, Taghian A, Hughes K, Isakoff S, Ellisen L, Smith B, Specht M, Moy B, Bardia A. Pathologic Complete Response After Neoadjuvant Chemotherapy and Long-Term Outcomes Among Young Women With Breast Cancer. Journal Of The National Comprehensive Cancer Network 2017, 15: 1216-1223. PMID: 28982747, DOI: 10.6004/jnccn.2017.0158.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorBreast NeoplasmsFemaleFollow-Up StudiesHumansMutationNeoadjuvant TherapyNeoplasm GradingNeoplasm StagingRecurrenceRegistriesRetrospective StudiesSurvival AnalysisTreatment OutcomeTriple Negative Breast NeoplasmsYoung AdultConceptsPathologic complete responseDisease-free survivalBaseline clinical stageNeoadjuvant chemotherapyOverall survivalBreast cancerYoung womenComplete responseClinical stageResidual diseaseInvasive breast cancerLong-term outcomesAggressive tumor biologyMassachusetts General HospitalDFS ratesNeoadjuvant therapyOS ratesSurvival outcomesSurrogate markerGeneral HospitalBest therapyHigh riskTrial designRapid triagePatients
2016
The Promise and Perils of Shared Decision-Making in Clinical Practice
Greenup R, Peppercorn J. The Promise and Perils of Shared Decision-Making in Clinical Practice. 2016, 293-305. DOI: 10.1007/978-1-4939-3486-7_21.Peer-Reviewed Original ResearchSurgeons’ Perspectives of Contralateral Prophylactic Mastectomy
Bellavance E, Peppercorn J, Kronsberg S, Greenup R, Keune J, Lynch J, Collyar D, Magder L, Tilburt J, Hlubocky F, Yao K. Surgeons’ Perspectives of Contralateral Prophylactic Mastectomy. Annals Of Surgical Oncology 2016, 23: 2779-2787. PMID: 27169770, DOI: 10.1245/s10434-016-5253-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAttitude of Health PersonnelComprehensionFemaleGenes, BRCA1Genes, BRCA2HumansMaleMedical OveruseMiddle AgedPatientsPractice Patterns, Physicians'Prophylactic MastectomyRisk AssessmentRisk FactorsSurgical OncologySurveys and QuestionnairesUnilateral Breast NeoplasmsConceptsContralateral prophylactic mastectomyOncologic benefitProphylactic mastectomyBreast cancerBenefits of CPMUnfavorable risk/benefit ratioUse of CPMRisk/benefit ratioAverage-risk patientsDeleterious BRCA mutationsProportion of surgeonsInadequate patient understandingPercent of respondentsMedian ageBRCA mutationsBreast diseaseBreast surgeonsPractice patternsRelative riskPatient understandingCommon reasonMost surgeonsMethodsA surveyPatientsSurgeonsPhysician Experience and Attitudes Toward Addressing the Cost of Cancer Care.
Altomare I, Irwin B, Zafar S, Houck K, Maloney B, Greenup R, Peppercorn J, Altomare I, Irwin B, Zafar S, Houck K, Maloney B, Greenup R, Peppercorn J. Physician Experience and Attitudes Toward Addressing the Cost of Cancer Care. JCO Oncology Practice 2016, 12: e281-8, 247-8. PMID: 26883407, PMCID: PMC4960469, DOI: 10.1200/jop.2015.007401.Peer-Reviewed Original ResearchConceptsCancer careCost discussionsRespondents' practice settingCost of careCancer doctorsPhysician experiencePatientsPocket costsPractice settingsASCO membersOptimal timingMajority of respondentsSocietal costsLack of consensusPrivate practiceSubstantial proportionCareElectronic surveyClinicPhysiciansPractice managementDoctorsDiscussion of costTotalLack of resources
2015
Diagnostic Value of Ultrasound in Female Patients With Nipple Discharge.
Bahl M, Baker J, Greenup R, Ghate S. Diagnostic Value of Ultrasound in Female Patients With Nipple Discharge. American Journal Of Roentgenology 2015, 205: 203-8. PMID: 26102400, DOI: 10.2214/ajr.14.13354.Peer-Reviewed Original ResearchConceptsPathologic nipple dischargeNipple dischargeInvasive adenocarcinomaSurgical excisionEvaluation of patientsDetection of DCISNormal sonographic findingsSpecificity of mammographySpecificity of ultrasoundUseful diagnostic toolContribution of ultrasoundBilateral mammographyFemale patientsPathologic featuresRadiologic findingsRetrospective reviewDuctal carcinomaSonographic findingsPathologic resultsStudy populationPatientsRoutine evaluationDiagnostic valueAdenocarcinomaUltrasound
2013
New Treatment Paradigms for Patients with Ductal Carcinoma In Situ
Mackey A, Greenup R, Hwang E. New Treatment Paradigms for Patients with Ductal Carcinoma In Situ. Current Breast Cancer Reports 2013, 5: 86-98. DOI: 10.1007/s12609-013-0109-9.Peer-Reviewed Original ResearchDuctal carcinomaDiagnosis of DCISNew treatment paradigmMolecular prognostic toolsMagnitude of benefitDCIS subtypesAdjuvant treatmentClinical factorsActive surveillanceTreatment paradigmTreatment strategiesBreast cancerIndividualized therapyPrognostic toolHeterogeneous lesionsClinical diagnosisDCISPatientsCarcinomaInvasive potentialDiagnosisLumpectomyMalignancyTherapyLesions