2022
“Near Cure” treatment of severe acute EAE in MIF-1-deficient female and male mice with a bifunctional MHCII-derived molecular construct
Vandenbark AA, Meza-Romero R, Wiedrick J, Gerstner G, Seifert H, Kent G, Piechycna M, Benedek G, Bucala R, Offner H. “Near Cure” treatment of severe acute EAE in MIF-1-deficient female and male mice with a bifunctional MHCII-derived molecular construct. Cellular Immunology 2022, 378: 104561. PMID: 35738135, PMCID: PMC9714992, DOI: 10.1016/j.cellimm.2022.104561.Peer-Reviewed Original ResearchConceptsExperimental autoimmune encephalomyelitisAcute experimental autoimmune encephalomyelitisDRα1-MOG-35Multiple sclerosisMIF-1EAE scoresMale miceMIF-2Severe diseaseMacrophage migration inhibitory factorClinical EAE scoresMIF-deficient micePeripheral inflammatory cellsMigration inhibitory factorSpinal cord tissueT cell activationSex-dependent differencesEAE severityAutoimmune encephalomyelitisSerum levelsTreatment of WTInflammatory cellsFemale miceClinical signsCord tissue
2013
Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects (P5221)
Benedek G, Meza-Romero R, Andrew S, Leng L, Burrows G, Bourdette D, Offner H, Bucala R, Vandenbark A. Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects (P5221). The Journal Of Immunology 2013, 190: 67.4-67.4. DOI: 10.4049/jimmunol.190.supp.67.4.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorExperimental autoimmune encephalomyelitisPartial MHC class II constructsCD74 cell-surface expressionMultiple sclerosisCell surface expressionMIF/CD74 interactionMigration inhibitory factorAutoimmune encephalomyelitisAlpha 1 domainInflammatory activityProinflammatory cytokinesHistological signsMIF activityAnti-apoptotic activityImmune systemInhibitory factorEnhanced secretionMHC complexesAntigenic peptidesCD74MIF effectsRandom migrationSurface expressionPivotal regulator