2024
Vitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study
Worhunsky P, Mignosa M, Gallezot J, Pittman B, Nabulsi N, Stryjewski A, Jalilian-Khave L, Trinko R, DiLeone R, Carson R, Malison R, Potenza M, Angarita G. Vitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study. Biological Psychiatry 2024 PMID: 39395473, DOI: 10.1016/j.biopsych.2024.09.028.Peer-Reviewed Original ResearchVentral striatumEffects of medicationDorsal caudateDopamine releaseDorsal putamenDopaminergic tonePlacebo-controlled within-subject studyIncreased amphetamine-induced dopamine releaseAmphetamine-induced dopamine releaseAmphetamine-stimulated dopamine releaseSubstantia nigraDysregulated dopamine functionPositron emission tomography studiesTreatment of ADHDEmission tomography studiesWithin-subject studyPost-amphetamineD2/3 receptorsDopamine functionTransdiagnostic relevanceVitamin DPhasic releaseGlobus pallidusStriatumTyrosine hydroxylase
2000
Measurement of dopamine release with continuous infusion of [11C]raclopride: optimization and signal-to-noise considerations.
Watabe H, Endres CJ, Breier A, Schmall B, Eckelman WC, Carson RE. Measurement of dopamine release with continuous infusion of [11C]raclopride: optimization and signal-to-noise considerations. Journal Of Nuclear Medicine 2000, 41: 522-30. PMID: 10716328.Peer-Reviewed Original ResearchConceptsOptimal timingAdministration of amphetamineReceptor imaging studiesHuman dataContinuous infusionDopamine releaseOptimal scan timeHealthy volunteersHuman studiesSynaptic dopamineImaging studiesPET studiesDopamine responsePercentage changeCareful assessmentStatistical significanceDeltaBPInfusionMeasurement of changesIndirect measureActivity curvesPrePatients
1997
Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method
Breier A, Su T, Saunders R, Carson RE, Kolachana BS, de Bartolomeis A, Weinberger DR, Weisenfeld N, Malhotra AK, Eckelman WC, Pickar D. Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 2569-2574. PMID: 9122236, PMCID: PMC20129, DOI: 10.1073/pnas.94.6.2569.Peer-Reviewed Original ResearchConceptsSynaptic dopamine concentrationsDopamine concentrationsDopamine outflowDopamine levelsStriatal extracellular dopamine levelsBinding reductionPositron emission tomography radioligandExtracellular dopamine levelsSynaptic dopamine levelsAmphetamine-induced changesNonhuman primate studiesPositron emission tomography (PET) methodDopamine overactivityPatients elevationNovel brain imaging methodVivo microdialysisAmphetamine doseDopamine receptorsClinical studiesDopamine releasePreclinical studiesHealthy volunteersBrain imaging methodsDopamine increasesTomography radioligand