ÎČ Cellâspecific deletion of Zfp148 improves nutrient-stimulated ÎČ cell Ca2+ responses
Emfinger CH, de Klerk E, Schueler KL, Rabaglia ME, Stapleton DS, Simonett SP, Mitok KA, Wang Z, Liu X, Paulo JA, Yu Q, Cardone RL, Foster HR, Lewandowski SL, Perales JC, Kendziorski CM, Gygi SP, Kibbey RG, Keller MP, Hebrok M, Merrins MJ, Attie AD. ÎČ Cellâspecific deletion of Zfp148 improves nutrient-stimulated ÎČ cell Ca2+ responses. JCI Insight 2022, 7: e154198. PMID: 35603790, PMCID: PMC9220824, DOI: 10.1172/jci.insight.154198.Peer-Reviewed Original ResearchConceptsCell-specific deletionÎ-cell Ca2Insulin secretionAmino acid metabolismLow glucose conditionsRNA-seqPancreatic ÎČ-cellsLevels of enzymesZfp148Glutamate dehydrogenaseIntermediary metabolismChannel closureEnhanced insulin secretionWestern-style dietControl mice fedElevated glucose levelsAcid metabolismÎ-cellsCell functionGlucose toleranceCell Ca2Elevated sensitivityGlucose conditionsMetabolic challengesMice fed