2016
Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers
Kothari N, Teer J, Abbott A, Srikumar T, Zhang Y, Yoder S, Brohl A, Kim R, Reed D, Shibata D. Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers. Cancer 2016, 122: 2828-2835. PMID: 27244218, PMCID: PMC5014625, DOI: 10.1002/cncr.30082.Peer-Reviewed Original ResearchConceptsColorectal cancerYounger patientsExome sequencingOutcomes of patientsSporadic colorectal cancerUnique genetic alterationsFisher's exact testCRC data setsWhole-exome sequencingWorse survivalRetrospective studyTreatment modalitiesBRAF mutationsPatientsExact testFBXW7 geneLarger studyOlder agePatient samplesCohortFinal analysisSporadic cancersStatistical significanceGenetic alterationsFuture screeningPortal Hypertension Over the Last 25 Years: Where Did It Go?
Rosemurgy A, Raitano O, Srikumar T, Sawangkum P, Luberice K, Ryan C, Ross S. Portal Hypertension Over the Last 25 Years: Where Did It Go? Journal Of The American College Of Surgeons 2016, 222: 1164-1170. PMID: 27234633, DOI: 10.1016/j.jamcollsurg.2016.02.017.Peer-Reviewed Original ResearchConceptsPercentage of patientsPortal hypertensionDecompressive shuntsHospital mortalityEndoscopic therapyEndoscopic treatmentNumber of patientsEsophageal varicesHealth care administrationHospital inpatientsHypertensionPatientsShuntDiagnosisCare administrationVaricesSurgeryTherapyMortalityTreatmentAdmissionInpatientsYearsSurgeonsAdministration
2015
Genetic analysis of colorectal cancers in young patients.
Abbott A, Kothari N, Teer J, Srikumar T, Kim R, Reed D, Shibata D. Genetic analysis of colorectal cancers in young patients. Journal Of Clinical Oncology 2015, 33: 632-632. DOI: 10.1200/jco.2015.33.3_suppl.632.Peer-Reviewed Original ResearchColorectal cancerYounger patientsExact testUnique molecular changesYoung CRC patientsFisher's exact testTargeted exome sequencingCRC patientsOlder patientsMedian ageWorse prognosisCRC casesTreatment strategiesHereditary syndromesHereditary cancer genesPatientsMutation frequencyNormal variantsExome sequencingGenetic alterationsDifferential mutation frequenciesGenetic conditionsMolecular changesOlder cohortSomatic mutations