Potential Use of Flavopiridol in Treatment of Chronic Diseases
Srikumar T, Padmanabhan J. Potential Use of Flavopiridol in Treatment of Chronic Diseases. Advances In Experimental Medicine And Biology 2016, 929: 209-228. PMID: 27771926, DOI: 10.1007/978-3-319-41342-6_9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory AgentsAntineoplastic Agents, PhytogenicAntiviral AgentsApoptosisCardiovascular AgentsCell Cycle CheckpointsCell ProliferationChronic DiseaseDisease Models, AnimalDrug DiscoveryFlavonoidsHumansMolecular StructurePhytotherapyPiperidinesPlants, MedicinalSignal TransductionConceptsChronic diseasesElicit anti-inflammatory activityAberrant cell cycle activationNFκB-dependent signalingEffect of flavopiridolAnti-inflammatory activityArrests cell cycle progressionCell cycle activationInflammatory stimuliAnti-apoptotic genesAnti-proliferative activityCell cycle progressionDiseaseInhibits expressionCycle activationFlavopiridolCycle progressionCDK inhibitorsPotential useGrowth-arrested cellsRecent studiesRNA polymerase II activationTreatmentP-TEFb complexActivationPortal Hypertension Over the Last 25 Years: Where Did It Go?
Rosemurgy A, Raitano O, Srikumar T, Sawangkum P, Luberice K, Ryan C, Ross S. Portal Hypertension Over the Last 25 Years: Where Did It Go? Journal Of The American College Of Surgeons 2016, 222: 1164-1170. PMID: 27234633, DOI: 10.1016/j.jamcollsurg.2016.02.017.Peer-Reviewed Original ResearchConceptsPercentage of patientsPortal hypertensionDecompressive shuntsHospital mortalityEndoscopic therapyEndoscopic treatmentNumber of patientsEsophageal varicesHealth care administrationHospital inpatientsHypertensionPatientsShuntDiagnosisCare administrationVaricesSurgeryTherapyMortalityTreatmentAdmissionInpatientsYearsSurgeonsAdministration