2017
Quantitative Assessment of Visceral Obesity and Postoperative Colon Cancer Outcomes
Ozoya O, Siegel E, Srikumar T, Bloomer A, DeRenzis A, Shibata D. Quantitative Assessment of Visceral Obesity and Postoperative Colon Cancer Outcomes. Journal Of Gastrointestinal Surgery 2017, 21: 534-542. PMID: 28101721, PMCID: PMC5560865, DOI: 10.1007/s11605-017-3362-9.Peer-Reviewed Original ResearchConceptsBody mass indexVisceral obesityPostoperative morbidityObese patientsShort-term postoperative outcomesOverall complication rateColon cancer outcomesMeasures of adiposityColon cancer patientsMetabolic comorbiditiesPostoperative complicationsComplication ratePostoperative outcomesVisceral adipositySurgical morbidityMass indexRisk stratificationRetrospective studyCancer outcomesCancer patientsTomography assessmentPreoperative CTMortality rateStage IColon cancer
2016
Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers
Kothari N, Teer J, Abbott A, Srikumar T, Zhang Y, Yoder S, Brohl A, Kim R, Reed D, Shibata D. Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers. Cancer 2016, 122: 2828-2835. PMID: 27244218, PMCID: PMC5014625, DOI: 10.1002/cncr.30082.Peer-Reviewed Original ResearchConceptsColorectal cancerYounger patientsExome sequencingOutcomes of patientsSporadic colorectal cancerUnique genetic alterationsFisher's exact testCRC data setsWhole-exome sequencingWorse survivalRetrospective studyTreatment modalitiesBRAF mutationsPatientsExact testFBXW7 geneLarger studyOlder agePatient samplesCohortFinal analysisSporadic cancersStatistical significanceGenetic alterationsFuture screening