2018
Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation
Zwick RK, Rudolph MC, Shook BA, Holtrup B, Roth E, Lei V, Van Keymeulen A, Seewaldt V, Kwei S, Wysolmerski J, Rodeheffer MS, Horsley V. Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation. Nature Communications 2018, 9: 3592. PMID: 30181538, PMCID: PMC6123393, DOI: 10.1038/s41467-018-05911-0.Peer-Reviewed Original ResearchConceptsMouse mammary glandMilk-producing epithelial cellsTissue-specific rolesMammary glandAdipose growthLipid dynamicsGenetic tracingPhysiological examplesFunctional implicationsCellular mechanismsAdipocyte hypertrophyMature adipocytesEssential roleVivo analysisTissue functionMammary epitheliumAdipocytesEpithelial cellsAdipocyte precursorsSubsequent involutionMilk lipidsPrimary mechanismMechanismLipidomicsMilk fat production
2017
Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity
Roberts NA, Adams BD, McCarthy NI, Tooze RM, Parnell SM, Anderson G, Kaech SM, Horsley V. Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity. The Journal Of Immunology 2017, 199: 1250-1260. PMID: 28701508, PMCID: PMC5544928, DOI: 10.4049/jimmunol.1600941.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAutoantibodiesAutoimmunityEpithelial CellsForkhead Transcription FactorsGene Expression RegulationKeratin-14Lymphocyte ActivationMiceMice, Inbred C57BLMice, NudePositive Regulatory Domain I-Binding Factor 1Thymus GlandT-LymphocytesT-Lymphocytes, RegulatoryTranscription FactorsConceptsThymic epithelial cellsThymic epithelial functionT cellsSelf-reactive T cellsEpithelial functionRegulatory T cell developmentDevelopment of Foxp3Tissue-specific AgsMouse thymic epithelial cellsRegulatory T cellsMedullary thymic epithelial cellsAnti-nuclear AbsCell type-specific deletionT cell developmentDendritic cellsAutoantibody productionAutoimmune diseasesAutoimmune pathologyNude miceAutoimmunityTEC functionConditional deletionCrucial transcription factorMiceEpithelial cells
2015
Origin of fibrosing cells in systemic sclerosis
Ebmeier S, Horsley V. Origin of fibrosing cells in systemic sclerosis. Current Opinion In Rheumatology 2015, 27: 555-562. PMID: 26352735, PMCID: PMC4639394, DOI: 10.1097/bor.0000000000000217.Peer-Reviewed Original ResearchConceptsSystemic sclerosisEndothelial cellsInjury-induced fibrosisEpithelial cellsProgressive fibrosisAutoimmune diseasesTreatment optionsEffective therapyInjury modelFibrosis modelChronic natureAnimal modelsTissue stromaSclerosisCell originFibrosisUnknown originVariety of tissuesCellular originRecent evidenceFibrocytesDiseasePericytesSpecific organsAdipocytes
2014
Chapter Four Epithelial Stem Cells in Adult Skin
Tadeu AM, Horsley V. Chapter Four Epithelial Stem Cells in Adult Skin. Current Topics In Developmental Biology 2014, 107: 109-131. PMID: 24439804, PMCID: PMC5595246, DOI: 10.1016/b978-0-12-416022-4.00004-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultCarcinoma, Basal CellCellular MicroenvironmentEpithelial CellsExocrine GlandsHumansModels, BiologicalSkinStem CellsConceptsAdult skin epitheliumTissue-specific stem cellsDifferent stem cell populationsStem cellsStem cell nicheNormal skin homeostasisStem cell populationStem cell activityCell nicheEpithelial stem cellsSkin homeostasisAbnormal regulationCell populationsAdult skinSkin epitheliumExtrinsic componentsEnvironmental aggressionsCellsNicheAdult lifeHomeostasisFirst lineRegulationRecent effortsCell activity
2007
Epithelial Stem Cells: Turning over New Leaves
Blanpain C, Horsley V, Fuchs E. Epithelial Stem Cells: Turning over New Leaves. Cell 2007, 128: 445-458. PMID: 17289566, PMCID: PMC2408375, DOI: 10.1016/j.cell.2007.01.014.Peer-Reviewed Original ResearchConceptsEpithelial stem cell maintenanceStem cell maintenanceEpithelial stem cell biologyStem cell biologyStem cellsUnipotent progenitor cellsCommon signaling pathwaysEpithelial-mesenchymal interactionsMultipotent stem cellsMost epithelial tissuesLineage determinationCell maintenanceCell biologyNew leavesEpithelial stem cellsSignaling pathwaysHuman disordersHuman diseasesFunctional differencesProgenitor cellsEpithelial tissuesRegenerative medicineMajor clinical implicationsPathwayCells
2006
Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland
Horsley V, O'Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, Nussenzweig M, Tarakhovsky A, Fuchs E. Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland. Cell 2006, 126: 597-609. PMID: 16901790, PMCID: PMC2424190, DOI: 10.1016/j.cell.2006.06.048.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBromodeoxyuridineCell CountCell DifferentiationCell LineageCell MovementCell ProliferationCells, CulturedEpithelial CellsGene Expression Regulation, DevelopmentalHair FollicleHyperplasiaMiceMice, KnockoutMice, TransgenicMultipotent Stem CellsPositive Regulatory Domain I-Binding Factor 1Proto-Oncogene Proteins c-mycRepressor ProteinsSebaceous GlandsStem CellsTranscription FactorsConceptsMultipotent stem cellsCellular inputsGenetic lineage tracingStem cellsUnipotent progenitor cellsTranscriptional repressor Blimp1Stem cell activityElevated c-myc expressionLineage commitmentC-myc expressionBrdU-labeling experimentsLineage tracingProgenitor populationsLineagesBlimp1Progenitor cellsCell proliferationLabeling experimentsSebaceous glandsCellsCell culture studiesSG homeostasisHair folliclesHomeostasisGland