2013
Chronic Tamoxifen Use Is Associated with a Decreased Risk of Intestinal Metaplasia in Human Gastric Epithelium
Moon CM, Kim SH, Lee SK, Hyeon J, Koo JS, Lee S, Wang JS, Huh WJ, Khurana SS, Mills JC. Chronic Tamoxifen Use Is Associated with a Decreased Risk of Intestinal Metaplasia in Human Gastric Epithelium. Digestive Diseases And Sciences 2013, 59: 1244-1254. PMID: 24368421, PMCID: PMC4035390, DOI: 10.1007/s10620-013-2994-1.Peer-Reviewed Original ResearchConceptsRisk of IMTamoxifen useEndoscopic gastroduodenoscopyDecreased riskGastric cancerFemale breast cancer patientsMultivariate logistic regression analysisHuman stomachHelicobacter pylori positivityBreast cancer patientsEffect of tamoxifenLogistic regression analysisHuman gastric epitheliumClinical characteristicsPylori positivityHistopathological findingsIntestinal metaplasiaPredictive factorsSydney classificationBreast surgeryCancer patientsGastric biopsiesPremalignant lesionsEstrogen exposureBiopsy site
2010
The Transcription Factor MIST1 Is a Novel Human Gastric Chief Cell Marker Whose Expression Is Lost in Metaplasia, Dysplasia, and Carcinoma
Lennerz JK, Kim SH, Oates EL, Huh WJ, Doherty JM, Tian X, Bredemeyer AJ, Goldenring JR, Lauwers GY, Shin YK, Mills JC. The Transcription Factor MIST1 Is a Novel Human Gastric Chief Cell Marker Whose Expression Is Lost in Metaplasia, Dysplasia, and Carcinoma. American Journal Of Pathology 2010, 177: 1514-1533. PMID: 20709804, PMCID: PMC2928982, DOI: 10.2353/ajpath.2010.100328.Peer-Reviewed Original ResearchConceptsChief cellsTranscription factor MIST1Gastric carcinogenesisMIST1 expressionSimilar progressive lossChief cell lineagesNormal oxyntic mucosaHuman gastric carcinogenesisHuman chief cellsChief cell markersIntestinal metaplasiaCell carcinomaMetaplastic lesionsResection specimensGastric adenocarcinomaPrecursor lesionsOxyntic mucosaTissue microarrayMetaplasiaMurine dataReliable markerTFF2 expressionHuman lesionsCell markersComparison of findings