2024
Arsenic and young liver: a case report of hepatic steatosis due to arsenic toxicity
Nguyen C, Alvarado M, Huh W, Batisti J. Arsenic and young liver: a case report of hepatic steatosis due to arsenic toxicity. Clinical Journal Of Gastroenterology 2024, 1-5. PMID: 39377877, DOI: 10.1007/s12328-024-02045-3.Peer-Reviewed Original ResearchPD-1H/VISTA Agonism Inhibits Host Myeloid Antigen Presenting Cells That Suppresses Acute Graft-Versus-Host Disease without Losing Graft-Versus-Leukemia Effect
Hu Q, Fielder C, Huh W, Kassim A, Kim T. PD-1H/VISTA Agonism Inhibits Host Myeloid Antigen Presenting Cells That Suppresses Acute Graft-Versus-Host Disease without Losing Graft-Versus-Leukemia Effect. Transplantation And Cellular Therapy 2024, 30: s253. DOI: 10.1016/j.jtct.2023.12.336.Peer-Reviewed Original ResearchMyeloid antigen-presenting cellsHost antigen-presenting cellsAntigen-presenting cellsBone marrow transplantationMyeloid-derived suppressor cellsAllogeneic T cell proliferationAcute GVHDAcute GVHD symptomsGraft-versus-leukemiaPD-1HT cell proliferationHost miceT cellsBMT modelIsotype controlGraft-versus-leukemia (GVLSuppress acute graft-versus-host diseaseMHC-mismatched bone marrow transplantationAcute graft-versus-host diseaseT cell priming phaseGraft-versus-host diseaseMismatched bone marrow transplantationMyeloid antigen presenting cellsAcute GVHD treatmentDonor T cells
2023
VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis.
Kim S, Adams T, Hu Q, Shin H, Chae G, Lee S, Sharma L, Kwon H, Lee F, Park H, Huh W, Manning E, Kaminski N, Sauler M, Chen L, Song J, Kim T, Kang M. VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2023, 69: 22-33. PMID: 36450109, PMCID: PMC10324045, DOI: 10.1165/rcmb.2022-0219oc.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisImmune regulatorsTherapeutic potentialHuman idiopathic pulmonary fibrosisCrucial immune regulatorsNovel immune regulatorPulmonary fibrosis micePulmonary fibrosis modelNovel therapeutic targetRole of VISTAWild-type littermatesMonocyte-derived macrophagesT lymphocyte lineageVISTA expressionIPF treatmentAntibody treatmentImmune landscapeFibrotic mediatorsLung fibrosisFibrosis miceInflammatory responseFibrosis modelMyeloid populationsTherapeutic targetSOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia
Willet S, Thanintorn N, McNeill H, Huh S, Ornitz D, Huh W, Hoft S, DiPaolo R, Mills J. SOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia. Cellular And Molecular Gastroenterology And Hepatology 2023, 16: 325-339. PMID: 37270061, PMCID: PMC10444955, DOI: 10.1016/j.jcmgh.2023.05.009.Peer-Reviewed Original ResearchConceptsSRY-box transcription factor 9Cell identityAdult homeostasisGastric progenitorsMucous neck cellsZymogenic chief cellsGastric developmentNeck cellsPotential genesMaster regulatorExpression patternsGene expressionSPEM cellsCell differentiationCorpus unitsSOX9 expressionSOX9Factor 9Specific expansionHomeostasisMisexpressionSox9 deletionReprogrammingChief cellsGenetic deletionIntra-Abdominal Cystic Lymphangiomas: The Vanderbilt Experience
Mede A, Chotai P, Huh W, Tan M. Intra-Abdominal Cystic Lymphangiomas: The Vanderbilt Experience. Journal Of Surgical Research 2023, 285: 197-204. PMID: 36696706, DOI: 10.1016/j.jss.2022.12.026.Peer-Reviewed Case Reports and Technical NotesConceptsAbdominal lymphangiomaSmall bowelExtensive local invasionTime of diagnosisDiagnosis of lymphangiomaInstitutional review boardVanderbilt experienceAbdominal painMultivisceral resectionMedian durationMost patientsClinical featuresFavorable prognosisRetrospective reviewCystic tumorHistopathologic characteristicsInstitution experienceSurgical excisionSymptomatic lesionsMean ageMural nodulesPreoperative imagingRare pathologyExcisional biopsyIncomplete excision
2021
Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps
Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell 2021, 184: 6262-6280.e26. PMID: 34910928, PMCID: PMC8941949, DOI: 10.1016/j.cell.2021.11.031.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAdenomaAdultAgedAnimalsCarcinogenesisCell DeathCell DifferentiationColonic PolypsColorectal NeoplasmsDisease ProgressionFemaleGene Expression Regulation, NeoplasticGene Regulatory NetworksGenetic HeterogeneityHumansMaleMiceMiddle AgedMutationNeoplastic Stem CellsReproducibility of ResultsRNA-SeqSingle-Cell AnalysisTumor MicroenvironmentConceptsHuman colorectal polypsColorectal cancerColorectal polypsPrevention of CRCMicrosatellite-unstable colorectal cancersUnstable colorectal cancersGastric metaplasiaImmune microenvironmentTumor cell differentiation statusImmune cellsPrecision surveillancePrecursor polypsSerrated polypsConventional adenomasStem cell propertiesMalignant progressionImmunogenic potentialPolypsTumor cellsTherapeutic insightsCell differentiation statusCellular originMetaplasiaAdenomasMolecular heterogeneitySupermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ. Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets. Nature Cell Biology 2021, 23: 1240-1254. PMID: 34887515, PMCID: PMC8656144, DOI: 10.1038/s41556-021-00805-8.Peer-Reviewed Original ResearchConceptsSmall extracellular vesiclesTherapeutic targetExtracellular vesiclesHepatic lipidsCardiovascular diseaseCetuximab resistanceMultiple cancersAlzheimer's diseaseDiseaseLactate secretionDisease biomarkersBiomarkersExtracellular RNAIntense investigationHuman diseasesGreater uptakeVivoCancerSecretionCell-Autonomous Role of EGFR in Spontaneous Duodenal Tumors in LRIG1 Null Mice
Niitsu H, Lu Y, Huh W, Love A, Franklin J, Coffey R. Cell-Autonomous Role of EGFR in Spontaneous Duodenal Tumors in LRIG1 Null Mice. Cellular And Molecular Gastroenterology And Hepatology 2021, 12: 1159-1162.e4. PMID: 33989815, PMCID: PMC8413138, DOI: 10.1016/j.jcmgh.2021.05.004.Peer-Reviewed Original Research
2020
A smooth muscle‐derived, Braf‐driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell‐of‐origin
Kondo J, Huh WJ, Franklin JL, Heinrich MC, Rubin BP, Coffey RJ. A smooth muscle‐derived, Braf‐driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell‐of‐origin. The Journal Of Pathology 2020, 252: 441-450. PMID: 32944951, PMCID: PMC7802691, DOI: 10.1002/path.5552.Peer-Reviewed Original ResearchConceptsGastrointestinal stromal tumorsSmooth muscle cellsICC hyperplasiaMuscle cellsTyrosine kinase inhibitor imatinibFrequent driver eventsCommon mesenchymal tumorsSmooth muscle cell progenitorsDevelopment of GISTsKinase inhibitor imatinibLoss of Trp53ICC-DMPGut motilityStromal tumorsMesenchymal tumorsMouse modelInhibitor imatinibInterstitial cellsMutant BRAFBRAF expressionTumorsBRAFHyperplasiaCell progenitorsDriver eventsKey histopathologic features in idiopathic noncirrhotic portal hypertension: an interobserver agreement study and proposal for diagnostic criteria
Liang J, Shi C, Dupont WD, Salaria SN, Huh WJ, Correa H, Roland JT, Perri RE, Washington MK. Key histopathologic features in idiopathic noncirrhotic portal hypertension: an interobserver agreement study and proposal for diagnostic criteria. Modern Pathology 2020, 34: 592-602. PMID: 32958831, DOI: 10.1038/s41379-020-00676-8.Peer-Reviewed Original ResearchConceptsIdiopathic noncirrhotic portal hypertensionObliterative portal venopathyNoncirrhotic portal hypertensionPortal hypertensionLiver biopsyDiagnostic criteriaInterobserver agreement studyHistologic featuresHistopathologic diagnostic criteriaOriginal pathologic diagnosisPractical diagnostic criteriaAgreement studyKey histopathologicPortal venopathyVein sclerosisHistologic predictorsClinicopathologic correlationHistologic diagnosisPathologic diagnosisHistologic assessmentExperienced hepatopathologistsClinical informationHypertensionBiopsyThree-tiered classificationNoggin regulates foregut progenitor cell programming and mis-expression leads to esophageal atresia
Pinzon-Guzman C, Sangadala S, Riera KM, Popova EY, Manning E, Huh WJ, Alexander MS, Shelton JS, Boden SD, Goldenring JR. Noggin regulates foregut progenitor cell programming and mis-expression leads to esophageal atresia. Journal Of Clinical Investigation 2020, 130: 4396-4410. PMID: 32427591, PMCID: PMC7410075, DOI: 10.1172/jci123597.Peer-Reviewed Original ResearchIdentification and Characterization of Unique Neutralizing Antibodies to Mouse EGF Receptor.
Jae Huh W, Niitsu H, Carney B, McKinley ET, Houghton JL, Coffey RJ. Identification and Characterization of Unique Neutralizing Antibodies to Mouse EGF Receptor. Gastroenterology 2020, 158: 1500-1502. PMID: 31866246, PMCID: PMC7103561, DOI: 10.1053/j.gastro.2019.12.017.Peer-Reviewed Original ResearchDistribution of duodenal tuft cells is altered in pediatric patients with acute and chronic enteropathy
Huh WJ, Roland JT, Asai M, Kaji I. Distribution of duodenal tuft cells is altered in pediatric patients with acute and chronic enteropathy. Biomedical Research 2020, 41: 113-118. PMID: 32307399, PMCID: PMC10037909, DOI: 10.2220/biomedres.41.113.Peer-Reviewed Original ResearchConceptsTuft cell numbersIntestinal tuft cellsTuft cellsAcute duodenitisPediatric patientsCeliac diseaseAge-matched normal controlsDouble-blind conditionsCell numberDuodenal ulcerSevere inflammationMucosal integrityPathological diagnosisDuodenal mucosaNormal controlsPathological specimensUseful markerInflammationNormal tissuesPatientsHuman intestineClinical interestPathological conditionsDuodenitisUlcersThe Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution
Rozenblatt-Rosen O, Regev A, Oberdoerffer P, Nawy T, Hupalowska A, Rood J, Ashenberg O, Cerami E, Coffey R, Demir E, Ding L, Esplin E, Ford J, Goecks J, Ghosh S, Gray J, Guinney J, Hanlon S, Hughes S, Hwang E, Iacobuzio-Donahue C, Jané-Valbuena J, Johnson B, Lau K, Lively T, Mazzilli S, Pe’er D, Santagata S, Shalek A, Schapiro D, Snyder M, Sorger P, Spira A, Srivastava S, Tan K, West R, Williams E, Network H, Aberle D, Achilefu S, Ademuyiwa F, Adey A, Aft R, Agarwal R, Aguilar R, Alikarami F, Allaj V, Amos C, Anders R, Angelo M, Anton K, Ashenberg O, Aster J, Babur O, Bahmani A, Balsubramani A, Barrett D, Beane J, Bender D, Bernt K, Berry L, Betts C, Bletz J, Blise K, Boire A, Boland G, Borowsky A, Bosse K, Bott M, Boyden E, Brooks J, Bueno R, Burlingame E, Cai Q, Campbell J, Caravan W, Cerami E, Chaib H, Chan J, Chang Y, Chatterjee D, Chaudhary O, Chen A, Chen B, Chen C, Chen C, Chen F, Chen Y, Chheda M, Chin K, Chiu R, Chu S, Chuaqui R, Chun J, Cisneros L, Coffey R, Colditz G, Cole K, Collins N, Contrepois K, Coussens L, Creason A, Crichton D, Curtis C, Davidsen T, Davies S, de Bruijn I, Dellostritto L, De Marzo A, Demir E, DeNardo D, Diep D, Ding L, Diskin S, Doan X, Drewes J, Dubinett S, Dyer M, Egger J, Eng J, Engelhardt B, Erwin G, Esplin E, Esserman L, Felmeister A, Feiler H, Fields R, Fisher S, Flaherty K, Flournoy J, Ford J, Fortunato A, Frangieh A, Frye J, Fulton R, Galipeau D, Gan S, Gao J, Gao L, Gao P, Gao V, Geiger T, George A, Getz G, Ghosh S, Giannakis M, Gibbs D, Gillanders W, Goecks J, Goedegebuure S, Gould A, Gowers K, Gray J, Greenleaf W, Gresham J, Guerriero J, Guha T, Guimaraes A, Guinney J, Gutman D, Hacohen N, Hanlon S, Hansen C, Harismendy O, Harris K, Hata A, Hayashi A, Heiser C, Helvie K, Herndon J, Hirst G, Hodi F, Hollmann T, Horning A, Hsieh J, Hughes S, Huh W, Hunger S, Hwang S, Iacobuzio-Donahue C, Ijaz H, Izar B, Jacobson C, Janes S, Jané-Valbuena J, Jayasinghe R, Jiang L, Johnson B, Johnson B, Ju T, Kadara H, Kaestner K, Kagan J, Kalinke L, Keith R, Khan A, Kibbe W, Kim A, Kim E, Kim J, Kolodzie A, Kopytra M, Kotler E, Krueger R, Krysan K, Kundaje A, Ladabaum U, Lake B, Lam H, Laquindanum R, Lau K, Laughney A, Lee H, Lenburg M, Leonard C, Leshchiner I, Levy R, Li J, Lian C, Lim K, Lin J, Lin Y, Liu Q, Liu R, Lively T, Longabaugh W, Longacre T, X. C, Macedonia M, Madison T, Maher C, Maitra A, Makinen N, Makowski D, Maley C, Maliga Z, Mallo D, Maris J, Markham N, Marks J, Martinez D, Mashl R, Masilionais I, Mason J, Massagué J, Massion P, Mattar M, Mazurchuk R, Mazutis L, Mazzilli S, McKinley E, McMichael J, Merrick D, Meyerson M, Miessner J, Mills G, Mills M, Mondal S, Mori M, Mori Y, Moses E, Mosse Y, Muhlich J, Murphy G, Navin N, Nawy T, Nederlof M, Ness R, Nevins S, Nikolov M, Nirmal A, Nolan G, Novikov E, Oberdoerffer P, O’Connell B, Offin M, Oh S, Olson A, Ooms A, Ossandon M, Owzar K, Parmar S, Patel T, Patti G, Pe’er D, Pe'er I, Peng T, Persson D, Petty M, Pfister H, Polyak K, Pourfarhangi K, Puram S, Qiu Q, Quintanal-Villalonga Á, Raj A, Ramirez-Solano M, Rashid R, Reeb A, Regev A, Reid M, Resnick A, Reynolds S, Riesterer J, Rodig S, Roland J, Rosenfield S, Rotem A, Roy S, Rozenblatt-Rosen O, Rudin C, Ryser M, Santagata S, Santi-Vicini M, Sato K, Schapiro D, Schrag D, Schultz N, Sears C, Sears R, Sen S, Sen T, Shalek A, Sheng J, Sheng Q, Shoghi K, Shrubsole M, Shyr Y, Sibley A, Siex K, Simmons A, Singer D, Sivagnanam S, Slyper M, Snyder M, Sokolov A, Song S, Sorger P, Southard-Smith A, Spira A, Srivastava S, Stein J, Storm P, Stover E, Strand S, Su T, Sudar D, Sullivan R, Surrey L, Suvà M, Tan K, Terekhanova N, Ternes L, Thammavong L, Thibault G, Thomas G, Thorsson V, Todres E, Tran L, Tyler M, Uzun Y, Vachani A, Van Allen E, Vandekar S, Veis D, Vigneau S, Vossough A, Waanders A, Wagle N, Wang L, Wendl M, West R, Williams E, Wu C, Wu H, Wu H, Wyczalkowski M, Xie Y, Yang X, Yapp C, Yu W, Yuan Y, Zhang D, Zhang K, Zhang M, Zhang N, Zhang Y, Zhao Y, Zhou D, Zhou Z, Zhu H, Zhu Q, Zhu X, Zhu Y, Zhuang X. The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution. Cell 2020, 181: 236-249. PMID: 32302568, PMCID: PMC7376497, DOI: 10.1016/j.cell.2020.03.053.Commentaries, Editorials and LettersConceptsSingle-cell genomic technologiesSingle-cell resolutionDynamic tumor ecosystemRelevant cell typesGenomic approachesCell statesGenomic technologiesTumor ecosystemBulk sequencingThree-dimensional atlasesCancer biologyCell typesCellular interactionsTumor initiationUnprecedented resolutionTumor transitionTherapeutic discoveryDiverse setCancer transitionComplex interactionsPrecision medicine treatmentBiologyCrucial transitionEcosystemsSequencing
2019
Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress
Byrd KM, Piehl NC, Patel JH, Huh WJ, Sequeira I, Lough KJ, Wagner BL, Marangoni P, Watt FM, Klein OD, Coffey RJ, Williams SE. Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress. Cell Stem Cell 2019, 25: 814-829.e6. PMID: 31809739, PMCID: PMC6925542, DOI: 10.1016/j.stem.2019.11.005.Peer-Reviewed Original ResearchConceptsStem cell populationJunctional zoneOral mucosaStem cellsImportant model systemCell populationsEpithelial stem cell populationSingle-progenitor modelAsymmetric divisionLabel-retention assaysCandidate nichesSymmetric divisionTissue stressOral cavityPalatal epitheliumPhysiological stressModel systemStratified epitheliumMucosaProliferative heterogeneityEpitheliumLinking ALDH1 and retinoic acid signaling
Markham NO, Huh WJ, Coffey RJ. Linking ALDH1 and retinoic acid signaling. Oncotarget 2019, 10: 1226-1227. PMID: 30815222, PMCID: PMC6383818, DOI: 10.18632/oncotarget.26661.Commentaries, Editorials and Letters
2017
A Chimeric Egfr Protein Reporter Mouse Reveals Egfr Localization and Trafficking In Vivo
Yang YP, Ma H, Starchenko A, Huh WJ, Li W, Hickman FE, Zhang Q, Franklin JL, Mortlock DP, Fuhrmann S, Carter BD, Ihrie RA, Coffey RJ. A Chimeric Egfr Protein Reporter Mouse Reveals Egfr Localization and Trafficking In Vivo. Cell Reports 2017, 19: 1257-1267. PMID: 28494873, PMCID: PMC5517093, DOI: 10.1016/j.celrep.2017.04.048.Peer-Reviewed Original ResearchConceptsEGF receptorEGFR localizationEndogenous regulatory elementsDistinct cell populationsReporter miceGenome editingEGFR internalizationRegulatory elementsCRISPR/C-terminusEndogenous EGFRFluorescent reportersDifferentiated compartmentVillus compartmentTraffickingCell populationsReporterExpressionEGFR expressionDisease statesDistinct patternsCompartmentsAdjacent epitheliumIntestinal tumorsAdult miceIn liver metastases from small intestinal neuroendocrine tumors, SSTR2A expression is heterogeneous
Charoenpitakchai M, Liu E, Zhao Z, Koyama T, Huh WJ, Berlin J, Hande K, Walker R, Shi C. In liver metastases from small intestinal neuroendocrine tumors, SSTR2A expression is heterogeneous. Virchows Archiv 2017, 470: 545-552. PMID: 28213807, PMCID: PMC5623953, DOI: 10.1007/s00428-017-2093-3.Peer-Reviewed Original ResearchConceptsSmall intestinal neuroendocrine tumorsLiver metastasesSSTR2A expressionIntestinal neuroendocrine tumorsKi67 indexNeuroendocrine tumorsPrimary tumorLiver tumorsMetastatic small intestinal neuroendocrine tumorsMore liver lesionsMost liver tumorsCorresponding liver metastasesMore liver tumorsFormalin-fixed paraffin-embedded sectionsParaffin-embedded sectionsMetastatic lesionsMetastatic tumorsSI-NETsSame patientLiver lesionsIHC scoreMetastasisScoring systemSignificant associationTumor tissue
2016
Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial–mesenchymal transition
Gonzalez RS, Huh WJ, Cates JM, Washington K, Beauchamp RD, Coffey RJ, Shi C. Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial–mesenchymal transition. Histopathology 2016, 70: 223-231. PMID: 27560620, PMCID: PMC5921077, DOI: 10.1111/his.13068.Peer-Reviewed Original ResearchConceptsEpithelial-mesenchymal transitionColorectal carcinomaDistant metastasisImmunohistochemical evidenceEvidence of EMTAdvanced T categoryConventional colorectal carcinomaCystic nodal metastasisStage IV diseaseAdvanced local diseaseLymph node metastasisMicrosatellite instability testingBRAF V600E mutationMedian survivalMucinous featuresOverall survivalNodal metastasisNode metastasisLocal diseaseMicropapillary featuresT categoryDirty necrosisCribriform patternKRAS mutationsProminent necrosisThe Spectrum of Histologic Findings in Hepatic Outflow Obstruction
Gonzalez RS, Gilger MA, Huh WJ, Washington MK. The Spectrum of Histologic Findings in Hepatic Outflow Obstruction. Archives Of Pathology & Laboratory Medicine 2016, 141: 98-103. PMID: 27681331, PMCID: PMC6420777, DOI: 10.5858/arpa.2015-0388-oa.Peer-Reviewed Original ResearchConceptsHepatic outflow obstructionPortal tract changesCardiac hepatopathyBudd-Chiari syndromeOutflow obstructionHistologic findingsBudd-ChiariSinusoidal fibrosisSinusoidal dilationTract changesCentral veinHepatic venous outflow obstructionVenous outflow obstructionBile ductular reactionDistinctive histologic findingsHepatocyte dropoutDifferent pathophysiologyPrior diagnosisChronic inflammationCentrilobular necrosisDuctular reactionMorphologic findingsUndiagnosed patientsChronic natureHepatopathy