2016
Candidate predisposing germline copy number variants in early onset colorectal cancer patients
Brea-Fernandez AJ, Fernandez-Rozadilla C, Alvarez-Barona M, Azuara D, Ginesta MM, Clofent J, de Castro L, Gonzalez D, Andreu M, Bessa X, Llor X, Xicola R, Jover R, Castells A, Castellvi-Bel S, Capella G, Carracedo A, Ruiz-Ponte C. Candidate predisposing germline copy number variants in early onset colorectal cancer patients. Clinical And Translational Oncology 2016, 19: 625-632. PMID: 27888432, DOI: 10.1007/s12094-016-1576-z.Peer-Reviewed Original ResearchMeSH KeywordsAge of OnsetColorectal NeoplasmsDNA Copy Number VariationsDNA MethylationDNA Mutational AnalysisGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansIntercellular Signaling Peptides and ProteinsLoss of HeterozygosityNerve Tissue ProteinsReal-Time Polymerase Chain ReactionConceptsColorectal cancerEarly-onset colorectal cancer patientsEarly-onset CRC patientsMethods/patientsWeColorectal cancer patientsHereditary colorectal cancerIdentifiable germline mutationsCopy number variantsPenetrant copy number variantsSomatic mutation analysisCRC patientsGenome-wide copy number analysisCancer patientsReal-time quantitative PCRMultiplex ligation probe amplificationCRC tumorsColorectal carcinogenesisLoss of heterozygosityPatientsSLIT2 geneGenetic susceptibilityDuplex real-time quantitative PCREarly onsetGermline mutationsConclusionsThese findings
2012
Defectos de la metilación del ADN en el cáncer colorrectal esporádico y hereditario
Xicola RM, Llor X. Defectos de la metilación del ADN en el cáncer colorrectal esporádico y hereditario. Gastroenterología Y Hepatología 2012, 35: 480-487. PMID: 22459641, DOI: 10.1016/j.gastrohep.2012.01.010.BooksMeSH KeywordsAdenocarcinomaAdenomaAnticarcinogenic AgentsAntineoplastic AgentsBiomarkersCell Transformation, NeoplasticClonal EvolutionColorectal NeoplasmsCpG IslandsDietDNA MethylationDNA, NeoplasmDrug DesignFolic AcidGenes, NeoplasmGenes, Tumor SuppressorGenome-Wide Association StudyHumansIncidenceMolecular Targeted TherapyMutationNeoplastic Syndromes, HereditaryPolyphenolsSeleniumConceptsMethylation defectsFundamental epigenetic mechanismCrucial cell functionsExpression of genesEpigenetic mechanismsDNA methylationGene analysisMethylationMethylation processCancer developmentCell functionDevelopment of chemotherapyEffect of dietGenesColorectal carcinogenesisAntineoplastic activity
2011
Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles
Balaguer F, Moreira L, Lozano JJ, Link A, Ramirez G, Shen Y, Cuatrecasas M, Arnold M, Meltzer SJ, Syngal S, Stoffel E, Jover R, Llor X, Castells A, Boland CR, Gironella M, Goel A. Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles. Clinical Cancer Research 2011, 17: 6239-6249. PMID: 21844009, PMCID: PMC3186834, DOI: 10.1158/1078-0432.ccr-11-1424.Peer-Reviewed Original ResearchConceptsColorectal cancerTypes of MSIMicrosatellite instabilityMiRNA expression profilesUnique miRNA profileCRC tissuesNormal colonic mucosa tissuesSporadic MSI tumorsColonic mucosa tissuesMSS colorectal cancerLynch syndrome tumorsNormal colonic mucosaSporadic microsatellite instabilityMiRNA profilesMSI-positive samplesNormal colonic tissueUnique miRNA expression profilesExpression profilesQuantitative reverse transcriptase PCRReverse transcriptase-PCRDistinct miRNA expression profilesColonic mucosaLynch syndromeColonic tissueColorectal carcinogenesis
2009
S1271 Plantago Ovata Husk Regulates Cell Cycle Progression and Wnt Signaling Pathway, Crucial Elements Implicated in Colorectal Carcinogenesis
Sapoznik V, Grzybowski M, Xicola R, Doyle B, Grzybowski J, Martinez T, Anguera A, Llor X. S1271 Plantago Ovata Husk Regulates Cell Cycle Progression and Wnt Signaling Pathway, Crucial Elements Implicated in Colorectal Carcinogenesis. Gastroenterology 2009, 136: a-226. DOI: 10.1016/s0016-5085(09)61020-9.Peer-Reviewed Original Research
2003
The effects of fish oil, olive oil, oleic acid and linoleic acid on colorectal neoplastic processes
LLOR X, PONS E, ROCA A, ÀLVAREZ M, MAÑÉ J, FERNÁNDEZ-BAÑARES F, GASSULL MA. The effects of fish oil, olive oil, oleic acid and linoleic acid on colorectal neoplastic processes. Clinical Nutrition 2003, 22: 71-79. PMID: 12553953, DOI: 10.1054/clnu.2002.0627.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisCaco-2 CellsCells, CulturedCyclooxygenase 2Fish OilsGenes, bcl-2HT29 CellsHumansIsoenzymesKeratin-8KeratinsLinoleic AcidMembrane ProteinsMicroscopy, FluorescenceOleic AcidOlive OilPlant OilsProstaglandin-Endoperoxide SynthasesReverse Transcriptase Polymerase Chain ReactionSucrase-Isomaltase ComplexThymidineConceptsColorectal cancer developmentCOX-2Bcl-2 expressionFish oilCancer developmentHT-29 colorectal cancer cellsCell proliferationLinoleic acidColorectal cancer cellsMain dietary sourceFatty acidsLate effectsColorectal carcinogenesisAntineoplastic effectsNeoplastic processInduction of apoptosisEarly downregulationImportant mediatorOlive oilCancer cellsCaco-2Dietary sourcesBcl-2Different fatsApoptosis induction