PLCÎł1 promotes phase separation of T cell signaling components
Zeng L, Palaia I, Ć ariÄ A, Su X. PLCÎł1 promotes phase separation of T cell signaling components. Journal Of Cell Biology 2021, 220: e202009154. PMID: 33929486, PMCID: PMC8094118, DOI: 10.1083/jcb.202009154.Peer-Reviewed Original ResearchConceptsTCR signal transductionT-cell receptor pathwayLiquid-like condensatesKey adaptor proteinLAT clusteringLAT complexSH2 domainAdaptor proteinPhosphatase CD45Signal transductionTCR pathwayPhospholipase CÎł1ERK activationProtein compositionBiophysical principlesPLCÎł1Critical functionsReceptor pathwayPathwayLATMajor componentT cellsCellsActivationDephosphorylation