2024
The Influence of DNA Repair Genes and Prenatal Tobacco Exposure on Risk of Childhood Acute Lymphoblastic Leukemia-A Gene-Environment Interaction Study.
Wang X, Zhong C, Ma X, Metayer C, Mancuso N, Gauderman W, Wiemels J. The Influence of DNA Repair Genes and Prenatal Tobacco Exposure on Risk of Childhood Acute Lymphoblastic Leukemia-A Gene-Environment Interaction Study. Cancer Epidemiology Biomarkers & Prevention 2024 PMID: 39495115, DOI: 10.1158/1055-9965.epi-24-1037.Peer-Reviewed Original ResearchPrenatal tobacco exposureTobacco exposureGene-environment interaction studiesNon-Latino white childrenAcute lymphoblastic leukemia riskChildhood ALL riskRepair genesGene-environment interactionsAcute lymphoblastic leukemiaStatistically significant interactionPotential risk factorsDNA repair genesTobacco smokeLatino childrenPediatric oncologyALL riskTargeted preventionWhite childrenLogistic regressionEpidemiological studiesEnvironmental exposuresRisk factorsTobaccoGenotype dataSignificant interaction
2023
Association between birth characteristics and incidence of pituitary adenoma and craniopharyngioma: a registry-based study in California, 2001–2015
Cote D, Wang R, Morimoto L, Metayer C, Zada G, Wiemels J, Ma X. Association between birth characteristics and incidence of pituitary adenoma and craniopharyngioma: a registry-based study in California, 2001–2015. Cancer Causes & Control 2023, 34: 757-768. PMID: 37225897, PMCID: PMC10363066, DOI: 10.1007/s10552-023-01718-7.Peer-Reviewed Original ResearchConceptsOlder maternal ageMultivariable logistic regressionNon-Hispanic white individualsHigher maternal educationPituitary adenomasBirth characteristicsMaternal educationSignificant associationMaternal ageOdds ratioNon-Hispanic white raceUnconditional multivariable logistic regressionLogistic regressionParental sociodemographic characteristicsRegistry-based studyPopulation-based studyWhite individualsAdjusted odds ratioEarly-onset cancersNon-Hispanic whitesBirth pluralityIncident casesBlack raceFemale sexHispanic ethnicity
2022
Unconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case–Control Study in Pennsylvania, 2009–2017
Clark CJ, Johnson NP, Soriano M, Warren JL, Sorrentino KM, Kadan-Lottick NS, Saiers JE, Ma X, Deziel NC. Unconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case–Control Study in Pennsylvania, 2009–2017. Environmental Health Perspectives 2022, 130: 087001. PMID: 35975995, PMCID: PMC9383266, DOI: 10.1289/ehp11092.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCase-control studyOdds ratioChildhood leukemiaLymphoblastic leukemiaPerinatal windowRegistry-based case-control studyChildhood acute lymphoblastic leukemiaConfidence intervalsResidential proximityChildren ages 2Risk factorsMaternal raceChild healthExposure windowsSocio-economic statusPotential associationLeukemiaLogistic regressionAge 2Birth yearCommon formBirth residenceDevelopment exposureOdds
2021
Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia
Whitehead TP, Wiemels JL, Zhou M, Kang AY, McCoy LS, Wang R, Fitch B, Petrick LM, Yano Y, Imani P, Rappaport SM, Dahl GV, Kogan SC, Ma X, Metayer C. Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia. Cancer Epidemiology Biomarkers & Prevention 2021, 30: 1526-1535. PMID: 34078642, PMCID: PMC8338848, DOI: 10.1158/1055-9965.epi-20-1704.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCytokine levelsLymphoblastic leukemiaChildhood acute lymphoblastic leukemiaAberrant immune reactionsPrenatal immune developmentRisk of childhoodInterquartile range incrementAltered cytokine levelsCalifornia Childhood Leukemia StudyChildhood Leukemia StudyBirth characteristicsNeonatal levelsPrenatal exposureImmunomodulatory cytokinesImmune developmentHigh hyperdiploidyImmune reactionsCytokinesGM-CSFBlood spotsLogistic regressionLeukemia StudyEndogenous metabolitesConfidence intervals
2019
Association of provider experience and clinical outcomes in patients with myelodysplastic syndromes receiving hypomethylating agents
Zeidan AM, Hu X, Zhu W, Stahl M, Wang R, Huntington SF, Giri S, Bewersdorf JP, Podoltsev NA, Gore SD, Ma X, Davidoff AJ. Association of provider experience and clinical outcomes in patients with myelodysplastic syndromes receiving hypomethylating agents. Leukemia & Lymphoma 2019, 61: 397-408. PMID: 31570040, PMCID: PMC7732188, DOI: 10.1080/10428194.2019.1663423.Peer-Reviewed Original ResearchConceptsMyelodysplastic syndromeOverall survivalHMA cyclesHMA therapyProvider experienceCox proportional hazards modelOlder MDS patientsMedian overall survivalPercent of patientsSEER-Medicare dataMultivariate logistic regressionProportional hazards modelHMA initiationClinical outcomesMDS patientsClinical trialsMedian numberHMA treatmentHazards modelPatientsSignificant associationLogistic regressionPopulation-level survivalSurvivalSyndromeParental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium
Panagopoulou P, Skalkidou A, Marcotte E, Erdmann F, Ma X, Heck JE, Auvinen A, Mueller BA, Spector LG, Roman E, Metayer C, Magnani C, Pombo-de-Oliveira MS, Scheurer ME, Mora AM, Dockerty JD, Hansen J, Kang AY, Wang R, Doody DR, Kane E, Schüz J, Christodoulakis C, Ntzani E, Petridou ET, group F, group N. Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium. Cancer Epidemiology 2019, 59: 158-165. PMID: 30776582, PMCID: PMC7098424, DOI: 10.1016/j.canep.2019.01.022.Peer-Reviewed Original ResearchConceptsChildhood Leukemia International ConsortiumAcute myeloid leukemiaAML riskOdds ratioMyeloid leukemiaParental ageChildhood acute myeloid leukemiaPaternal age groupsInfants of mothersConfidence intervalsAdvanced maternal ageMultiple logistic regressionPooled-effect estimatesInfant acute myeloid leukemiaMaternal smokingMultiple gestationsMaternal ageChildhood cancerAML casesAge groupsLogistic regressionStudy designAge incrementsOlder childrenAge
2016
Birth weight and risk of paediatric Hodgkin lymphoma: Findings from a population-based record linkage study in California
Triebwasser C, Wang R, DeWan AT, Metayer C, Morimoto L, Wiemels JL, Kadan-Lottick N, Ma X. Birth weight and risk of paediatric Hodgkin lymphoma: Findings from a population-based record linkage study in California. European Journal Of Cancer 2016, 69: 19-27. PMID: 27814470, PMCID: PMC5125877, DOI: 10.1016/j.ejca.2016.09.016.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge of OnsetBirth OrderBirth WeightCaliforniaCase-Control StudiesChildChild, PreschoolEthnicityFemaleFetal MacrosomiaHodgkin DiseaseHumansInfantInfant, Low Birth WeightInfant, NewbornInformation Storage and RetrievalLogistic ModelsMaleMaternal AgeOdds RatioPaternal AgeRisk FactorsConceptsAge of diagnosisPediatric Hodgkin lymphomaHigh birth weightBirth weightTime of deliveryHodgkin's lymphomaOdds ratioPopulation-based record linkage studyPopulation-based case-control studyBirth orderNormal birth weightRecord linkage studyCase-control studyConditional logistic regressionMagnitude of associationSubgroup of childrenPerinatal factorsMaternal ageEtiological investigationBirth recordsPaternal ageHL casesDisease riskLogistic regressionDiagnosis
2015
Birth weight, fetal growth, and risk of pediatric rhabdomyosarcoma: an updated record linkage study in California
Morimoto LM, McCauley K, Ma X, Wiemels JL, Chokkalingam AP, Metayer C. Birth weight, fetal growth, and risk of pediatric rhabdomyosarcoma: an updated record linkage study in California. Annals Of Epidemiology 2015, 26: 141-145. PMID: 26795698, DOI: 10.1016/j.annepidem.2015.11.007.Peer-Reviewed Original ResearchConceptsRisk of rhabdomyosarcomaHigh birth weightBirth weightGestational ageNon-Hispanic white childrenPost-term babiesCalifornia Cancer RegistryNormal gestational ageRecord linkage studyConditional logistic regressionCalifornia birth recordsNon-Hispanic whitesIndication of associationCancer RegistryBirth characteristicsFetal growthPediatric rhabdomyosarcomaRMS casesLower riskBirth recordsEthnic groupsLarger studyLogistic regressionWhite childrenAge
2009
Dietary Meat Intake in Relation to Colorectal Adenoma in Asymptomatic Women
Ferrucci LM, Sinha R, Graubard BI, Mayne ST, Ma X, Schatzkin A, Schoenfeld PS, Cash BD, Flood A, Cross AJ. Dietary Meat Intake in Relation to Colorectal Adenoma in Asymptomatic Women. The American Journal Of Gastroenterology 2009, 104: ajg2009102. PMID: 19367270, PMCID: PMC2891034, DOI: 10.1038/ajg.2009.102.Peer-Reviewed Original ResearchMeSH KeywordsAdenomaAdultAgedColonoscopyColorectal NeoplasmsConfidence IntervalsCookingCross-Sectional StudiesDietFemaleFollow-Up StudiesHeterocyclic CompoundsHumansIncidenceLogistic ModelsMass ScreeningMeat ProductsMiddle AgedMultivariate AnalysisOdds RatioReference ValuesRisk AssessmentSeverity of Illness IndexConceptsColorectal adenomasAsymptomatic womenMeat intakeOdds ratioRed meatMeat-cooking methodsColorectal adenoma casesConfidence intervalsPan-fried meatDietary meat intakeEligible womenDoneness levelFood frequencyAdenoma casesHigh intakeAdenomasMeat mutagensLogistic regressionIntakeWomenScreening studyColonoscopyComponents of meatPositive associationFurther investigationXenobiotic Metabolizing Gene Variants, Dietary Heterocyclic Amine Intake, and Risk of Prostate Cancer
Koutros S, Berndt SI, Sinha R, Ma X, Chatterjee N, Alavanja MC, Zheng T, Huang WY, Hayes RB, Cross AJ. Xenobiotic Metabolizing Gene Variants, Dietary Heterocyclic Amine Intake, and Risk of Prostate Cancer. Cancer Research 2009, 69: 1877-1884. PMID: 19223546, PMCID: PMC2662592, DOI: 10.1158/0008-5472.can-08-2447.Peer-Reviewed Original ResearchConceptsProstate cancer riskProstate cancerOdds ratioCancer riskSingle nucleotide polymorphismsDietary Heterocyclic Amine IntakeOvarian Cancer Screening TrialHeterocyclic amine intakeCancer Screening TrialUnconditional logistic regressionCase-control studyDietary heterocyclic aminesProstate cancer casesHeterocyclic aminesHCA intakeCancer casesLow intakeScreening TrialHCA metabolismMalignant transformationLogistic regressionCancerIntakeGene variantsConfidence intervals
2008
Prevalence of polycythemia vera and essential thrombocythemia
Ma X, Vanasse G, Cartmel B, Wang Y, Selinger HA. Prevalence of polycythemia vera and essential thrombocythemia. American Journal Of Hematology 2008, 83: 359-362. PMID: 18181200, DOI: 10.1002/ajh.21129.Peer-Reviewed Original ResearchConceptsPrevalence of PVPolycythemia veraEssential thrombocythemiaMyeloproliferative disordersUS populationAge-standardized prevalenceHealth claims dataAge-specific prevalenceLarge US populationEntire US populationClaims dataET patientsInsurance payerHealth claimsLogistic regressionPrevalencePatientsMedicaid ServicesMolecular etiologyCommon typeThrombocythemiaDisordersUnited StatesAffected populationVera
2005
Maternal Pregnancy Loss, Birth Characteristics, and Childhood Leukemia (United States)
Ma X, Metayer C, Does MB, Buffler PA. Maternal Pregnancy Loss, Birth Characteristics, and Childhood Leukemia (United States). Cancer Causes & Control 2005, 16: 1075-1083. PMID: 16184473, DOI: 10.1007/s10552-005-0356-9.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, SpontaneousAdolescentBirth CertificatesBirth IntervalsBirth OrderBirth WeightCaliforniaCase-Control StudiesChildChild, PreschoolFemaleHumansInfantInfant, NewbornLeukemia, Myeloid, AcuteMalePrecursor Cell Lymphoblastic Leukemia-LymphomaPregnancyPregnancy, High-RiskRisk AssessmentRisk FactorsConceptsBirth characteristicsPregnancy lossChildhood leukemiaOdds ratioNorthern California Childhood Leukemia StudyHistory of miscarriageConfidence intervalsRisk of AMLConditional logistic regressionDetailed reproductive historyCalifornia Childhood Leukemia StudyChildhood Leukemia StudyChildhood AMLIncident casesBirth weightMaternal historyIndex childReproductive historyBirth recordsLogistic regressionRecall biasBirth certificatesLeukemia StudyAMLLeukemia