2023
H3.1K27me1 loss confers Arabidopsis resistance to Geminivirus by sequestering DNA repair proteins onto host genome
Wang Z, Castillo-González C, Zhao C, Tong C, Li C, Zhong S, Liu Z, Xie K, Zhu J, Wu Z, Peng X, Jacob Y, Michaels S, Jacobsen S, Zhang X. H3.1K27me1 loss confers Arabidopsis resistance to Geminivirus by sequestering DNA repair proteins onto host genome. Nature Communications 2023, 14: 7484. PMID: 37980416, PMCID: PMC10657422, DOI: 10.1038/s41467-023-43311-1.Peer-Reviewed Original ResearchConceptsDNA repair proteinsDNA repair pathwaysRepair pathwaysRepair proteinsWild-type plantsDefense-related genesArabidopsis resistanceHeterochromatin amplificationHeterochromatic regionsRAD51 recruitmentRep proteinGenomic instabilityHealthy plantsUnstable genomeHost genomeATXR6GeminivirusesRobust resistanceProteinViral amplificationGenomeMutantsViral DNATransposonPlants
2021
H3.1K27me1 maintains transcriptional silencing and genome stability by preventing GCN5-mediated histone acetylation
Dong J, LeBlanc C, Poulet A, Mermaz B, Villarino G, Webb KM, Joly V, Mendez J, Voigt P, Jacob Y. H3.1K27me1 maintains transcriptional silencing and genome stability by preventing GCN5-mediated histone acetylation. The Plant Cell 2021, 33: 961-979. PMID: 33793815, PMCID: PMC8226292, DOI: 10.1093/plcell/koaa027.Peer-Reviewed Original ResearchConceptsGenome stabilityGenomic instabilityHistone acetylationSAGA-like complexesMultiple lysine residuesArabidopsis GCN5ARABIDOPSIS TRITHORAXArabidopsis thalianaTranscriptional silencingHeterochromatin defectsDouble mutantDNA replicationEpigenetic mechanismsGCN5Molecular roleEssential functionsDiverse rolesMolecular mechanismsLysine residuesProtein 5AcetylationMutantsPlantsADA2bATXR6