2024
AAPM Task Group Report 267: A joint AAPM GEC‐ESTRO report on biophysical models and tools for the planning and evaluation of brachytherapy
Chen Z, Li X, Brenner D, Hellebust T, Hoskin P, Joiner M, Kirisits C, Nath R, Rivard M, Thomadsen B, Zaider M. AAPM Task Group Report 267: A joint AAPM GEC‐ESTRO report on biophysical models and tools for the planning and evaluation of brachytherapy. Medical Physics 2024, 51: 3850-3923. PMID: 38721942, DOI: 10.1002/mp.17062.Peer-Reviewed Original ResearchDose delivery patternClinical medical physicistsBrachytherapy modalitiesMedical physicistsAAPM Task Group ReportAmerican Association of PhysicsBrachytherapy treatment planningTask group reportRadioactive sourcesDevelopment of biophysical modelsEuropean Society for Radiotherapy & OncologyGEC-ESTRORadiobiological effectsAAPMRadiation oncologyBrachytherapyBiophysical modelTreatment planningPhysicistsClinical effectsClinical backgroundIrradiated tissueDelivery patternsPractice guidelinesTreatment techniques
2020
A prototype open-ended multichannel intracavitary-interstitial hybrid applicator for gynecological high-dose-rate brachytherapy
Tien CJ, Chen Z. A prototype open-ended multichannel intracavitary-interstitial hybrid applicator for gynecological high-dose-rate brachytherapy. Radiological Physics And Technology 2020, 13: 187-194. PMID: 32424632, DOI: 10.1007/s12194-020-00567-2.Peer-Reviewed Original ResearchConceptsPrescription doseRate brachytherapyHybrid applicatorPrior patientsRisk doseMinimum doseOAR D2ccMultichannel applicatorCentral tandemDoseTarget coverageInterstitial needlesPatientsApplicator bodyBrachytherapyDistal endOpen distal endsPeripheral needlesPeripheral channelsSilico studiesNeedleBowelBladderD2ccRectum
2018
Extended duration of dilator use beyond 1 year may reduce vaginal stenosis after intravaginal high-dose-rate brachytherapy
Stahl JM, Qian JM, Tien CJ, Carlson DJ, Chen Z, Ratner ES, Park HS, Damast S. Extended duration of dilator use beyond 1 year may reduce vaginal stenosis after intravaginal high-dose-rate brachytherapy. Supportive Care In Cancer 2018, 27: 1425-1433. PMID: 30187220, DOI: 10.1007/s00520-018-4441-5.Peer-Reviewed Original ResearchConceptsVaginal stenosisEndometrial carcinomaMultivariable Cox proportional hazardsMultivariable Cox regression analysisVD useAcademic tertiary referral centerTertiary referral centerCox regression analysisLog-rank testCox proportional hazardsDevelopment of gradeDilator usePelvic radiotherapyReferral centerNoncompliant patientsPrimary outcomeAdjuvant brachytherapyEC patientsConclusionsThe riskRate brachytherapyProportional hazardsOptimal durationPatientsBrachytherapyStudy period
2013
Using Skin Dose Parameters Predicts Low Skin Toxicity in a Phase 2 Trial of Multiple Dwell Position Balloon-Based Brachytherapy for Partial Breast Irradiation
Nath S, Chen Z, Rowe B, Blitzblau R, Aneja S, Grube B, Horowitz N, Weidhaas J. Using Skin Dose Parameters Predicts Low Skin Toxicity in a Phase 2 Trial of Multiple Dwell Position Balloon-Based Brachytherapy for Partial Breast Irradiation. International Journal Of Radiation Oncology • Biology • Physics 2013, 87: s213. DOI: 10.1016/j.ijrobp.2013.06.551.Peer-Reviewed Original Research
2010
Response to “Comment on ‘AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137’” [Med. Phys. 36, 5310–5322 (2009)]
Nath R, Bice WS, Butler WM, Chen Z, Meigooni AS, Narayana V, Rivard MJ, Yu Y. Response to “Comment on ‘AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137’” [Med. Phys. 36, 5310–5322 (2009)]. Medical Physics 2010, 37: 1933-1933. PMID: 20443515, DOI: 10.1118/1.3358143.Peer-Reviewed Original Research
2008
A preliminary report on AAPM guidelines on the physics of dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer
Nath R, Bice W, Butler W, Chen Z, Meigooni A, Narayana V, Rivard M, Yu Y. A preliminary report on AAPM guidelines on the physics of dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer. Brachytherapy 2008, 7: 132. DOI: 10.1016/j.brachy.2008.02.123.Peer-Reviewed Original Research
2007
On the Need to Compensate for Edema-Induced Dose Reductions in Preplanned 131Cs Prostate Brachytherapy
Chen ZJ, Deng J, Roberts K, Nath R. On the Need to Compensate for Edema-Induced Dose Reductions in Preplanned 131Cs Prostate Brachytherapy. International Journal Of Radiation Oncology • Biology • Physics 2007, 70: 303-310. PMID: 17980500, PMCID: PMC2289996, DOI: 10.1016/j.ijrobp.2007.09.007.Peer-Reviewed Original ResearchConceptsDose reductionProstate brachytherapyDose compensationLarge edemaBiochemical recurrence-free survivalRecurrence-free survivalSignificant dose reductionEffects of edemaSublethal damage repairAdditional irradiationPrescription doseProstate cancerIndividual patientsEdemaEdema evolutionPrescribed doseProstate edemaEffective doseRadiobiologic effectsBrachytherapyDoseProstate implantsDose responseImplants
2005
Dose rate dependence of the relative biological effectiveness of 103Pd for continuous low dose rate irradiation of BA1112 rhabdomyosarcoma cells in vitro relative to acute exposures
Nath R, Bongiorni P, Chen Z, Gragnano J, Rockwell S. Dose rate dependence of the relative biological effectiveness of 103Pd for continuous low dose rate irradiation of BA1112 rhabdomyosarcoma cells in vitro relative to acute exposures. International Journal Of Radiation Biology 2005, 81: 689-699. PMID: 16368647, DOI: 10.1080/09553000500401551.Peer-Reviewed Original ResearchConceptsContinuous low dose rate irradiationDose rate irradiationLow dose rate irradiationRate irradiationInterstitial brachytherapyHigh dose rate irradiationAcute exposureRhabdomyosarcoma cellsPermanent interstitial brachytherapyRelative biological effectivenessBA1112 tumorsSame dose rateSurvival curvesHigh linear energy transferAcute irradiationTumor cellsCell survival curvesBiological effectivenessLow dose rateDose-rate effectDose rateBrachytherapy