2023
Dose prescription and reporting in stereotactic body radiotherapy: A multi-institutional study
Das I, Yadav P, Andersen A, Chen Z, Huang L, Langer M, Lee C, Li L, Popple R, Rice R, Schiff P, Zhu T, Abazeed M. Dose prescription and reporting in stereotactic body radiotherapy: A multi-institutional study. Radiotherapy And Oncology 2023, 182: 109571. PMID: 36822361, PMCID: PMC10121952, DOI: 10.1016/j.radonc.2023.109571.Peer-Reviewed Original ResearchMeSH KeywordsHumansMalePrescriptionsRadiosurgeryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, Intensity-ModulatedConceptsDose prescriptionTreatment-related toxicityClinical outcome comparisonStereotactic body radiotherapyMulti-institutional studyTreatment guidelinesTreatment disparitiesBody radiotherapyPTV volumeClinical trialsTreatment protocolOutcome comparisonsTreatment efficacyAbstractTextHypofractionated treatmentDosimetric parametersDose parametersDosimetric variabilityDosimetric variationsStandardized reportingLack of standardizationPreliminary dosimetric comparison between fixed and rotating source stereotactic radiosurgery systems
Draeger E, Chen Z, Hansen J, Chiang V, Tien C. Preliminary dosimetric comparison between fixed and rotating source stereotactic radiosurgery systems. Journal Of Applied Clinical Medical Physics 2023, 24: e13907. PMID: 36660774, PMCID: PMC10161057, DOI: 10.1002/acm2.13907.Peer-Reviewed Original ResearchMeSH KeywordsBrain NeoplasmsHumansPituitary NeoplasmsRadiometryRadiosurgeryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRetrospective StudiesConceptsConformity indexRadiation Therapy Oncology Group conformity indexGK plansSuperior conformity indexNon-metastatic casesPaddick conformity indexDosimetric plan qualityGK patientsBrain metastasesRadiosurgery systemTrigeminal neuralgiaPrescription dosesGamma Knife systemMetastatic casesArteriovenous malformationsPituitary adenomasConformality indexLarge cohortDosimetric comparisonStereotactic radiosurgery systemGK IconPatientsCohortTreatment timeDosimetric results
2022
Frequency of errors in the transfer of treatment parameters from the treatment planning system to the oncology information system in a multi‐vendor environment
Donahue W, Draeger E, Han D, Chen Z. Frequency of errors in the transfer of treatment parameters from the treatment planning system to the oncology information system in a multi‐vendor environment. Journal Of Applied Clinical Medical Physics 2022, 24: e13868. PMID: 36527239, PMCID: PMC10113690, DOI: 10.1002/acm2.13868.Peer-Reviewed Original ResearchMeSH KeywordsHumansNeoplasmsRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, Intensity-ModulatedSoftwareConceptsInformation systemsTransfer of dataPlanning systemSoftware systemsOncology information systemMultiple vendorsData transferField labelsData inputTimer settingsNumber of errorsTechnological advancementsErrorSystemVendorsAdvancementTreatment planning systemFrequency of errorsMOSAIQCommon errorsLabelsInformationA small footprint couch‐top support device for image‐guided radiotherapy of heavy patients
Chen H, Morley K, Rodriguez R, Draeger E, Hassan M, Chen Z. A small footprint couch‐top support device for image‐guided radiotherapy of heavy patients. Journal Of Applied Clinical Medical Physics 2022, 23: e13788. PMID: 36267043, PMCID: PMC9797158, DOI: 10.1002/acm2.13788.Peer-Reviewed Original ResearchMeSH KeywordsHumansPhantoms, ImagingRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, Image-GuidedRadiotherapy, Intensity-ModulatedSkin dose distributions between Stanford and rotational techniques in total skin electron therapy (TSET)
Ding G, Chen Z, Zhong W, Zhu T. Skin dose distributions between Stanford and rotational techniques in total skin electron therapy (TSET). Medical Physics 2022, 49: 6646-6653. PMID: 35972019, DOI: 10.1002/mp.15907.Peer-Reviewed Original ResearchMeSH KeywordsElectronsHumansMonte Carlo MethodRadiotherapy DosageRadiotherapy Planning, Computer-AssistedSkinSkin NeoplasmsConceptsTotal skin electron therapyDose coverageStanford techniqueAdvanced-stage cutaneous T-cell lymphomaCutaneous T-cell lymphomaSkin dose distributionRotational techniqueT-cell lymphomaPatient's postureSimilar dose coverageDose distributionExtended treatment distancesElectron therapyMean doseEffective treatmentSame patientSmall dose differencesClinical settingPatient treatmentSkin dosesRealistic clinical settingsSkin doseDoseDifferent posturesDistribution of doseDosimetric study of Varian Universal Multi-Channel Cylinder System for High-Dose-Rate 192Ir Brachytherapy
Tien CJ, Damast S, Chen ZJ. Dosimetric study of Varian Universal Multi-Channel Cylinder System for High-Dose-Rate 192Ir Brachytherapy. Brachytherapy 2022, 21: 244-254. PMID: 34996715, DOI: 10.1016/j.brachy.2021.11.001.Peer-Reviewed Original ResearchAlgorithmsBrachytherapyFemaleHumansRadiometryRadiotherapy DosageRadiotherapy Planning, Computer-Assisted
2020
Clinically-implementable template plans for multidwell treatments using Leipzig-style applicators in 192Ir surface brachytherapy
Draeger E, Pinkham DW, Chen ZJ, Tien CJ. Clinically-implementable template plans for multidwell treatments using Leipzig-style applicators in 192Ir surface brachytherapy. Brachytherapy 2020, 20: 401-409. PMID: 33288488, DOI: 10.1016/j.brachy.2020.09.019.Peer-Reviewed Original ResearchAlgorithmsBrachytherapyHumansPhantoms, ImagingRadiotherapy DosageRadiotherapy Planning, Computer-AssistedAssociating dose–volume characteristics with theoretical radiobiological metrics for rapid Gamma Knife stereotactic radiosurgery plan evaluation
Tien CJ, Bond JE, Chen Z. Associating dose–volume characteristics with theoretical radiobiological metrics for rapid Gamma Knife stereotactic radiosurgery plan evaluation. Journal Of Applied Clinical Medical Physics 2020, 21: 132-140. PMID: 32910543, PMCID: PMC7592963, DOI: 10.1002/acm2.13018.Peer-Reviewed Original ResearchBenchmarkingLinear ModelsRadiobiologyRadiosurgeryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedA general-purpose Monte Carlo particle transport code based on inverse transform sampling for radiotherapy dose calculation
Liang Y, Muhammad W, Hart GR, Nartowt BJ, Chen ZJ, Yu JB, Roberts KB, Duncan JS, Deng J. A general-purpose Monte Carlo particle transport code based on inverse transform sampling for radiotherapy dose calculation. Scientific Reports 2020, 10: 9808. PMID: 32555530, PMCID: PMC7300009, DOI: 10.1038/s41598-020-66844-7.Peer-Reviewed Original ResearchMeSH KeywordsCobalt RadioisotopesFeasibility StudiesMonte Carlo MethodParticle AcceleratorsPhantoms, ImagingRadiation DosageRadiotherapy DosageRadiotherapy Planning, Computer-AssistedWaterConceptsPhoton transportBoundary crossing algorithmMonte Carlo particle transport codeMonte Carlo methodTransport simulationsAcceptance-rejection samplingRadiotherapy dose calculationsPhoto-electric effectParticle transport codeEGSnrc simulationsCarlo methodBremsstrahlung eventsInelastic scatteringPair productionRayleigh scatteringThread divergenceMC simulationsTransport codeMC codeHistory schemeParticle transportCrossing algorithmInverseElectron transportSimulation accuracyFeasibility of using multiple-dwell positions in 192Ir Leipzig-style brachytherapy surface applicators to expand target coverage and clinical application
Tien CJ, Pinkham DW, Chen ZJ. Feasibility of using multiple-dwell positions in 192Ir Leipzig-style brachytherapy surface applicators to expand target coverage and clinical application. Brachytherapy 2020, 19: 532-543. PMID: 32327342, DOI: 10.1016/j.brachy.2020.03.002.Peer-Reviewed Original ResearchAlgorithmsBrachytherapyFeasibility StudiesFilm DosimetryHumansIridium RadioisotopesPhantoms, ImagingRadiotherapy DosageRadiotherapy Planning, Computer-Assisted
2019
Deployment and performance of model-based dose calculation algorithm in 192Ir shielded cylinder brachytherapy
Tien CJ, Chen ZJ. Deployment and performance of model-based dose calculation algorithm in 192Ir shielded cylinder brachytherapy. Brachytherapy 2019, 18: 883-889. PMID: 31444132, DOI: 10.1016/j.brachy.2019.07.006.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBrachytherapyDrug ImplantsEquipment DesignHumansIridium RadioisotopesMonte Carlo MethodNeoplasmsPhantoms, ImagingRadiotherapy DosageRadiotherapy Planning, Computer-Assisted
2017
On the use of bolus for pacemaker dose measurement and reduction in radiation therapy
Yan H, Guo F, Zhu D, Stryker S, Trumpore S, Roberts K, Higgins S, Nath R, Chen Z, Liu W. On the use of bolus for pacemaker dose measurement and reduction in radiation therapy. Journal Of Applied Clinical Medical Physics 2017, 19: 125-131. PMID: 29152840, PMCID: PMC5768029, DOI: 10.1002/acm2.12229.Peer-Reviewed Original ResearchIncorporating patient-specific CT-based ophthalmic anatomy in modeling iodine-125 eye plaque brachytherapy dose distributions
Tien CJ, Astrahan MA, Kim JM, Materin M, Chen Z, Nath R, Liu W. Incorporating patient-specific CT-based ophthalmic anatomy in modeling iodine-125 eye plaque brachytherapy dose distributions. Brachytherapy 2017, 16: 1057-1064. PMID: 28778599, DOI: 10.1016/j.brachy.2017.06.014.Peer-Reviewed Original ResearchMeSH KeywordsBrachytherapyEye NeoplasmsHumansIodine RadioisotopesOphthalmoscopyRadiotherapy DosageRadiotherapy Planning, Computer-AssistedTomography, X-Ray ComputedConceptsEye modelDisc distanceDose differenceTumor apexPrescription doseOcular parametersPlaque SimulatorOcular structuresSubstantial dose differencesTarget volumePlaque positionDosimetric parametersPatientsClinical planningDosimetric impactSignificant differencesBrachytherapy planningSeed strengthPlaquesBrachytherapy dose distributionsDose distributionPatient-specific modelsDifferencesTumorsRetinaComparison of 2D and 3D modeled tumor motion estimation/prediction for dynamic tumor tracking during arc radiotherapy
Liu W, Ma X, Yan H, Chen Z, Nath R, Li H. Comparison of 2D and 3D modeled tumor motion estimation/prediction for dynamic tumor tracking during arc radiotherapy. Physics In Medicine And Biology 2017, 62: n168-n179. PMID: 28263949, DOI: 10.1088/1361-6560/aa64c8.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal NeoplasmsAlgorithmsHumansImaging, Three-DimensionalMovementRadiometryRadiotherapy Planning, Computer-AssistedThoracic NeoplasmsConceptsSystem latencyMotion trackingReal-time imaging techniqueMotion compensation frameworkTracking accuracyBeam directionRespiratory motion dataEstimation/predictionPotential dosimetric advantagesAdditional kVTumor trackingDepth directionTracking latencyView planeDosimetric advantagesMotion dataTracking errorDynamic tumor trackingImaging techniquesBlockage problemDetection errorBlockage issueUnresolved motionTrackingCompensation framework
2016
State of dose prescription and compliance to international standard (ICRU-83) in intensity modulated radiation therapy among academic institutions
Das IJ, Andersen A, Chen Z, Dimofte A, Glatstein E, Hoisak J, Huang L, Langer MP, Lee C, Pacella M, Popple RA, Rice R, Smilowitz J, Sponseller P, Zhu T. State of dose prescription and compliance to international standard (ICRU-83) in intensity modulated radiation therapy among academic institutions. Practical Radiation Oncology 2016, 7: e145-e155. PMID: 28274405, DOI: 10.1016/j.prro.2016.11.003.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceGuideline AdherenceHumansMalePractice Guidelines as TopicRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, Intensity-ModulatedRetrospective StudiesTreatment OutcomeConceptsDose-volume histogramsDose prescriptionRadiation therapyHomogeneity indexICRU-83Stereotactic body radiation therapyBody radiation therapyTreatment sitesInstitutional review board clearanceLung sitesClinical trialsPelvic sitesPrescribed doseInternational guidelinesTumor siteArc therapyPatient treatmentTarget volumeTherapyPatientsDoseLevels of dosePrescriptionP-valueDose delivery
2011
Testicular Doses in Image-Guided Radiotherapy of Prostate Cancer
Deng J, Chen Z, Yu JB, Roberts KB, Peschel RE, Nath R. Testicular Doses in Image-Guided Radiotherapy of Prostate Cancer. International Journal Of Radiation Oncology • Biology • Physics 2011, 82: e39-e47. PMID: 21489702, DOI: 10.1016/j.ijrobp.2011.01.071.Peer-Reviewed Original ResearchConceptsImage-guided radiotherapyTesticular dosesFull-fan modeProstate cancerFemoral headLess doseCBCT scansHalf-fan modeProstate cancer patientsKilovoltage cone-beamCancer patientsIntensity-modulated radiotherapy (IMRT) treatmentKilovoltage CBCTSuperior-inferior directionCone beamDosesCBCT fieldProstate patientsRectumDoseProstateMore doseRadiotherapy treatmentPatientsRadiotherapy
2008
Clinical implementation of enhanced dynamic wedges into the Pinnacle treatment planning system: Monte Carlo validation and patient-specific QA
Ahmad M, Deng J, Lund MW, Chen Z, Kimmett J, Moran MS, Nath R. Clinical implementation of enhanced dynamic wedges into the Pinnacle treatment planning system: Monte Carlo validation and patient-specific QA. Physics In Medicine And Biology 2008, 54: 447-465. PMID: 19098353, DOI: 10.1088/0031-9155/54/2/018.Peer-Reviewed Original ResearchMeSH KeywordsBiophysical PhenomenaHumansModels, TheoreticalMonte Carlo MethodParticle AcceleratorsPhantoms, ImagingQuality Assurance, Health CareRadiotherapy Planning, Computer-AssistedRadiotherapy, ConformalRadiotherapy, High-EnergyScattering, RadiationEvaluation of an electron Monte Carlo dose calculation algorithm for electron beams
Hu YA, Song H, Chen Z, Zhou S, Yin F. Evaluation of an electron Monte Carlo dose calculation algorithm for electron beams. Journal Of Applied Clinical Medical Physics 2008, 9: 1-15. PMID: 18716583, PMCID: PMC5722292, DOI: 10.1120/jacmp.v9i3.2720.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsElectronsMonte Carlo MethodParticle AcceleratorsRadiotherapy Planning, Computer-AssistedConceptsElectron Monte Carlo dose calculation algorithmMonte Carlo dose calculation algorithmGrid sizeDose calculation algorithmCalculation grid sizeCalculation algorithmEMC algorithmElectron beamMonte Carlo simulationsElectron beam directionMeasurement dataCutout factorsCalculation iterationsCarlo simulationsDose distributionMeV electron beamLinac headBeam characteristicsBeam dataBeam directionMinimal measurementsMaximum discrepancyAlgorithmDose calculationsBeam
2006
Evaluation of the EDR-2 film for relative dosimetry of high-energy photon and electron beams
Ahmad M, Chen Z, Song H, Deng J, Nath R. Evaluation of the EDR-2 film for relative dosimetry of high-energy photon and electron beams. Radiation Protection Dosimetry 2006, 120: 159-162. PMID: 16644932, DOI: 10.1093/rpd/ncj006.Peer-Reviewed Original ResearchMeSH KeywordsDose-Response Relationship, RadiationElectronsEquipment DesignEquipment Failure AnalysisFilm DosimetryPhotonsRadiation DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, High-EnergyReproducibility of ResultsSensitivity and SpecificityConceptsEDR-2 filmsElectron beamRelative dosimetryHigh-energy photonsClinical radiation dosimetryDose profilesPhotonsRadiation dosimetryBeamDose distributionRadiographic filmsSensitometric studyFilmsDosimetryTreatment planning techniquesElectronsDiodesSymmetryKVFlatnessPlanning techniquesDistributionPotential impact of prostate edema on the dosimetry of permanent seed implants using the new (model CS‐1) seeds
Chen Z, Deng J, Roberts K, Nath R. Potential impact of prostate edema on the dosimetry of permanent seed implants using the new (model CS‐1) seeds. Medical Physics 2006, 33: 968-975. PMID: 16696473, DOI: 10.1118/1.2179170.Peer-Reviewed Original ResearchMeSH KeywordsBrachytherapyCesium RadioisotopesEdemaHumansMaleProstatic NeoplasmsProsthesis ImplantationRadiometryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedReproducibility of ResultsSensitivity and Specificity