2023
Radiobiological evaluation of the stepping-source effect in single-fraction monotherapy high-dose-rate prostate brachytherapy
Tien C, Chen Z. Radiobiological evaluation of the stepping-source effect in single-fraction monotherapy high-dose-rate prostate brachytherapy. Brachytherapy 2023, 22: 593-606. PMID: 37263898, DOI: 10.1016/j.brachy.2023.03.003.Peer-Reviewed Original Research
2022
Dosimetric study of Varian Universal Multi-Channel Cylinder System for High-Dose-Rate 192Ir Brachytherapy
Tien CJ, Damast S, Chen ZJ. Dosimetric study of Varian Universal Multi-Channel Cylinder System for High-Dose-Rate 192Ir Brachytherapy. Brachytherapy 2022, 21: 244-254. PMID: 34996715, DOI: 10.1016/j.brachy.2021.11.001.Peer-Reviewed Original Research
2020
Clinically-implementable template plans for multidwell treatments using Leipzig-style applicators in 192Ir surface brachytherapy
Draeger E, Pinkham DW, Chen ZJ, Tien CJ. Clinically-implementable template plans for multidwell treatments using Leipzig-style applicators in 192Ir surface brachytherapy. Brachytherapy 2020, 20: 401-409. PMID: 33288488, DOI: 10.1016/j.brachy.2020.09.019.Peer-Reviewed Original ResearchA prototype open-ended multichannel intracavitary-interstitial hybrid applicator for gynecological high-dose-rate brachytherapy
Tien CJ, Chen Z. A prototype open-ended multichannel intracavitary-interstitial hybrid applicator for gynecological high-dose-rate brachytherapy. Radiological Physics And Technology 2020, 13: 187-194. PMID: 32424632, DOI: 10.1007/s12194-020-00567-2.Peer-Reviewed Original ResearchConceptsPrescription doseRate brachytherapyHybrid applicatorPrior patientsRisk doseMinimum doseOAR D2ccMultichannel applicatorCentral tandemDoseTarget coverageInterstitial needlesPatientsApplicator bodyBrachytherapyDistal endOpen distal endsPeripheral needlesPeripheral channelsSilico studiesNeedleBowelBladderD2ccRectumFeasibility of using multiple-dwell positions in 192Ir Leipzig-style brachytherapy surface applicators to expand target coverage and clinical application
Tien CJ, Pinkham DW, Chen ZJ. Feasibility of using multiple-dwell positions in 192Ir Leipzig-style brachytherapy surface applicators to expand target coverage and clinical application. Brachytherapy 2020, 19: 532-543. PMID: 32327342, DOI: 10.1016/j.brachy.2020.03.002.Peer-Reviewed Original Research
2019
Deployment and performance of model-based dose calculation algorithm in 192Ir shielded cylinder brachytherapy
Tien CJ, Chen ZJ. Deployment and performance of model-based dose calculation algorithm in 192Ir shielded cylinder brachytherapy. Brachytherapy 2019, 18: 883-889. PMID: 31444132, DOI: 10.1016/j.brachy.2019.07.006.Peer-Reviewed Original ResearchHigh-dose-rate brachytherapy as monotherapy for prostate cancer: The impact of cellular repair and source decay
Tien CJ, Carlson DJ, Nath R, Chen ZJ. High-dose-rate brachytherapy as monotherapy for prostate cancer: The impact of cellular repair and source decay. Brachytherapy 2019, 18: 701-710. PMID: 31109870, DOI: 10.1016/j.brachy.2019.04.005.Peer-Reviewed Original Research
2018
Monte Carlo dosimetry modeling of focused kV x‐ray radiotherapy of eye diseases with potential nanoparticle dose enhancement
Yan H, Ma X, Sun W, Mendez S, Stryker S, Starr‐Baier S, Delliturri G, Zhu D, Nath R, Chen Z, Roberts K, MacDonald CA, Liu W. Monte Carlo dosimetry modeling of focused kV x‐ray radiotherapy of eye diseases with potential nanoparticle dose enhancement. Medical Physics 2018, 45: 4720-4733. PMID: 30133705, DOI: 10.1002/mp.13144.Peer-Reviewed Original ResearchConceptsX-ray beamMC simulation programEye plaque treatmentCentral axis depth doseMC simulationsDose distributionBeam focusingEye Physics plaquesPhantom irradiationDose enhancementEnergy spectrumDepth doseLens modelingDosimetry modelingPhotoelectric absorptionKV rangeKV X-ray beamsBeamEBT3 filmSimulation programEnergy regimeModelingX-ray techniquesHalf maximumMore flexibilityExtended duration of dilator use beyond 1 year may reduce vaginal stenosis after intravaginal high-dose-rate brachytherapy
Stahl JM, Qian JM, Tien CJ, Carlson DJ, Chen Z, Ratner ES, Park HS, Damast S. Extended duration of dilator use beyond 1 year may reduce vaginal stenosis after intravaginal high-dose-rate brachytherapy. Supportive Care In Cancer 2018, 27: 1425-1433. PMID: 30187220, DOI: 10.1007/s00520-018-4441-5.Peer-Reviewed Original ResearchConceptsVaginal stenosisEndometrial carcinomaMultivariable Cox proportional hazardsMultivariable Cox regression analysisVD useAcademic tertiary referral centerTertiary referral centerCox regression analysisLog-rank testCox proportional hazardsDevelopment of gradeDilator usePelvic radiotherapyReferral centerNoncompliant patientsPrimary outcomeAdjuvant brachytherapyEC patientsConclusionsThe riskRate brachytherapyProportional hazardsOptimal durationPatientsBrachytherapyStudy period
2017
Incorporating patient-specific CT-based ophthalmic anatomy in modeling iodine-125 eye plaque brachytherapy dose distributions
Tien CJ, Astrahan MA, Kim JM, Materin M, Chen Z, Nath R, Liu W. Incorporating patient-specific CT-based ophthalmic anatomy in modeling iodine-125 eye plaque brachytherapy dose distributions. Brachytherapy 2017, 16: 1057-1064. PMID: 28778599, DOI: 10.1016/j.brachy.2017.06.014.Peer-Reviewed Original ResearchConceptsEye modelDisc distanceDose differenceTumor apexPrescription doseOcular parametersPlaque SimulatorOcular structuresSubstantial dose differencesTarget volumePlaque positionDosimetric parametersPatientsClinical planningDosimetric impactSignificant differencesBrachytherapy planningSeed strengthPlaquesBrachytherapy dose distributionsDose distributionPatient-specific modelsDifferencesTumorsRetina
2011
Experimental characterization of the dosimetric properties of a newly designed I-Seed model AgX100 125I interstitial brachytherapy source
Chen Z, Bongiorni P, Nath R. Experimental characterization of the dosimetric properties of a newly designed I-Seed model AgX100 125I interstitial brachytherapy source. Brachytherapy 2011, 11: 476-482. PMID: 22104352, PMCID: PMC3330133, DOI: 10.1016/j.brachy.2011.08.009.Peer-Reviewed Original ResearchThe impact of prostate edema on cell survival and tumor control after permanent interstitial brachytherapy for early stage prostate cancers
Chen Z, Roberts K, Decker R, Pathare P, Rockwell S, Nath R. The impact of prostate edema on cell survival and tumor control after permanent interstitial brachytherapy for early stage prostate cancers. Physics In Medicine And Biology 2011, 56: 4895-4912. PMID: 21772076, PMCID: PMC3154133, DOI: 10.1088/0031-9155/56/15/016.Peer-Reviewed Original ResearchConceptsPermanent interstitial brachytherapyProstate edemaProstate cancerEffects of edemaTumor control probabilityImpact of edemaInterstitial brachytherapyCell survivalEarly-stage prostate cancerControl probabilityStage prostate cancerCurrent clinical practiceProstate cancer cellsTumor cell proliferationInterstitial brachytherapy treatmentSublethal damage repairDose variationTumor cell survivalTumor characteristicsTumor controlClinical impactEdemaEdema evolutionClinical practiceProstate gland
2010
A systematic evaluation of the dose-rate constant determined by photon spectrometry for 21 different models of low-energy photon-emitting brachytherapy sources
Chen Z, Nath R. A systematic evaluation of the dose-rate constant determined by photon spectrometry for 21 different models of low-energy photon-emitting brachytherapy sources. Physics In Medicine And Biology 2010, 55: 6089-6104. PMID: 20871136, PMCID: PMC3265933, DOI: 10.1088/0031-9155/55/20/004.Peer-Reviewed Original ResearchImpact of source‐production revision on the dose‐rate constant of interstitial brachytherapy sources
Chen Z, Bongiorni P, Nath R. Impact of source‐production revision on the dose‐rate constant of interstitial brachytherapy sources. Medical Physics 2010, 37: 3607-3610. PMID: 20831068, PMCID: PMC2902542, DOI: 10.1118/1.3453766.Peer-Reviewed Original ResearchResponse to “Comment on ‘AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137’” [Med. Phys. 36, 5310–5322 (2009)]
Nath R, Bice WS, Butler WM, Chen Z, Meigooni AS, Narayana V, Rivard MJ, Yu Y. Response to “Comment on ‘AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137’” [Med. Phys. 36, 5310–5322 (2009)]. Medical Physics 2010, 37: 1933-1933. PMID: 20443515, DOI: 10.1118/1.3358143.Peer-Reviewed Original ResearchA photon spectrometric dose‐rate constant determination for the Advantage™ Pd‐103 brachytherapy source
Chen ZJ, Bongiorni P, Nath R. A photon spectrometric dose‐rate constant determination for the Advantage™ Pd‐103 brachytherapy source. Medical Physics 2010, 37: 672-674. PMID: 20229876, PMCID: PMC2821420, DOI: 10.1118/1.3298011.Peer-Reviewed Original Research
2009
AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137
Nath R, Bice WS, Butler WM, Chen Z, Meigooni AS, Narayana V, Rivard MJ, Yu Y. AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137. Medical Physics 2009, 36: 5310-5322. PMID: 19994539, PMCID: PMC2776817, DOI: 10.1118/1.3246613.Peer-Reviewed Original ResearchConceptsBiological equivalent doseTumor volumeDose prescriptionStandard of careProstate cancer patientsPermanent interstitial brachytherapyAcute single dosesEffects of edemaCancer patientsSurgical traumaIntraoperative implantationSingle dosesClinical trialsProstate cancerRadiobiological modelsCurrent recommendationsInterstitial brachytherapyMore specific guidelinesRoutine patient treatmentsDifferent dose distributionsTreatment planPatient treatmentTarget volumeMost implantsDose distributionTime dependence of energy spectra of brachytherapy sources and its impact on the half and the tenth value layers
Yue NJ, Chen Z, Hearn RA, Rodgers JJ, Nath R. Time dependence of energy spectra of brachytherapy sources and its impact on the half and the tenth value layers. Medical Physics 2009, 36: 5175-5182. PMID: 19994527, DOI: 10.1118/1.3246843.Peer-Reviewed Original Research
2008
Ice as a water-equivalent solid medium for brachytherapy dosimetric measurements
Song H, Chen Z, Yue N, Wu Q, Yin FF. Ice as a water-equivalent solid medium for brachytherapy dosimetric measurements. Radiation And Environmental Biophysics 2008, 48: 145-151. PMID: 19066926, DOI: 10.1007/s00411-008-0205-9.Peer-Reviewed Original ResearchConceptsSolid phantomWater conversion factorNon-negligible uncertaintiesMono-energetic photonsPrecise positioningLow-energy photon-emitting brachytherapy sourcesChemical compositionBrachytherapy sourcesPositioning advantageDosimetric measurementsExperimental determinationNecessary precisionDosimetric characteristicsPhantomIceBrachytherapy dosimetryPositioningConversion factorPhotonsUncertaintyKeVPhoton energy spectrum emitted by a novel polymer‐encapsulated source and its effect on the dose rate constant
Khan S, Chen ZJ, Nath R. Photon energy spectrum emitted by a novel polymer‐encapsulated source and its effect on the dose rate constant. Medical Physics 2008, 35: 1403-1406. PMID: 18491535, PMCID: PMC2673625, DOI: 10.1118/1.2870231.Peer-Reviewed Original Research