Yale Cancer Center

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Racing to solve rare diseases
Institutional support encourages researchers and clinicians to diagnose and treat rare diseases.
22 May 2023
News
Novel Gene Identified as Genetic Cause of Portal Hypertension
Novel Gene Identified as Genetic Cause of Portal Hypertension
6 May 2021
News
The New Machinery of Medicine: How Gene Sequencing and High-Performance Computing Are Revolutionizing Care
Gene sequencing and high-performance computing are poised to improve patient care through precision medicine.
1 Jul 2019
News
Stem cell mutations linked to hydrocephalus
Hydrocephalus is characterized by a dangerous buildup of pressure on the brain caused by excessive amounts of fluid. Researchers have long believed that the condition, which affects one of every thousand babies born, was caused by excessive production of cerebral spinal fluid or an inability of the brain to properly absorb it.
11 Jul 2018
News
Remembering Carolyn Slayman
When Carolyn Walch Slayman, PhD, was named chair of the Department of Human Genetics (now Genetics) in 1984, she was the first woman to head a department at the School of Medicine, and the second at Yale University. That she didn’t expect the news to make a big splash—it was a front-page story..
14 May 2018
News
Putting the precise in precision medicine
About eight years ago, a doctor in Turkey examined a 5-month-old boy for “failure to thrive and dehydration. ” Paradoxically, his diapers were wet, so the medical team was inclined to suspect Bartter syndrome, a congenital kidney defect which is manageable if caught early.
25 Oct 2017
News
Deputy dean deeply mourned at the School of Medicine
In the freezer of Carolyn Walch Slayman’s lab, her chief lab technician Ken Allen stored vials of cultures from her graduate school days studying biochemical genetics at Rockefeller University. They were set aside by her mentor, Nobel laureate E.
21 Feb 2017
News
In memoriam: Carolyn Walch Slayman, Ph.D.
Carolyn Walch Slayman, Ph.D., deputy dean for academic and scientific affairs at the School of Medicine, Sterling Professor of Genetics, and professor of cellular and molecular physiology, died on December 27 at Yale New Haven Hospital. She was 79, and had been undergoing treatment for recurrent breast cancer. Slayman was a faculty member and leader at the medical school for almost 50 years. While she was steadfastly humble about her accomplishments, her career was characterized by a series of
31 Jan 2017
News
Subtype of triple negative breast cancer responds better to chemotherapy
Researchers at Yale Cancer Center have identified a new subtype of triple negative breast cancer that shows significantly improved response to chemotherapy. Patients with the newly defined subtype — BRCA-deficient triple negative breast cancer — had significantly higher survival rates with chemotherapy.
12 Dec 2016
News
Researchers find genes behind aggressive ovarian and endometrial cancers
In a major breakthrough for ovarian and uterine cancers, Yale researchers have defined the genetic landscape of rare, highly aggressive tumors called carcinosarcomas (CSs), pointing the way to possible new treatments. The findings are published in the Oct. 10 online early edition of Proceedings of the National Academy of Sciences.
10 Oct 2016
News
Researchers find genes behind aggressive ovarian and endometrial cancers
In a major breakthrough for ovarian and uterine cancers, Yale researchers have defined the genetic landscape of rare, highly aggressive tumors called carcinosarcomas (CSs), pointing the way to possible new treatments.
10 Oct 2016
News
FAT1 mutations cause a glomerulotubular nephropathy.
Steroid-resistant nephrotic syndrome (SRNS) causes 15% of chronic kidney disease (CKD).
Source: Nature
23 Feb 2016
News
Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma.
Parts of clear cell renal cell carcinomas (ccRCCs) sometimes have histologic features characteristic of a sarcoma.
Source: Proceedings of the National Academy of Sciences of the United States of America PNAS, Proceedings of the National Academy of Sciences
22 Feb 2016
News
Early and multiple origins of metastatic lineages within primary tumors.
The knowledge that cancer is an evolutionary process is old, but only recently can sequencing technology provide data for clinically relevant evolutionary analyses of cancer.
Source: Proceedings of the National Academy of Sciences of the United States of America
22 Feb 2016
News
Service drives M.D./Ph.D. student
The idea of “seva,” a word that in several Indian languages means “selfless service,” underlies everything that Durga Thakral, an M. D.
12 Feb 2016
News
Yale study examines evolution of cancer
A novel Yale study answers age-old questions about how cancers spread by applying tools from evolutionary biology. The new insights will help scientists better understand the genetic origins of tumor metastases, and lead to more effective targets for treatment, said the researchers. The study, led by associate professor of public health (biostatistics) Jeffrey Townsend, was published on Feb. 8 by the Proceedings of the National Academy of Sciences.
7 Feb 2016
News
Deadly and distinctive: Cancer caused by gene deletions
A deadly form of T cell lymphoma is caused by an unusually large number gene deletions, making it distinct among cancers, a new Yale School of Medicine study shows.
20 Jul 2015
News
When a gene goes awry: one family’s story
It took medical and genetic sleuthing to unravel the mystery of an infant’s death and a father’s fevers. In the end, doctors treated a disease that hadn’t been described before.
11 Jun 2015
News
Building a biobank … a million veterans at a time
The exhortation to “enlist” wasn’t as dramatic as that of the famous “I Want You” poster featuring a red-, white-, and blue-clad Uncle Sam, but William Koob, 71, a seaman’s apprentice in the early 1960s, found the call almost as compelling. Koob, a bank auditor, was semi-retired and working at..
8 May 2015
News
When a gene goes awry
When Mustafa K. Khokha, M.
8 May 2015