Yale Cancer Center

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Fat Cells Play a Protective Role in Fibrosis Development
People with skin fibrosis experience a painful thickening of the skin, for which there is no treatment. Findings from a Yale study may point the way.
Source: Yale News
29 Jan 2025
News
Paid Child Rearing Leave Extended
Yale School of Medicine has extended its paid child rearing leave for eligible faculty from eight weeks to 12 weeks thanks to support from Valerie Horsley, PhD, and Megan King, PhD.
8 Feb 2022
News
Mechanotransduction regulates epidermal differentiation
This collaboration between the Horsley lab (MCDB) and Lusk/King lab (Cell Biology and MCDB) led to the discovery that a molecular bridge spanning the nuclear envelope (the LINC complex) is under mechanical load in response to the extracellular environment as engaged and sensed by a class of cell surface receptors called integrins. This force transduction mechanism plays an important role in regulating epidermal differentiation in mice, suggesting that LINC complexes propagate mechanical signals to the nucleus, where they impact on the accessibility and expression of genes important for epidermal differentiation.
Source: eLife
29 Mar 2021
News
Cells beneath the skin explain differences in healing
Differences in the cells that give skin its resilience and strength during wound repair may explain why individuals heal differently, according to a new Yale study published Nov. 23 in the journal Science.
21 Nov 2018
News
Dr. Valerie Horsley Receives the 2012 Rosalind Franklin Young Investigator Award from the Genetics Society of America
This career development research award is intended to inspire and support new generations of women in the field of genetics. The Rosalind Franklin Young Investigator Award is funded by The Peter and Patricia Gruber Foundation, and is administered by a joint committee appointed by the Genetics Society of America and the American Society of Human Genetics.
28 Aug 2012
News
Stem cell researcher receives top Presidential Award
Valerie Horsley, the Maxine F. Singer Assistant Professor of Molecular, Cellular, and Developmental Biology at Yale, has been awarded the Presidential Early Career Award for Scientists and Engineers for her work on the generation of skin cells.
Source: Yale News
27 Jul 2012
News
Valerie Horsley named to Maxine F. Singer endowed post
Valerie Horsley, recently designated as the Maxine F. Singer ’57 Ph.D. Assistant Professor of Molecular, Cellular, and Developmental Biology, studies the cellular and molecular mechanisms that control stem cell activity and function within epithelia — the tissues that line our internal organs and outer surfaces.
Source: Yale News
15 Nov 2011
News
A stem cell research project takes an unexpected turn
Valerie Horsley and her fellow researchers at Yale University were looking at the role fat cells play in the skin, part of a broader examination into how tissues maintain themselves, when their work took them in a totally unexpected direction: Now they're looking at a potential treatment for baldness.
Source: The CT Mirror
2 Sep 2011
News
Yale Scientists Find Stem Cells That Tell Hair It's Time to Grow
Yale researchers have discovered the source of signals that trigger hair growth, an insight that may lead to new treatments for baldness.
1 Sep 2011
News
Fatty skin cell clue to baldness
The Yale University team says it may be possible to use the findings to one day restart hair growth to reverse balding.
Source: BBC News
1 Sep 2011
News
Dr. Valerie Horsley
Dr. Horsley and colleagues discover new cell: cell crosstalk in the skin stem cell niche.
10 Feb 2011