Testing the Combination of New Anti-cancer Drug Peposertib with Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies
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Health Professionals
What is the purpose of this trial?
This phase I/II trial studies the best dose and side effects of peposertib and to see how well it works with avelumab and hypofractionated radiation therapy in treating patients with solid tumors and hepatobiliary malignancies that have spread to other places in the body (advanced/metastatic). Peposertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as avelumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects. Giving peposertib in combination with avelumab and hypofractionated radiation therapy may work better than other standard chemotherapy, hormonal, targeted, or immunotherapy medicines available in treating patients with solid tumors and hepatobiliary malignancies.
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Principal Investigator
Sub-Investigators
- Agatha Hecht
- Alison Johnson
- Allison Campbell, MD, PhD
- Anca Bulgaru, MD
- Andrea Brennan
- Armand Russo, MD
- Ashita Talsania, MRCP, MBBS
- Benjamin Newton, MD
- Beverly Drucker, MD, PhD
- Clarice Grens
- D. Barry Boyd, MD, MS
- Daniel Hicks, MD
- Elan Gorshein, DO, JD, MPH
- Emily Kopas, APRN, OCN
- Genevieve Maquilan, MD
- Jacquelyne Gaddy, MD, MSc, MSCR
- James Laird, MD
- James Vredenburgh, MD
- Jane Kanowitz, MD
- Jason Haldas, MD
- Jeremy Kortmansky, MD
- Jill Lacy, MD
- Johanna LaSala, MD
- John Kunstman, MD, MHS, FACS
- Jose Morales-Marin
- Justin Persico, MD
- Karen Ann Hammond, DNP, APRN, ACNP (BC)
- Katelyn Scott
- Katherine Harvey, MD, MPH
- Kayla Martello
- Kert Sabbath, MD, FACP
- Kevin Du, MD, PhD, MSCI
- Kristen Hoxie
- Larisa Fleysher
- Laura Sabourin
- Laura Van Metre Baum, MD, MPH
- M. Sung Lee, MD
- Madeline Santiago
- Matthew Austin, MD
- Michael Burke
- Michael Cecchini, MD
- Michael Cohenuram, MD
- Michael Grant, MD
- Neal Fischbach, MD
- Osarugue Otasowie
- Pamela L. Kunz, MD
- Pawan Karanam, MD
- Raghav Sundar, MD, PhD
- Rebecca Vanasse-Passas, MD
- Renee Moye
- Robert Legare, MD
- Robert Matera, MD
- Sara Anastasio, RN
- Sarah Carlson
- Sarah Thomen, APRN
- Sharynn Hall, MD, PhD
- Stacey LaRosa
- Stephen Lattanzi, MD
- Su Hsien Lim, MD
- Susan Gueble, MD, PhD
- Teresa White
- Thejal Srikumar, MD, MPH
- Vanna Dest
- Victor Chang, MD
- Vidya Kesavan
- Virginia Syombathy
- Wajih Kidwai, MD, FACP
- Yifei Zhang, MD
- Zia Rahman, MD
- Last Updated11/14/2024
- Study HIC#2000038343